A5019311663- Chemotherapy-induced cardiotoxicity and mitigation
- PI3K/AKT/mTOR signaling in cancer
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Acute Myocardial Infarction Research
- Coenzyme Q10 studies and effects
- Cardiac tumors and thrombi
- Parkinson's Disease Mechanisms and Treatments
- Advanced Breast Cancer Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
- Machine Learning in Healthcare
- Topic Modeling
- Epilepsy research and treatment
- Gastroesophageal reflux and treatments
- Acute Myeloid Leukemia Research
- Artificial Intelligence in Healthcare
- Biochemical effects in animals
- Cancer Immunotherapy and Biomarkers
- Fatty Acid Research and Health
- Chemical Synthesis and Analysis
- Pharmaceutical Economics and Policy
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Coffee research and impacts
Yale University
1990-2024
Temple University Hospital
2024
Cardiovascular Research Center
2023
Miles College
2022-2023
Yale New Haven Hospital
2022
University of New Haven
2022
Rutgers, The State University of New Jersey
2019
Rutgers New Jersey Medical School
2019
Princeton University
2016
The distribution of the VIP receptor in human hippocampus was studied by autoradiography using [3-iodotyrosyl-125I]Vasoactive Intestinal Peptide (VIP) as a ligand, and relationship to peptide (visualized immunocytochemistry) examined hippocampi surgically removed from patients with medically intractable temporal lobe epilepsy (TLE) obtained at autopsy neurologically normal subjects. In TLE extrahippocampal lesions [125I]VIP binding highest dentate molecular layer, lower levels fields Ammon's...
During the Coronavirus disease 2019 (COVID-19) pandemic, reports have emerged of a multisystem inflammatory syndrome in adults (MIS-A). Multisystem can affect various organ systems, including cardiovascular, gastrointestinal, and neurologic systems without significant respiratory involvement.A previously healthy 43-year-old man presented with fevers abdominal pain then rapidly deteriorated into cardiogenic shock. His constellation symptoms along elevated markers setting recent SARS-CoV-2...
Background There is an urgent need to better understand the diverse presentations, risk factors, and outcomes of immune checkpoint inhibitor (ICI)-associated cardiovascular toxicity. remains a lack consensus surrounding screening, stratification, clinical decision-making in patients receiving ICIs. Methods We conducted single center retrospective cohort study including 2165 cancer treated with ICIs between 2013 2020. The primary outcome was adverse events (ACE): composite myocardial...
Background The emergence of PCSK9i (proprotein convertase subtilisin kexin type 9 inhibitor) and icosapent ethyl (IPE) has expanded the role lipid-lowering therapies beyond statins. Despite recommendations by clinical practice guidelines, their national eligibility use rates remain unclear. Methods Results In National Health Nutrition Examination Survey data from 2017 to 2020, we assessed statins, PCSK9i, IPE among US adults according American College Cardiology/American Heart Association...
Coffee is a complex mixture of more than eight hundred compounds with variety health benefits including reducing the risk neurodegenerative diseases such as Alzheimer's and Parkinson's disease. A coffee compound, unrelated to caffeine, called eicosanoyl‐5‐hydroxytryptamide (EHT) has been identified regulator major serine/threonine phosphatase in brain, protein 2A (PP2A). In diseased tissue, PP2A exhibits reduced activity methylation its carboxy‐terminal tail. Previous reports indicate EHT...
Background: Transcatheter aortic valve replacement (TAVR) is a rapidly expanding minimally invasive procedure. Although many centers across the continental US offer TAVR, accessibility consideration given extensive pre- and post-procedural care. We examined access to TAVR amongst Medicare beneficiaries US. Methods: identified providers based on clinician billing records for CPT codes 33361-33369 in 2020 provider dataset, available from Centers Medicaid Services. Residential practice zip were...
Background: Peripheral blood somatic genetic variants such as those in clonal hematopoiesis of indeterminate potential (CHIP) increase the risk both ischemic and non-ischemic cardiomyopathy but mechanisms beyond inflammation are unclear. Research question/Objectives: We sought to understand prevalence impact CHIP extended (ExSV) using a new deep learning algorithm heart failure patients on outcome all-cause mortality leverage novel partition scores identify pathways involved. Methods: ExSV...
A 59-year-old man with diffuse large B-cell lymphoma, recently diagnosed from a renal biopsy, presented to the emergency department melena, dizziness, and epigastric pain. He was tachycardic had hemoglobin level of 6.4 g/dL. Esophagogastroduodenoscopy revealed isolated gastric fundal varices stigmata no esophageal varices. Abdominal ultrasound Doppler showed normal-appearing liver, patent splenic vein hepatic vasculature, thrombosis. managed supportively discharged. positron emission...
Introduction: Anterior wall ST elevation myocardial infarction (STEMI) is caused by occlusion of the left anterior descending (LAD) coronary artery. Proximal LAD occlusions are associated with larger infarcts and more complications. However, there limited data demonstrating a relationship between ECG changes location culprit lesion. Objective: To determine if patterns elevations (STE)/depressions (STD) on 12 lead can predict lesion in an STEMI proximal LAD. Methods: We performed...
Intro: Angiotensin-II (Ang-II) plays an important role in the pathophysiology of various cardiovascular disorders, including cardiomyopathy and hypertension. Angiotensin II type 1 receptor (AT1R) mediates deleterious effects Ang-II can cause vasoconstriction, vascular cardiac remodeling, cell death. Animal models have shown that AT1R signal is obligatory for development virus-induced myocardial injury through proinflammatory action Ang-II. Data from animal studies human case showed...