A5100424887- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Erythrocyte Function and Pathophysiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
- Cellular Mechanics and Interactions
- Heat shock proteins research
- Mitochondrial Function and Pathology
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Tryptophan and brain disorders
- Immune cells in cancer
- Healthcare and Venom Research
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Sphingolipid Metabolism and Signaling
- RNA regulation and disease
- Fibroblast Growth Factor Research
- Microplastics and Plastic Pollution
Chung-Ang University
2008-2024
Chung-Ang University Hospital
2021-2022
Bridge University
2022
Korea Institute of Radiological and Medical Sciences
2022
The University of Texas Health Science Center at Houston
2015
Brown Foundation
2015
Regenerative Medicine Institute
2015
Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response the human health risk assessment. However, these focused on spherical MPs, which smooth edges shape account for less than 1% of MPs nature. Unfortunately, fragment-type very limited remain initial stages. In this study, we studied effect that 16.4 µm fragment type polypropylene (PP) an irregular sharp form naturally environment, had breast cancer....
Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Aβ), which triggers a cellular stress response called unfolded protein (UPR). The UPR signaling pathway defense system for dealing with accumulation misfolded proteins but switches to apoptosis when endoplasmic reticulum (ER) prolonged. ER involved in neurodegenerative diseases including AD, molecular mechanisms stress-mediated Aβ neurotoxicity still remain unknown. Here, we show that treatment SK-N-SH...
Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet signals generated by hemodynamic forces that influence potential remain poorly defined. Here we show fluid shear stress endows long-term multilineage engraftment upon early tissues at embryonic day 9.5, an stage not previously described to harbor HSCs. Effects on hematopoiesis are mediated part a cascade downstream wall involves calcium efflux and stimulation prostaglandin E2...
To determine the apoptotic signaling pathway which tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL/Apo2L) induced, we investigated contribution of reactive oxygen species (ROS), p38 mitogen‐activated protein (MAP) kinase and caspases in human adenocarcinoma HeLa cells. Here show that upon TRAIL/Apo2L exposure there was pronounced ROS accumulation activation MAP kinase, apoptosis followed. Pretreatment with antioxidants such as glutathione or estrogen attenuated...
Abstract 3‐Hydroxykynurenine (3‐HK), an endogenous tryptophan metabolite, is known to have toxic effects in brain. However, the molecular mechanism of toxicity has not been well identified. In this study, we investigated involvement MAPK/extracellular signal‐regulated kinase (ERK) 3‐HK‐induced neuronal cell damage. Our results showed that 3‐HK induced apoptotic death and ERK phosphorylation occurred during death. Inhibition activation using PD98059 considerably increased Furthermore, was...
Abstract Mechanical forces are pervasive in the inflammatory site where dendritic cells (DCs) activated to migrate into draining lymph nodes. For example, fluid shear stress modulates movement patterns of DCs, including directness and forward migration indices (FMIs), without chemokine effects. However, little is known about effects biomechanical on activation DCs. Accordingly, here we fabricated a microfluidics system assess how affect activity DCs during inflammation. Based structure...
Abstract Carbon nanotubes (CNTs) have been suggested as suitable materials for biomedical applications, especially in the neural area. It is essential not only to investigate biocompatibility of CNTs with system but also determine proper methods applying neuronal growth. This work represents first application by electrospun poly( D , L ‐lactic‐co‐glycolic acid) (PLGA) scaffolds a system. We synthesized nanocomposites PLGA and single‐walled carbon functionalized carboxylic acid groups ( c‐...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves as an extracellular signal that triggers apoptosis in tumor cells. To characterize the molecular events involved TRAIL-induced apoptotic signaling, we investigated role of signal-regulated kinase 1/2 (ERK1/2) HeLa cell death. Here show TRAIL-activated ERK1/2 through a tyrosine kinase-dependent pathway, subsequently elevated anti-apoptotic Bcl-2 protein levels. inhibition with PD98059 promoted death downregulation activity...
Although mesenchymal stromal cells (MSCs) show great potential for use in regenerative medicine, their therapeutic efficacy remains limited because of low adaptation efficiency and viability observed clinical trials. To potentiate the survival MSCs after administration vivo, silk fibroin nanofibers (SFNs) were applied as a scaffold. SFNs are biocompatible, biodegradable polymers with tunable architectures mechanical properties. Treatment interferon (IFN)−γ 18 h increased expression...
Myokine developmental endothelial locus-1 (DEL-1) has been documented to alleviate inflammation and endoplasmic reticulum (ER) stress in various cell types. However, the effects of DEL-1 on inflammation, ER stress, apoptosis tenocytes remain unclear. Human primary were cultured palmitate (400 μM) plus (0 2 μg/ml) conditions for 24 hours. The expression levels markers cleaved caspase 3, as well phosphorylated 5' adenosine monophosphate-activated protein kinase (AMPK) autophagy markers,...