A5047838407- Cellular Mechanics and Interactions
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Mesenchymal stem cell research
- Graphene and Nanomaterials Applications
- Periodontal Regeneration and Treatments
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Diverse Topics in Contemporary Research
- Bioactive natural compounds
- Education and Learning Interventions
- Advanced Surface Polishing Techniques
- biodegradable polymer synthesis and properties
- Heat shock proteins research
- Pluripotent Stem Cells Research
- Silk-based biomaterials and applications
- Muscle Physiology and Disorders
- Microplastics and Plastic Pollution
- Traditional Chinese Medicine Analysis
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- RNA Research and Splicing
- Nuclear Receptors and Signaling
Chung-Ang University
2019-2025
Bridge University
2022
Chung-Ang University Hospital
2022
Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response the human health risk assessment. However, these focused on spherical MPs, which smooth edges shape account for less than 1% of MPs nature. Unfortunately, fragment-type very limited remain initial stages. In this study, we studied effect that 16.4 µm fragment type polypropylene (PP) an irregular sharp form naturally environment, had breast cancer....
Patients with estrogen receptor-positive breast cancer undergoing continuous adjuvant hormone therapy often experience delayed recurrence tamoxifen use, potentially causing adverse effects. However, the lack of biomarkers hampers patient selection for extended endocrine therapy. This study aimed to elucidate molecular mechanisms underlying and identify biomarkers. When miRNA expression was assessed in luminal tissues without using NanoString, a significant increase miR483-3p observed samples...
Human mesenchymal stromal cells (MSCs) possess regenerative potential due to pluripotency and paracrine functions. However, their stemness immunomodulatory capabilities are sub-optimal in conventional two-dimensional (2D) culture. To enhance the efficiency therapeutic efficacy of MSCs, an vivo-like 3D culture condition was applied. MSCs were cultured on polystyrene or a gellan gum-based system. In vitro, prostaglandin-endoperoxide synthase 2, indoleamine-2,3-dioxygenase, heme oxygenase 1,...
Abstract Mechanical forces are pervasive in the inflammatory site where dendritic cells (DCs) activated to migrate into draining lymph nodes. For example, fluid shear stress modulates movement patterns of DCs, including directness and forward migration indices (FMIs), without chemokine effects. However, little is known about effects biomechanical on activation DCs. Accordingly, here we fabricated a microfluidics system assess how affect activity DCs during inflammation. Based structure...
Although mesenchymal stromal cells (MSCs) show great potential for use in regenerative medicine, their therapeutic efficacy remains limited because of low adaptation efficiency and viability observed clinical trials. To potentiate the survival MSCs after administration vivo, silk fibroin nanofibers (SFNs) were applied as a scaffold. SFNs are biocompatible, biodegradable polymers with tunable architectures mechanical properties. Treatment interferon (IFN)−γ 18 h increased expression...
Suitable scaffolds with appropriate mechanical and biological properties can improve mesenchymal stromal cell (MSC) therapy. Because silk fibroins (SFs) are biocompatible materials, they were electrospun applied as for MSC Consequently, interferon (IFN)-primed human bone marrow MSCs on SF nanofibers administered into a polymicrobial sepsis murine model. The IL-6 level gradually decreased from 40 ng/mL at 6 h after to 35 24 sepsis. was significantly low 5 in primed nanofibers, 15 the control...
Purpose: Although single-walled nanotubes (SWNTs) with functional groups have been suggested as a potential nanomedicine to treat neuronal disorders, effective routes administer SWNTs not compared thus far. The blood–brain barrier is considerable challenge for the development of brain-targeting drugs, and therefore functionalized SWNT administration needed testing Parkinson's disease (PD) treatment. Here, were evaluated in PD mouse model. Methods: Three different tested Functionalized...
Abstract Excessive production and accumulation of amyloid‐beta (Aβ) in the brain are one hallmarks Alzheimer's disease (AD). Although oxidative stress is known to trigger promote progression AD, molecular relationship between Aβ not yet fully understood. In this study, we demonstrate that microtubule acetylation induced by plays a critical role secretion altering subcellular distribution precursor protein (APP)‐containing lysosomal vesicles. Under stress, both H4‐APP Swe/Ind HEK293T‐APP cell...
Glioma, a type of brain tumor, is influenced by mechanical forces in its microenvironment that affect cancer progression. However, our understanding the contribution compression and associated mechanisms remains limited. The objective present study was to create an environment which human glioma H4 cells experience pressure thereby investigate compressive mechanosensors signaling pathways. Subsequent time‑lapse imaging wound healing assays confirmed 12 h significantly increased cell...
소셜미디어나 네트워킹 사이트와 같은 웹 2.0 기술이 발달하면서 크라우드소싱(crowdsourcing)이 고객과 기업이 상호작용하는 새로운 경영기법으로 각광받고 있다. 크라우드소싱 방법을 통해 일반 고객들은 조직혁신 과정, 즉 아이디어 창출, 제품 또는 서비스 개발에 직접 참여할 수 많은 기업들이 당면한 문제점을 해결하고 고객과의 상호작용을 강화를 위해 오픈 이노베이션을 수행하고 있지만 외식기업에서의 적용 사례에 대한 국내 연구는 전무한 실정이다. 물적·인적 자원이 부족한 외식업체의 경우, 크라우드소싱은 유용하고, 효과적인 혁신전략이 될 이 해외 사례를 핵심성공요인을 도출하여, 업체에 활용가능성을 탐색하는데 목적이 먼저 성공적인 사례로 평가되는 6개 크라우스소싱 관련 자료를 수집하고, MIT 연구센터의 집단지성 유전인자(collective intelligence genome) 체계를 사용하여 분석하였다. 유전인자를 바탕으로 우리는 누가, 왜, 무엇을, 어떻게 크라우드소싱에...