In this account we present the rapidly expanding bibliography of published researches concerning progress in area pyrazolones chemistry including synthetic strategies and their applications Keywords: Pyrazolinones, Chemistry, Synthesis, Reactions, Applications

Several fused/binary pyrazole quinolinone hybrids are synthesized via tandem reactions and their insecticidal efficacy against S. littoralis A. gossypii evaluated.

In this review we compile and update recent developments in the synthesis, chemical properties, biological importance of organic selenocyanates. The diverse synthetic routes to organoselenocyanates are described first part, including direct indirect cyanoselenation. second reactions organoselenocyanate discussed. These included oxidation-reduction reactions. Further addition selenocyanate carbonitrile group, accompanied with cyanide group loss. compounds exhibit anticancer, antioxidative,...

This review summarizes results from a literature survey concerning the synthesis and reactions of 4-amino-3-mercapto-1,2,4-triazine-5-ones reported by research groups 1983 to mid. 2015.

Abstract Dehydroacetic acid (DHA) was utilized as a fundamental precursor in the synthesis of novel pyrano [4,3‐ b ] pyran and [2,3‐ pyridine systems. Whereas, new series fused polyheteronuclear systems achieved through reaction DHA with active methylene compounds such malononitrile pyrazolone. treatment 1 cyclic ketones involving cyclohexanone cyclododecanone afforded annulated tricyclic system 6 spiro hybrid molecule 7 . Also, cyanoacetamide derivatives 8 11 yielded their corresponding...

Abstract magnified image This review article includes a recent development in the chemistry of 4‐thiazolidinones. Structure, basicity, synthetic aspects, reactions, and applications were also reported.

ABSTRACT Novel chiral analogues of the antioxidant, anti‐inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2‐(chloroseleno)benzoyl chloride with amino compounds. substituent on nitrogen atom did not provide a substantial increase in activities and newly synthesized compounds showed similar to ebselen.

Abstract The focus of our review is on the methods synthesis and chemical reactivity 2-pyridone some derivatives as 2-chloro-3-nicotinonitrile in addition to biological activity moiety.

Abstract This review article is a survey of the literature on aminoisoxazoles. It describes methods synthesis and chemical reactions aminoisoxazoles as building blocks for polyfunctionalized heterocyclic compounds.

The reaction of 5‐amino‐3‐methylisoxazole ( 1 ) with formalin and secondary amines gave the corresponding Mannich bases 3 , 4 5 6 . Alkylation isoxazole derivative hydrochloride unsubstituted isoxazolo[5,4‐ b ]pyridine derivatives 8a 8b via alkylation at position 4. Moreover, coupling different diazonium salts mono bisazo dyes derivative. newly synthesized compounds were screened for their antitumor activity compared 5‐fluorouracil as a well‐known cytotoxic agent using Ehrlich ascites...

The reaction of pyrazolone bearing a β-ketoester moiety with aliphatic dibasic functional reagents in ethanol afforded the binary ring heterocycles 2, 6, and 10. Whereas, when using an excess reagent, dipyrazolo [3,4-c: 3′, 4′-f] [1,2]diazepine derivative 5 was, obtained. On other hand, compound 1 reacted hydrazine hydrate acetic acid, it furnished pyrazolo[3,4-b]pyridine 7 which acts as monofunctional reagent. Also, m-anisidine according to Knorr synthesis gave α,β-unsaturated ketone 9 lieu...

Abstract 3‐Acetylcoumarin ( 1 ) was utilized as a key intermediate for the synthesis of 2‐aminothiazole derivative 3 via bromination to afford acetylbromide 2 followed by treatment with thiourea or Biginelli reaction . Treatment 5‐chloro‐3‐methyl‐1‐phenyl‐1 H ‐pyrazole‐4‐carbaldehyde, 2‐methyl‐4 ‐benzo[ d ][1,3]oxazin‐4‐one, furo[3,4‐ b ]pyrazine‐5,7‐dione 2‐methyl‐5,6,7,8‐tetrahydro‐4 ‐benzothieno[2,3‐ ][1,3]oxazin‐4‐one afforded diazine derivatives 4–7 Also, pyridopyrimidine 8 obtained one...

Abstract The reaction of 5‐amino‐3‐methylisoxazole with appropriate α,β‐unsaturated ketones gave the corresponding isoxazolo[5,4‐ b ]pyridines. Treatment 1 2,6‐dibenzylidenecyclohexanone or 2‐benzylidenedimedone afforded ]quinoline derivatives. 4,6,8,9‐Tetrahydroisoxazolo[5,4‐ ]quinolin‐5‐one derivative was also obtained by multicomponent condensation dimedone and benzaldehyde. Heterocyclic annulation ]pyridine system achieved via benzylidene derivatives indandione, quinuclidone, pyrazolone,...

Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated‐pyridine‐carbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis 2‐chloro‐4,6‐dimethyl‐nicotinonitrile ( 3 ) through reaction acetylacetone malononitrile as starting materials was implemented. The 2‐chloronicotinonitrile with substituted amines to 2‐aminonicotinonitrile also investigated. Fused or binary pyridines tested...

This research work describes the synthesis and biological properties of some novel isolated or fused heterocyclic ring systems with pyrazole, for example; enaminones containing pyrazolone photochromic functional unit, 4‐[(4‐chlorophenylamino)methylene]‐3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5(4 )‐one (3) analogous derivatives 4, 9, 10, also as pyrazolo[3,4‐ b ]pyridine, ]quinoline, pyrazolo[3′,4′:4,5]thieno[2,3‐ c ]pyrazoline ]pyrazole were synthesized characterized. Newly compounds characterized by...

Abstract The biological, therapeutic, and medicinal properties of coumarins (chromen‐2‐ones), its analogs have triggered enormous studies aimed toward growing synthetic routes to these heterocyclic compounds. This review presents a systematic comprehensive survey the method preparation, chemical reactivity, anti‐microbial associated with this system.