A5040385134- Sepsis Diagnosis and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Maternal and fetal healthcare
- Chemotherapy-induced cardiotoxicity and mitigation
- Congenital Heart Disease Studies
- Hematological disorders and diagnostics
- Frailty in Older Adults
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- Colorectal Cancer Screening and Detection
- Pneumonia and Respiratory Infections
- Ocular Diseases and Behçet’s Syndrome
- Family and Patient Care in Intensive Care Units
- Global Cancer Incidence and Screening
- Cardiac Imaging and Diagnostics
- Palliative Care and End-of-Life Issues
- Diversity and Career in Medicine
- Lipid metabolism and biosynthesis
- Lipoproteins and Cardiovascular Health
- Medical Education and Admissions
- Antibiotic Use and Resistance
- Colorectal Cancer Treatments and Studies
Beth Israel Deaconess Medical Center
2024-2025
Yale University
2020-2024
Allegheny General Hospital
2023
McGill University
2018-2021
Jewish General Hospital
2018-2020
McGill University Health Centre
2019
Royal Victoria Hospital
2019
Royal Victoria Regional Health Centre
2019
Importance Older adults who are hospitalized for COVID-19 at risk of delirium. Little is known about the association in-hospital delirium with functional and cognitive outcomes among older have survived a hospitalization. Objective To evaluate disability impairment over 6 months after discharge COVID-19. Design, Setting, Participants This prospective cohort study involved patients aged 60 years or were between June 18, 2020, 30, 2021, 5 hospitals in major tertiary care system US. Follow-up...
538 Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths and has been associated with significant patient (pt) financial liability, however no study yet examined pt-reported measures toxicity (FT) in this population. We sought to assess FT newly diagnosed HCC identify pt-, disease-, treatment-related factors FT. Methods: Pts were recruited prior treatment initiation during their initial visit at multidisciplinary liver cancer clinic tertiary care center...
Significance Vitamin B12 and folic acid (FA) deficiencies present with symptoms like anemia birth defects, but the underlying mechanism remains unclear. Here, we show that FA antagonize aryl hydrocarbon receptor (AhR), which has been implicated in defects. We found treatments B12/FA rescued mice from AhR agonist-mediated anemia, fatty livers, cleft palates. B12/FA-deficient exhibited higher transcriptional activity faulty erythropoiesis were abrogated deficiency. Last, verified human samples...
Abstract Background Limited and conflicting findings have been reported regarding the association between social support colorectal cancer (CRC) outcomes. We sought to assess influences of marital status living arrangement on survival outcomes among patients with stage III colon cancer. Patients Methods conducted a secondary analysis 1082 prospectively followed in CALGB 89803 randomized adjuvant chemotherapy trial. Marital were both self-reported at time enrollment as, respectively, married,...
PURPOSE We sought to evaluate the independent and interactive associations of planned treatment duration, celecoxib use, physical activity, body mass index (BMI), diabetes mellitus, vitamin B6 with oxaliplatin-induced peripheral neuropathy (OIPN) among patients stage III colon cancer enrolled in a clinical trial. METHODS conducted prospective, observational study 2,450 CALGB/SWOG 80702 trial, randomly assigned 6 versus 12 cycles adjuvant fluorouracil, leucovorin, oxaliplatin chemotherapy or...
Background Behcet's disease (BD) is a rare, multi-systemic inflammatory disorder for which only limited and contradictory data exists in the context of pregnancy. Our objective was to estimate prevalence BD pregnancy evaluate maternal fetal outcomes associated with pregnant women living BD. Methods Using 1999-2013 Healthcare Cost Utilization Project-Nationwide Inpatient Sample from United States, we performed population-based retrospective cohort study consisting pregnancies that occurred...
In this single-center observational study of 118 older adults with advanced cancer who developed non-ventilator hospital-acquired pneumonia, prolonged antibiotic durations (8-14 and ≥15 vs ≤7 d) were not associated reduced adjusted odds 90-day all-cause readmission or death. These data may inform antimicrobial stewardship efforts in palliative care settings.
Background There is an urgent need to better understand the diverse presentations, risk factors, and outcomes of immune checkpoint inhibitor (ICI)-associated cardiovascular toxicity. remains a lack consensus surrounding screening, stratification, clinical decision-making in patients receiving ICIs. Methods We conducted single center retrospective cohort study including 2165 cancer treated with ICIs between 2013 2020. The primary outcome was adverse events (ACE): composite myocardial...
Most older adults hospitalized with COVID-19 survive their acute illness. The impact of hospitalization on patient-centered outcomes, including physical function, cognition, and symptoms, is not well understood. To address this knowledge gap, we collected longitudinal data about these issues from a cohort survivors hospitalization.We undertook prospective study community-living persons age ≥ 60 years who were June 2020-June 2021. A baseline interview was conducted during or up to 2 weeks...
It is unknown how well cardiologists predict which Fontan patients are at risk for major adverse events (MAEs). The purpose of this study was to examine the accuracy cardiologists' ability identify "good Fontan" patient, free from MAE within following year, and compare that predicted cohort who experienced MAE. This prospective, multicenter included ≥10 years with lateral tunnel or extracardiac Fontan. cardiologist asked yes/no "surprise" question: would you be surprised if your patient has...
Background Patients hospitalized with COVID-19 are at significant risk for superimposed bacterial pneumonia. However, diagnosing superinfection is challenging due to its clinical resemblance severe COVID-19. We therefore evaluated whether the immune biomarker, procalcitonin, could facilitate diagnosis of superinfection.Methods retrospectively identified 185 patients who underwent lower respiratory culture; 85 had evidence superinfection. Receiver operating characteristic curve and area under...
Abstract Background Disparities in colon cancer outcomes have been reported across race and socioeconomic status, which may reflect, part, access to care. We sought assess the influences of median household income (MHI) on among patients with similar Methods conducted a prospective, observational study 1206 stage III enrolled CALGB 89803 randomized adjuvant chemotherapy trial. Race was self-reported by 1116 White 90 Black at enrollment; MHI determined matching 973 patients’ home zip codes...