A5018716025- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Cancer therapeutics and mechanisms
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- Crystallography and molecular interactions
- Protein Tyrosine Phosphatases
- Synthesis of Indole Derivatives
- Axial and Atropisomeric Chirality Synthesis
- Natural Antidiabetic Agents Studies
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Reactions of Organic Compounds
- Synthesis of Tetrazole Derivatives
- Synthesis of Organic Compounds
- Hepatitis C virus research
- Influenza Virus Research Studies
- Asymmetric Synthesis and Catalysis
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Respiratory viral infections research
- Glioma Diagnosis and Treatment
- Chemical Reaction Mechanisms
Ankara University
2019-2020
Sana'a University
2019
Hacettepe University
2015
Background/Objectives: Glioblastoma multiforme (GBM), an aggressive and deadly brain tumour, presents significant challenges in achieving effective treatment due to its resistance current therapies poor prognosis. This study aimed synthesise evaluate 23 novel analogues of 3,4-dihydroquinolin-2(1H)-one, designed enhance druggability solubility, investigate their potential as VEGFR2 inhibitors for GBM treatment. Methods: The synthesised compounds were analysed using silico methods, including...
Metabolic dysfunction-associated fatty liver disease (MAFLD) presents a significant global health challenge, characterized by the accumulation of fat and impacting considerable portion worldwide population. Despite its widespread occurrence, effective treatments for MAFLD are limited. The liver-specific isoform pyruvate kinase (PKL) has been identified as promising target developing therapies. Urolithin C, an allosteric inhibitor PKL, shown potential in preliminary studies. Expanding upon...
A highly efficient, regioselective, and environmentally friendly method has been developed for water-mediated synthesis of 2,3,6-trisubstituted pyridines 5,6,7,8-tetrahydroquinolines. The introduced allows easy preparation various polysubstituted 5,6,7,8-tetrahydroquinolines via domino reaction an enolizable ketone, ammonia enones derived from different Mannich bases in mild conditions. Montmorillonite K-10 promoted this one-pot three-component gave both new known good yields. protocol...
Novel methylene-tethered tetrahydroquinolines (THQs) and cyclopenta[$b$]pyridines were synthesized by one-pot multicomponent reactions of Mannich bases, enolizable ketones, NH$_{4}$OAc in water an environmentally friendly K-10 montmorillonite clay-catalyzed reaction. The cytotoxic activities 1-(2-methyl-8-methylene-5,6,7,8-tetrahydroquinolin-3-yl)ethanone (9a), ethyl 2-methyl-8-methylene-5,6,7,8-tetrahydroquinoline-3 carboxylate (9b),...
This review highlights the development of an efficient and practically different catalyst for organic transformation to synthesize valuable 1(5)-substituted 1H-tetrazoles their analogs.
This review presents a systematic and comprehensive survey of the chemical reactivity 3-acyl(aroyl) coumarins.The target compounds are important intermediates for synthesis variety synthetically useful novel heterocyclic systems with different ring sizes such as isoxazole, pyrazole, 3H-triazolium salts, pyrimidine, pyridine, quinolone, benzoxocin, benzoxonin benzoxepin.
An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series alkylated have synthesized via K10 catalyzed reactions these with a variety bases. Environmentally benign catalyst, water-mediated mild reaction conditions, synthesis products are advantages this method.