A5013556447- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Chemotherapy-induced organ toxicity mitigation
- Diet and metabolism studies
- Nigella sativa pharmacological applications
- Medicinal Plants and Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Medicinal Plants and Neuroprotection
- Healthcare and Venom Research
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Pineapple and bromelain studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Essential Oils and Antimicrobial Activity
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
- Pharmacological Effects of Natural Compounds
Atatürk University
2020-2025
Ondokuz Mayıs University
2023
Alzheimer's disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined activators (CMA) the AD rat model and observed that CMA improves AD-associated histological parameters in animals. promotes mitochondrial fatty acid uptake from cytosol, facilitates oxidation mitochondria, alleviates oxidative stress.
Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent therapeutic option. However, breakthrough is complicated by selectivity issues since exists in four different isoforms. In work, we report that ellagic acid (EA) its derivatives, present numerous fruits vegetables, can inhibit PKL potently selectively. Several polyphenolic analogues EA were synthesized tested to identify the chemical...
Background: Mitochondrial dysfunction and metabolic abnormalities are acknowledged as significant factors in the onset of neurodegenerative disorders such Parkinson’s disease (PD) Alzheimer’s (AD). Our research has demonstrated that use combined activators (CMA) may alleviate dysfunctions stimulate mitochondrial metabolism. Therefore, CMA could potentially be an effective therapeutic strategy to slow down or halt progression PD AD. CMAs include substances glutathione precursors (L-serine...
Abstract Limited advancements in managing malignant brain tumors have resulted poor prognoses for glioblastoma (GBM) patients. Standard treatment involves surgery, radiotherapy, and chemotherapy, which lack specificity damage healthy tissue. Boron-containing compounds, such as boric acid (BA), exhibit diverse biological effects, including anticancer properties. This study aimed to examine whether boron supplementation, BA, can inhibit growth a xenograft animal model. Using MRI-based tumor...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunctionLassociated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
The aim of this study was to investigate the effects Achillea millefolium extract in paclitaxel-induced testicular toxicity rats. groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) intraperitoneally) + (200 orally for 14 consecutive days) and (4) (400 days). Serum levels testosterone, luteinising hormone follicle-stimulating hormone, well total antioxidant capacity oxidant status measured one day after receiving last dose extract. Testicular superoxide...
Aim: Cisplatin is a widely used and highly effective anti-cancer agent one of the limiting side effects cisplatin ocular toxicity. Achillea millefolium, also known as yarrow, plant that has been for many years to treat various health problems including chemotherapy-related toxicities. Methods: The present investigation was designed evaluate biochemical, molecular histopathological Millefolium on cisplatin-induced oxidative inflammatory damage in rats. Twenty-four adult male rats were...
Abstract Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated hepatoprotective mechanism of arbutin (ARB), glycosylated hydroquinone, against cisplatin-induced hepatotoxicity. Methods: Rats were orally administered with ARB (ARB1 = 50 mg/kg; ARB2 100 mg/kg) for 14 consecutive days hepatotoxicity induced by single dose (10 day 15. Three after intraperitoneal...
Parkinson’s disease is a complex neurodegenerative that affects millions of people worldwide. The incidence and prevalence disease, the second most common after Alzheimer’s gradually increasing. Although it an important public health concern, mechanisms related to have not been fully elucidated. One main approaches research on treatment use experimental models. In vitro in vivo models enable investigation disease-related molecular cellular processes testing potential treatments. A variety...
Excessive consumption of sucrose, in the form sugar-sweetened beverages, has been implicated pathogenesis metabolic dysfunctionLassociated fatty liver disease (MAFLD) and other related syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role response to dietary stressors, it was demonstrated that inhibition JNK could potentially be used treatment MAFLD. However, intricate mechanisms underlying these interventions remain incompletely understood given their multifaceted...
The aim of this study was to investigate the molecular, biochemical, and histopathological effects bromelain, which has antioxidant anti-inflammatory properties, against cisplatin-induced ocular toxicity. groups were designed as (1) Control, (2) Cisplatin (7 mg/kg, intraperitoneally), (3) + Bromelain (50 orally for 14 consecutive days), (4) (100 days). activity total capacity (TAC) oxidant status (TOS) levels reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA),...
Alzheimer's disease (AD) is a neurodegenerative characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in brain accompanied synaptic dysfunction neurodegeneration. No effective treatment has been found to slow progression disease. Therapeutic studies using experimental animal models have therefore become very important. Therefore, this study aimed investigate possible neuroprotective effect D-cycloserine L-serine against aluminum chloride (AlCl3)-induced AD...
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data animal studies have contributed to a better understanding the molecular cellular pathways involved in progression NDDs. Previously, we reported that combined activators (CMA), which include precursors nicotinamide adenine dinucleotide glutathione can be utilized alleviate disorders by activating mitochondrial metabolism.
Myokine developmental endothelial locus-1 (DEL-1) has been documented to alleviate inflammation and endoplasmic reticulum (ER) stress in various cell types. However, the effects of DEL-1 on inflammation, ER stress, apoptosis tenocytes remain unclear. Human primary were cultured palmitate (400 μM) plus (0 2 μg/ml) conditions for 24 hours. The expression levels markers cleaved caspase 3, as well phosphorylated 5' adenosine monophosphate-activated protein kinase (AMPK) autophagy markers,...