A5092710047- Medicinal Plant Research
- Computational Drug Discovery Methods
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Metabolomics and Mass Spectrometry Studies
- Phytochemicals and Antioxidant Activities
- Diverse Scientific Research Studies
- RNA regulation and disease
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
Atatürk University
2023-2024
Parkinson’s disease is a complex neurodegenerative that affects millions of people worldwide. The incidence and prevalence disease, the second most common after Alzheimer’s gradually increasing. Although it an important public health concern, mechanisms related to have not been fully elucidated. One main approaches research on treatment use experimental models. In vitro in vivo models enable investigation disease-related molecular cellular processes testing potential treatments. A variety...
Elucidating the intricate interplay between enzymes and natural compounds is essential for designing therapeutic strategies. This study employs advanced computational techniques to explore binding mechanisms quercetin 2,3-dioxygenase (QDO) oroxylin A, revealing specific interaction patterns key residues crucial formation of QDO-oroxylin A complex. Molecular docking simulations revealed a favorable affinity (docking score: -5.6 kcal/mol) Oroxylin active site cavity QDO, which was supported by...