A5069334529- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Synthesis and biological activity
- Phytochemistry and Bioactive Compounds
- Pancreatic function and diabetes
- Nanoparticles: synthesis and applications
- Crystallization and Solubility Studies
- Phytochemical compounds biological activities
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Natural Antidiabetic Agents Studies
- Adenosine and Purinergic Signaling
- Endoplasmic Reticulum Stress and Disease
- Traditional and Medicinal Uses of Annonaceae
- Graphene and Nanomaterials Applications
- Pesticide and Herbicide Environmental Studies
- Soil Carbon and Nitrogen Dynamics
- Hepatitis C virus research
- Legume Nitrogen Fixing Symbiosis
- Immune cells in cancer
- Sesquiterpenes and Asteraceae Studies
Entrust
2024
Atatürk University
2024
University of Agriculture Faisalabad
2020-2023
University of Sargodha
2023
University of Karachi
2005-2022
International Center for Chemical and Biological Sciences
2005-2022
Sion College
2022
Government College Women University Sialkot
2022
University of Faisalabad
2020
Kohat University of Science and Technology
2011
Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent therapeutic option. However, breakthrough is complicated by selectivity issues since exists in four different isoforms. In work, we report that ellagic acid (EA) its derivatives, present numerous fruits vegetables, can inhibit PKL potently selectively. Several polyphenolic analogues EA were synthesized tested to identify the chemical...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunctionLassociated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
Background: Since its first discovery in the early 1980s, gram-negative bacterium Helicobacter pylori has attracted a lot of attention. Numerous gastrointestinal conditions, including peptic ulcers, chronic gastritis, and stomach malignancies, are linked to it. Therefore, purpose this study was determine prevalence H. infection among Quetta residents. Aims/Objectives: Estimating H pylori-associated gastritis District Quetta, Balochistan, as well identifying potential contributing demographic...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunctionLassociated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
A large portion of applied phosphorus fertilizer undergoes adsorption/fixation due to high pH and calcareous content soils becomes unavailable for plant uptake. Plants undergo many morphological physiological adaptations overcome the low availability. Many plants modify their root morphology biomass in environments by exploring a greater more soil volume. This study measured adaptation at different levels its effect on use efficiency. Results showed that efficiency, volume, number tips,...
Four new pterocarpans, atricarpan A (=(−)-1,2-dihydroxy-4-(hydroxymethyl)-3,9-dimethoxypterocarpan; 1), B (=(−)-2,3-ethylenedioxy)-1,4-dihydroxy-9-methoxypterocarpan; 2), C (=(−)-1,9-dimethoxypterocarpan-3-carboxylic acid; 3), and D (=(−)-2,9-dimethoxy-4-(5-oxohexyl)pterocarpan; 4) were isolated from the BuOH extract of whole plant Zygophyllum eurypterum. The structure elucidations those compounds based primarily on 1D- 2D-NMR analysis, including COSY, HMBC, HMQC correlations. Compounds 1–4...
Metabolic dysfunction-associated fatty liver disease (MAFLD) presents a significant global health challenge, characterized by the accumulation of fat and impacting considerable portion worldwide population. Despite its widespread occurrence, effective treatments for MAFLD are limited. The liver-specific isoform pyruvate kinase (PKL) has been identified as promising target developing therapies. Urolithin C, an allosteric inhibitor PKL, shown potential in preliminary studies. Expanding upon...
<title>Abstract</title> The pyruvate kinase L/R (PKLR) enzyme was associated with the progression of hepatocellular carcinoma (HCC) and metabolic dysfunction-associated fatty liver disease (MAFLD) identified as a potential drug target. Here, we first demonstrated anti-HCC effects recently developed six PKLR-modulating compounds, including SET135, SET156, SET158, SET159, SET171, SET172 JNK-IN-5A, repurposed compound for modulation PKLR based on systems biology. Compared multi-target...
Phytochemical investigations of the whole plant Stachys parviflora (Lamiaceae) resulted in isolation two new phenethyl alcohol glycosides. The structures compounds named parviflorosides A and B were established as 2-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl-(1 --> 2)-4-O-E-caffeoyl-beta-D-glucopyranoside (1) 2)-6-O-E-caffeoyl-beta-D-glucopyranoside (2), respectively. structure elucidation was based primarily on 1D 2D NMR analysis, including COSY, HMBC HMQC correlations.
Abstract Two new triterpenoidal saponins were isolated from the n ‐butanolic extract of Stachys parviflora (Lamiaceae). Their structures elucidated on basis spectral data as stachyssaponin A; 3β, 15α, 19α, 21β, 22α‐pentahydroxyolean‐12‐ene‐28‐oic acid 3‐ O ‐{α‐ L ‐rhamnopyranosyl‐(1 → 3)‐β‐ D ‐glucopyranoside}‐22‐ ‐arabinofuranosyl‐(1 ‐glucopyranoside} (1) and B; 2β, 21β‐tetrahydroxyolean‐12‐ene‐28‐oic 2‐ ‐[α‐ ‐arabinofuranoside]‐3, 21‐bis‐ ‐[β‐ ‐glucopyranoside] (2). Copyright © 2008 John...