Morphine is implicated in diverse functions, from development to immune modulation the central and peripheral nervous systems. At present time, morphine one of most effective antinociceptive agents used manage pain. It has been extensively clinical management pain due its potent analgesic effect. In this study, vitro vivo inhibitory effects on erythrocyte carbonic anhydrase (CA) were investigated. Human isoenzymes, HCA-I HCA-II, purified by Sepharose-4B affinity chromatography column with a...

The ethanol is a widely consumed as sedative-hypnotic drug throughout the world. In this study, effects of were investigated on carbonic anhydrase (CA) enzyme activities both in vitro human erythrocyte and vivo Sprague-Dawley rat erythrocyte. For anhydrase-I (HCA-I) -II (HCA-II) are purified by Sepharose 4B-L-tyrosine-sulphanilamide affinity chromatography. CA activity was determined colorimetrically using CO(2)-hydration method Wilbur Anderson. Rat blood samples taken from each before after...

How the routine laboratory tests change in terms of coronavirus disease 2019 (COVID-19) was retrospectively analyzed a large group patients. Biochemical, hematological and inflammatory variables totaly 555 (n = 532 non-intensive care unit (non-ICU), n 23 ICU) patients diagnosed with COVID-19 were accessing them through information system. White blood cell (WBC), neutrophil (NEU), platelet ratio, to lymphocyte ratio (NLR), derived NLR (d-NLR), aspartate aminotransferase, urea, creatine kinase...

Abstract Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side effects on healthy tissues and cells. Based the undesirable of 5-FU, aim this study was to determine how 5-FU affects lung tissue whether nobiletin has any protective effect. The consisted negative control, Nobiletin, Nobiletin + groups. groups received 10 mg/kg i.g. for 7 days. On day 8, 100 administered i.p. Biochemical immunohistochemical analyses were...

The current study investigates the biochemical and histopathological effects of taxifolin on acrylamide-induced kidney damage. A 50 mg/kg dose was administered via oral gavage to + acrylamide (TACR) group (n-6) consisting male albino Wistar rats. same volume distilled water used as solvent orally (ACR) healthy (HG) groups. One hour after administration water, a 20 TACR ACR This procedure repeated once day for 30 days. In group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-α),...

Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol antioxidant anti-inflammatory properties. Aims: To determine effects carvacrol on liver injury induced by acrylamide administration in rats. Methods: Rats were divided into three groups six animals each: healthy group (ACR), + (TACR). First, (50 mg/kg) was administered intraperitoneally to CACR group. One hour later, (20 given orally ACR groups. This...

In women, agents used in chemotherapy treatment have side effects such as accelerating follicular depletion and early menopause. Thus, cytotoxic treatments may cause various ranging from partial damage to the ovary premature ovarian failure (POI) infertility. This study aimed investigate protective effect of carvacrol on cisplatin (CIS)-induced reproductive toxicity female rats.The animals were divided four groups; a healthy group (HG), administered only 2.5 mg/kg (CIS); + (CC-50), 100...

AIM: To investigate the effects of adenosine triphosphate (ATP) and melatonin, which have antioxidant anti-inflammatory activities, on potential 5-fluorouracil (5-FU)-induced optic nerve damage in rats. METHODS: Twenty-four rats were categorized into four groups six rats: healthy (HG), 5-FU (FUG), ATP+5-FU (AFU), melatonin+5-FU (MFU). ATP (4 mg/kg) melatonin (10 administered intraperitoneally orally, respectively. One hour after administration, AFU, MFU, FUG injected with (100 mg/kg). once...

Background/objectives: Common carotid artery occlusion can cause oxidant and inflammatory damage to the optic nerve. In this study, effect of sunitinib was investigated, antioxidant anti-inflammatory properties which have been previously reported shown be protective in I/R injury preventing bilateral nerve ischemia–reperfusion (I/R) injuries after unilateral common ligation rats. Methods: 18 Albino Wistar male rats were divided into SG (sham-operated), CCU (clamping unclamping), SCCU...

ABSTRACT 5‐Fluorouracil (5‐FU), one of the most widely used chemotherapy drugs, is known to cause widespread toxicity and irreparable tissue damage. The purpose this work was analyze phytochemical components Prunus laurocerasus (PL) fruit extract using liquid chromatography with tandem mass spectrometry (LC‐MS/MS) look into effectiveness PL pretreatment on 5‐FU‐induced liver study consisted control (C), PL, 5‐FU, PL+5‐FU groups, groups received 500 mg/kg as for seven days. On eighth day, 100...

In this study, we investigated inhibitory effects of some metal ions on human erythrocyte glutathione reductase. For purpose, initially reductase was purified 1051-fold in a yield 41% by using 2', 5'-ADP Sepharose 4B affinity gel and Sephadex G-200 filtration chromatography. SDS polyacrylamide electrophoresis done order to control the purification enzyme. showed single band for A constant temperature (4 degrees C) maintained during process. Enzyme activity determined with Beutler method...

Abstract Aim To investigate the effect of Kineret® on ischemia reperfusion (IR) injury in rat ovaries. Methods Rats were divided into four groups: ovarian IR (IRG); 50 mg/kg + (KIR‐50); 100 (KIR‐100); and sham operation (SOC). KIR‐50 ( n = 10) KIR‐100 groups received an intraperitoneal injection at doses mg/kg, respectively. IRG SOC given distilled water as solvent using same method. The results compared between groups. Results In rats which occurred, oxidant parameters, such malondialdehyde...

Acrolein is a reactive aldehyde that forms during burning of wood and other fuels. It also product lipid peroxidation (LPO) reactions present in cigarette smoke. known to cause oxidative stress inflammatory nerve tissue damage. Lutein tetraterpenoid molecule with antioxidant anti-inflammatory properties. There appear be no studies on the effect lutein vestibulocochlear damage induced by acrolein. The aim this study was investigate acrolein rats using biochemical histopathological methods....

Abstract: Heme oxygenase isozymes, HO‐1 (also known as hsp32) and HO‐2, are the source for formation of putative messenger molecule carbon monoxide (CO), reactive iron, in vitro antioxidant bilirubin. We have developed characterized transgenic (Tg) mice that overexpress stress protein neurons various brain regions. The Tg were generated by use rat cDNA under control neuron‐specific enolase promoter. Except a tendency to an enlarged spleen, did not show gross anatomical changes. Increase...

The inflammatory process plays an important role in the development of cardiovascular complications patients with obstructive sleep apnea syndrome (OSAS). YKL-40/chitinase 3-like protein 1 is a novel biomarker systemic inflammation. This study aimed to investigate whether carotid intima-media thickness (CIMT), useful marker for early atherosclerosis, associated serum levels normotensive and nondiabetic OSAS.The included 40 OSAS age- sex- body mass index-matched healthy controls. Serum YKL-40...

Intestinal mucositis is one of the major problems in patients receiving cancer treatment. Nimesulide a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate effect nimesulide on small intestine induced by methotrexate (MTX) rats. Experimental animals were divided into control group, MTX group (MTXG) nimesulide+MTX administered (NMTXG) eight rats per group. The MTXG groups given distilled water gavage NMTXG was 100 mg/kg orally. After hour, rat oral 5 mg/kg....

Pazopanib is a tyrosine kinase inhibitor that generally used for the treatment of metastatic renal cell cancer and advanced soft tissue sarcoma. It can cause various degrees hepatotoxicity. Our study aimed to investigate effect taxifolin on pazopanib-induced liver toxicity. A total 18 rats were divided into three groups: pazopanib (PP), plus (TPP), control (C) group. Taxifolin was administered TPP (n=6) group with dose 50 mg/kg. Distilled water orally admnistered C PP groups as solvent....

Background.Bevacizumab-induced vascular endothelial growth factor (VEGF) inhibition may lead to a decrease in adenosine triphosphate (ATP) levels, an increase intracellular Na + and Ca 2+ concentrations reactive oxygen species (ROS) generation, as well cell damage. Objectives.To investigate the biochemical histopathological effects of ATP, benidipine ATP combination with on bevacizumab-induced kidney damage rats. Materials methods.Rats were divided into 5 treatment groups: bevacizumab (BVZ)...

Effects of nicotine, and nicotine + vitamin E on glucose 6-phosphate dehydrogenase (G-6PD) activity in rat muscle, heart, lungs, testicle, kidney, stomach, brain liver were investigated vivo vitro partially purified homogenates. Supplementation period was 3 weeks (n = 8 rats per group): [0.5 mg/kg/day, intraperitoneal (ip)]; [75 intragastric (ig)]; control group (receiving only vehicle). The results showed that (0.5 mg/kg, ip) inhibited G-6PD the stomach by 12.5% (p < 0.001), 48% 20.8% 13%...

Background.Hyperglycemia can be considered a determining factor in the development of diabetic neuropathy as well neuropathic pain.There is relationship between excessive production reactive oxygen species (ROS) and pathogenesis pain.Taxifolin, on other hand, flavonoid that has been documented to inhibit ROS production.Objectives.To investigate effects taxifolin, which antioxidant neuroprotective effects, alloxan-induced hyperglycemia-induced pain, biochemically histopathologically....

Information is lacking on the protective effects of thiamine pyrophosphate (TPP) against hyperglycemia-induced retinopathy in rats. This study investigated biochemical and histopathological aspects effect TPP induced by alloxan rats.The rats were separated into a diabetic TPP-administered group (DTPG), diabetes control (DCG) healthy (HG). While DTPG was given TPP, DCG HG administered distilled water as solvent at same concentrations. procedure repeated daily for 3 months. At end this period,...