A5014427406- Chemotherapy-induced organ toxicity mitigation
- Carcinogens and Genotoxicity Assessment
- Nigella sativa pharmacological applications
- Drug-Induced Hepatotoxicity and Protection
- Oral health in cancer treatment
- SARS-CoV-2 and COVID-19 Research
- Bone health and treatments
- Bee Products Chemical Analysis
- Neuroendocrine regulation and behavior
- Selenium in Biological Systems
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Viral gastroenteritis research and epidemiology
- Animal Nutrition and Physiology
- Pineapple and bromelain studies
- Toxic Organic Pollutants Impact
- Pharmacology and Obesity Treatment
- Electrochemical sensors and biosensors
- Natural Compound Pharmacology Studies
- Antioxidant Activity and Oxidative Stress
- Apelin-related biomedical research
- Medicinal Plants and Neuroprotection
Erciyes University
2021-2025
Atatürk University
2025
Sivas Cumhuriyet Üniversitesi
2021
Bozok Universitesi
2021
Abstract Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side effects on healthy tissues and cells. Based the undesirable of 5-FU, aim this study was to determine how 5-FU affects lung tissue whether nobiletin has any protective effect. The consisted negative control, Nobiletin, Nobiletin + groups. groups received 10 mg/kg i.g. for 7 days. On day 8, 100 administered i.p. Biochemical immunohistochemical analyses were...
Background: Tramadol, a weak opioid analgesic agent, is known to induce ovarian damage. Previous studies have held oxidative stress responsible for the adverse effects of tramadol on female reproduction. This study examined protective ATP against tramadol-induced damage and reproductive dysfunction in rats. Methods: Rats were divided into four groups (n = 12); healthy (HG), only (ATPG), (TMDG), + (ATMG). was injected intraperitoneally at 25 mg/kg. Tramadol 50 mg/kg initiated one hour after...
Bu çalışmada, sıçanlarda etanol ile indüklenen gastrik ülsere karşı idebenon ve krisinin koruyucu etkileri araştırılmıştır. Yirmi sekiz Sprague-Dawley erkek sıçan dört gruba ayrılmıştır: 1 ml serum fizyolojik alan kontrol grubu, ülser indüklemek için (ET) (5 ml/kg) ET grubu iki tedavi grubu; biri ET'yi takiben (200 mg/kg), diğeri krisin (100 mg/kg) gruplar. Tedaviler oral gavaj yoluyla uygulanmıştır. Gastrik mukozal hasarı tedavilerin mekanizmasını değerlendirmek için, somatostatin...
Hepatotoxicity of pyrazinamide, an antituberculosis drug, limits its therapeutic use and oxidative stress has been implicated in this toxicity. This study investigated the protective effects adenosine triphosphate (ATP), thiamine pyrophosphate (TPP), melatonin, Liv-52, which have previously shown antioxidant activities, on pyrazinamide-induced hepatotoxicity. 36 albino Wistar male rats were divided into randomized six groups; healthy (HG), pyrazinamide (PZG), ATP + (APZG), TPP (TPZG),...
5-fluorouracil (5-FU) is a broad-spectrum drug that has wide range of side effects. Patients may experience severe comorbidities as result these toxic effects, making it impossible for them to continue chemotherapy. Despite the fact various molecules have been experimented, there no literature data on efficacy dexpanthenol (DXP) mitigating effects 5-FU. To investigate protective DXP nephrotoxicity, hepatotoxicity, and intestinal toxicity induced by 5-FU in rats. Twenty-eight male...
The aim of this study was to investigate the effects Achillea millefolium extract in paclitaxel-induced testicular toxicity rats. groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) intraperitoneally) + (200 orally for 14 consecutive days) and (4) (400 days). Serum levels testosterone, luteinising hormone follicle-stimulating hormone, well total antioxidant capacity oxidant status measured one day after receiving last dose extract. Testicular superoxide...
Abstract Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated hepatoprotective mechanism of arbutin (ARB), glycosylated hydroquinone, against cisplatin-induced hepatotoxicity. Methods: Rats were orally administered with ARB (ARB1 = 50 mg/kg; ARB2 100 mg/kg) for 14 consecutive days hepatotoxicity induced by single dose (10 day 15. Three after intraperitoneal...
The aim of this study was to investigate the molecular, biochemical, and histopathological effects bromelain, which has antioxidant anti-inflammatory properties, against cisplatin-induced ocular toxicity. groups were designed as (1) Control, (2) Cisplatin (7 mg/kg, intraperitoneally), (3) + Bromelain (50 orally for 14 consecutive days), (4) (100 days). activity total capacity (TAC) oxidant status (TOS) levels reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA),...
Ischemia-reperfusion-induced (I/R) renal damage is a pathogenic process that starts with ischemia, then progresses through oxidative stress and inflammation. Tocilizumab (TCZ), recombinant human monoclonal antibody produced against the IL-6 receptor, will be tested I/R injury. TCZ known to lower levels of proinflammatory cytokines oxidant mediators while raising amounts antioxidant molecules. Our purpose evaluate biochemical histological effects I/R-induced oxido-inflammatory kidney...
Parkinson's disease (PD) is a chronic neurodegenerative case. As the progresses, response time to doses of levodopa (L-Dopa) becomes shorter and effects drug are severely limited by some undesirable side such as 'on–off' phenomenon. In several diseases, including Parkinson's, nanoparticles can deliver antioxidant compounds that reduce oxidative stress. This study evaluates compares neuroprotective L-Dopa-modified zinc (ZnNPs) in 6-hydroxydopamine (6-OHDA)-induced PD rat model. For this...
The present study investigated the impact of boric acid (BA) and borax (BX) on markers inflammation modifications in miR‑21/PTEN/AKT pathway genes liver kidney tissues Sprague Dawley male rats with sepsis induced by cecal ligation puncture (CLP). A total 60 were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where model was created), 20 mg/kg BX (CLP + BX1), 40 BX2), BA BA1) BA2). Liver analyzed for histopathological changes, immunopositivity tumor...
The role of oxidative stress, as well inflammation in the pathogenesis methotrexate (MTX)-induced oral mucositis, is a known fact. anti-inflammatory, antitumor, antimicrobial, and antioxidant properties taxifolin—the effect we tested against MTX-induced mucosal damage—are known. Objective Evaluating biochemically histopathologically effects taxifolin on methotrexate-induced damage rats. Methodology In taxifolin+MTX (TMTX) group, 50 mg/kg was orally administered to rats by gavage. MTX healthy...
The methanol metabolite that causes hepatotoxicity is formic acid, generating reactive oxygen radical formation and cell damage. Carvacrol an antioxidant monoterpenic phenol produced from Thymus vulgaris. This study aimed to investigate the effects of carvacrol on methanol-induced oxidative liver damage in rats. Eighteen rats were divided into three groups. Methotrexate was administered orally for 7 days methotrexate+methanol (MTM) methotrexate+methanol+carvacrol (MMC) given before cause...