A5077530774- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Alcohol Consumption and Health Effects
- Adenosine and Purinergic Signaling
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Free Radicals and Antioxidants
- Dendrimers and Hyperbranched Polymers
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- Synthesis and bioactivity of alkaloids
- Curcumin's Biomedical Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Carbon dioxide utilization in catalysis
- Synthesis of Indole Derivatives
- Phytochemistry and biological activity of medicinal plants
- Phagocytosis and Immune Regulation
- Bacteriophages and microbial interactions
- Electrospun Nanofibers in Biomedical Applications
- Protein Interaction Studies and Fluorescence Analysis
- Marine Sponges and Natural Products
International Center for Chemical and Biological Sciences
2012-2025
University of Karachi
2015-2025
Airlangga University
2025
Currently, chemotherapy is one of the most practiced approaches for treatment cancers. However, existing chemotherapeutic drugs have poor aqueous solubility, selectivity, higher systematic toxicity, and target accumulation. In this study, we designed synthesized a boronic acid/ester-based pH-responsive nano-valve that specifically targets microenvironment in cancer cells. The comprises phenylboronic acid-coated mesoporous silica nanoparticles (B-MSN) loaded with polyphenolic compound...
Benzophenonehydrazone Schiff bases 1-25 were synthesized and their in vitro antiglycation potential has been studied. Out of twenty-five compounds, thirteen showed varying degrees activity with IC50 values ranging between 25.7 - 305 μM, if compared the standard rutin (IC50 = 70.5 ± 0.50 μM). Compounds 21 (2,3- dihydroxybenzaldehyde N-(diphenylmethylene)hydrazine) 0.003 14 (diphenylmethanone N-[1-(2,4- dihydroxy-5-nitrophenyl)ethylidene]hydrazine) 36.6 0.004 6 (3,4-dihydroxybenzaldehyde N-...
2,4,6-Trichlorophenyl hydrazones 1-35 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 14 (IC50 = 27.2 ± 0.00 μM), 18 55.7 μM) showed an excellent activity against glycation of protein, better than the standard (rutin, IC50 70 0.50 μM). This study thus identified a novel series agents. A structure-activity relationship has been studied, all compounds characterized by spectroscopic techniques. Keywords: 2,4,6-trichlorophenyl hydrazones, Schiff bases,...
18β-Glycyrrhetinic acid (18β-GA) is known for several biological activities, and has been the focus of extensive research development therapeutic agents. In current study, 18β-GA-peptide conjugates 2-11 were evaluated their in vitro α-glucosidase inhibitory antiglycation activities. Structure-activity relationship (SAR) established molecular interactions active bioconjugates with enzyme's binding sites predicted through modeling approach. tripeptide moiety 2-11, peptide residue at position 1...
Tamarindus indica and Mitragyna inermis are widely used by herbalists to cure diabetes mellitus. The aim of this study is investigate the inhibitory potential aqueous various organic solvent fractions from both plants some isolated compounds against advanced glycation end-products (AGEs). For purpose, an in vitro BSA-fructose model was evaluate inhibition AGE formation. Furthermore, effects on mouse fibroblast (NIH-3T3) human hepatocyte (HepG2) survival were evaluated. leaf, stem, root...
Tinospora bakis (A.Rich.) Miers (Menispermaceae) has traditionally been used to alleviate headaches, rheumatism, mycetoma, and diabetes, among others. Despite its extensive use, the active components of plant have never investigated. In this work, a series furanoditerpenoids (1–18) five compounds from other classes (19–23) were isolated T. bakis. Notably, two new discovered named: tinobakisin (1) tinobakiside (10). Their molecular structures elucidated with NMR, MS, UV, IR, ECD spectra....
The present study is to isolate and characterize betulinic acid ricinine from T. conophorum seeds. Phytochemical investigation on hexane fraction of seeds led the isolation two compounds, Betulinic (1), Ricinine (2). were screened against HepG2 cells tested in vivo CCl4-induced experimental rats model. Results this showed that compounds had hepatoprotective cytotoxic activities. It was observed inhibited cell with percentage inhibition 54% compared standard doxorubicin (64%), while inactive...
Persistent hyperglycemia is linked to a range of chronic complications in diabetes, such as neuropathy, retinopathy, nephropathy, and atherosclerosis. The underlying cause the highly stable advanced glycation end products (AGEs) resulting from prolonged exposure high glucose level. Hence present study was undertaken on anti-glycation activity series synthetic analogues (Schiff bases) 4a-4o nitrovanillin synthesized by its coupling with different amino reagents. Nitrovanillin obtained...
A new sesquiterpene (Prosoterpene, 1) and eleven reported compounds (2-12) of several classes, such as flavonoids, alkaloids, phenolic acids, long-chain alcohols, were isolated from the BuOH extract Prosopis africana (Guill. & Perr.) Taub. Compounds 2-10 for first time this plant. Isomers 11 12 separated time. Extensive spectroscopic techniques literature comparisons used to characterise their structures. Furthermore, 3, 5-8, 10-12 performed anti-glycation cytotoxicity activities. Compound 3...
In Ethiopia, sesame is number one oilseed crop in terms of export value, but with low value addition practice. This research aimed to determine effect varieties and pre-oil extraction treatments on yield quality the oil. Results showed that varied from 47.1 57.5% iodine (IV) 106 113 g/100 g, free fatty acid (FFA) 0.47 1.36%, peroxide (PV) 0.66 7.04 meq O2/kg. Palmitic, oleic linoleic were major acids oil characterized by high unsaturated (80–85%) less saturated (15–20%) acids. All increased...
Abstract Diabetes mellitus is a metabolic disease, characterized by the elevated levels of blood glucose, known as hyperglycemia. It one serious health challenges, and rapidly becoming significant cause morbidity, mortality, worldwide. The persistent hyperglycemic state in diabetes leads to formation advanced glycation end products (AGEs), which identified key factor involved progression diabetes, diabetes‐associated late complications. keeping view medicinal properties indole, thiazole,...
Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The producing then cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay. photocytotoxicity HT-144 human line in presence of illumination (∼≥400 nm) was also evaluated. In standard MTT assay, ethanol extract S. (100 µg/ml) showed...
Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them currently being used, such as mefenamic and meclofenamates, possess analgesic, anti-inflammatory antipyretic activities. Some anthranilic acid-based scaffolds have also been reported for the management metabolic disorders.The aim current study was to investigate antiglycation potential 2-anilino benzoic against (N-phenylanthranilic acid) fructose- human serum albumin (HSA) glycation. The analyzed...
Benzimidazoles are important pharmacophores in drug discovery, and currently its derivatives such as flubendazole, omeprazole, astemizole used for the treatment of anthelmintic, ulcerative, histaminic diseases, respectively.The aim current study was to investigate antiglycation activity nitrobenzimidazole against fructose-mediated human serum albumin (HSA) glycation. The also aimed at investigating effects newly identified inhibitors on AGEsinduced intracellular reactive oxygen species (ROS)...
Phakellistatin peptides from marine organisms are the sources of proline-rich cyclic with reported significant antitumor activities. 18 (1), sponge Phakellia fusca, contains three proline-peptide linkages in cis form. We attempted total synthesis natural product 1 through solution-phase macrocyclization approach, as a result, synthetic peptide 2 was obtained rotamer having all proline residues trans-conformation. Here, we describe synthesis, structural, and cytotoxicity studies...