A5010180960- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Sodium Intake and Health
- Pregnancy and preeclampsia studies
- Cardiovascular Syncope and Autonomic Disorders
- Circadian rhythm and melatonin
- Cardiovascular and exercise physiology
- Nutritional Studies and Diet
- Skin Protection and Aging
- Diet and metabolism studies
- Climate Change and Health Impacts
- Dermatology and Skin Diseases
- Nutrition, Genetics, and Disease
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Risk Factors
- Obesity, Physical Activity, Diet
- Sleep and related disorders
- Diabetes Treatment and Management
- Genetic and phenotypic traits in livestock
- Acne and Rosacea Treatments and Effects
- Genetic Mapping and Diversity in Plants and Animals
- Hormonal Regulation and Hypertension
- Thermoregulation and physiological responses
Signum Biosciences (United States)
2015-2025
Universidade de Vigo
2015-2024
University of Alabama at Birmingham
2009-2024
Galicia Sur Biomedical Foundation
2023-2024
Servicio Gallego de Salud
2023-2024
University of Miami
2024
Miami Transplant Institute
2024
Atlantic Research Institute of Fisheries and Oceanography
2021
University of Toronto
2020
St. Vincent's Birmingham
2020
Clinical studies have documented morning-evening, administration-time differences of several different classes hypertension medications in blood pressure (BP)-lowering efficacy, duration action, safety profile, and/or effects on the circadian BP pattern. In spite these published findings, most hypertensive subjects, including those under combination therapy, are instructed by their physicians and pharmacists to ingest all BP-lowering morning. The potential differential reduction...
The Hygia Chronotherapy Trial, conducted within the clinical primary care setting, was designed to test whether bedtime in comparison usual upon awakening hypertension therapy exerts better cardiovascular disease (CVD) risk reduction.In this multicentre, controlled, prospective endpoint trial, 19 084 hypertensive patients (10 614 men/8470 women, 60.5 ± 13.7 years of age) were assigned (1:1) ingest entire daily dose ≥1 medications at (n = 9552) or all them 9532). At inclusion and every...
Time of ingestion hypertension medications can affect circadian patterns BP, but whether this translates into an effect on clinical outcomes is unknown. Here, in open-label trial, we randomly assigned 661 patients with CKD either to take all prescribed upon awakening or at least one them bedtime. We measured 48-hour ambulatory BP baseline and 3 months after any adjustment treatment or, the least, annually. After a median follow-up 5.4 years, who took BP-lowering medication bedtime had...
Methods based on periodic regression have been designed for the detection of components in short, noisy, and nonequidistant time series (as they are usually present medicine biology). The procedure consists fitting a set (cosine) curves to data, with analyst choosing domain trial periods be analyzed distance between consecutive periods. We here describe an interactive program least-squares rhythmometry written C language Macintosh computer. For any given number at once, is able perform two...
Therapeutic strategies in resistant hypertension include adding another drug or changing drugs search for a better synergic combination. Most patients, however, receive all of their single morning dose. We have evaluated the impact on circadian pattern blood pressure modifying time treatment without increasing number prescribed drugs. studied 250 hypertensive patients who were receiving 3 antihypertensive Patients randomly assigned to 1 2 groups according modification strategy: but keeping...
OBJECTIVE We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, which all are ingested the morning. RESEARCH DESIGN AND METHODS conducted a prospective, randomized, open-label, blinded end point trial on 448 diabetes, 255 men/193 women, mean ± SD age 62.5 10.8 years, randomized to ingest their prescribed upon awakening or of...
Numerous studies have consistently shown an association between blunted sleep-time relative blood pressure (BP) decline (non-dipping) and increased cardiovascular disease (CVD) risk in hypertension. Normotensive persons with a non-dipper BP profile also target organ damage, namely, left ventricular mass wall thickness, reduced myocardial diastolic function, urinary albumin excretion, prevalence of diabetic retinopathy, impaired glucose tolerance. It remains point contention, however, whether...
α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation this at serine 129 believed to promote its aggregation neurotoxicity, suggesting post-translational modification could be therapeutic target. Here, we demonstrate phosphoprotein phosphatase 2A (PP2A) dephosphorylates α-Syn activity greatly enhanced by carboxyl methylation the catalytic C...
There is strong association between chronic kidney disease (CKD) and increased prevalence of hypertension, risk end-organ damage, cardiovascular (CVD). Non-dipping, as determined by ambulatory blood pressure (BP) monitoring (ABPM), frequent in CKD has also been consistently associated with CVD risk. The reported non-dipping highly variable, probably due to relatively small sample sizes, reliance only on a single, low-reproducibility, 24-h ABPM evaluation per participant, definition daytime...
therapeutic target for diminishing CVD risk is uncertain.We investigated whether reduction most associated with progressive decrease of either office or ambulatory awake asleep BP mean..........
Abstract —With the aim to describe daily pattern of blood pressure during trimesters pregnancy in clinically healthy women as well pregnant who developed gestational hypertension or preeclampsia, we analyzed 1494 series systematically sampled by ambulatory monitoring for 48 hours every 4 weeks after first obstetric visit 124 with uncomplicated pregnancies, 55 hypertension, and 23 a final diagnosis preeclampsia. The circadian variation each group trimester gestation was established population...
This study investigated the administration time–dependent antihypertensive efficacy of valsartan, an angiotensin II receptor blocker. We studied 90 subjects (30 men and 60 women), 49.0±14.3 (mean±SD) years age with stage 1 to 2 essential hypertension; they were randomly assigned receive valsartan (160 mg/d) as a monotherapy either on awakening or at bedtime. Blood pressure was measured by ambulatory monitoring every 20 minutes during day 30 night for 48 consecutive hours before after 3...
Previous results have indicated that valsartan administration at bedtime, as opposed to upon wakening, may improve the diurnal: nocturnal ratio of blood pressure without loss in 24-h coverage and efficacy.To investigate time-dependent antihypertensive efficacy non-dipper patients.We studied 148 patients with grade 1-2 essential hypertension, aged 53.0+/-12.6 years, who were randomly assigned receive (160 mg/day) a monotherapy either on awakening or bedtime. Blood was measured every 20 min...
Valsartan administration at bedtime as opposed to on wakening improves the sleep time-relative blood pressure decline toward a more dipper pattern without loss in 24-hour efficacy. Yet be determined is whether this time-dependent efficacy class-related feature, characteristic of all angiotensin receptor blockers or specific only valsartan. Terminal half-life major difference between blockers, being largest ( approximately 24 hours) for telmisartan. This trial investigated antihypertensive We...
Patients with resistant hypertension present high prevalence of a non-dipper blood pressure pattern. Recent results indicate that non-dipping is related partly to the absence 24-hour therapeutic coverage in patients treated single morning doses. Accordingly, we investigated impact treatment time on pattern 700 basis clinic measurements who were studied by 48-hour ambulatory monitoring. Among them, 299 received all their medication awakening, and 401 taking ≥1 antihypertensive drug at...
Alterations in dendrite branching and morphology are present many neurodegenerative diseases. These variations disrupt postsynaptic transmission affect neuronal communication. Thus, it is important to understand the molecular mechanisms that regulate dendritogenesis how they go awry during disease states. Previously, our laboratory showed cypin, a mammalian guanine deaminase, increases number when overexpressed decreases knocked down cultured hippocampal neurons. Here, we report exposure...
Correlation between blood pressure (BP) level and target organ damage, cardiovascular disease (CVD) risk, long-term prognosis is greater for ambulatory BP monitoring (ABPM) than clinical measurements. Nevertheless, the latter continue to be "gold standard" diagnose hypertension, assess CVD evaluate hypertension treatment. Independent ABPM studies have found that elevated sleep-time a better predictor of risk either awake or 24-h mean. A major limitation all previous ABPM-based prognostic...
Independent prospective studies have found that ambulatory blood pressure (BP) monitoring (ABPM) is more closely correlated with target organ damage and cardiovascular disease (CVD) risk than clinic BP measurement. This based on in which was sampled every 15–30 min for ≤24 h, without taking into account reproducibility of any estimated parameter from a time series to be potentially used CVD assessment might depend duration sampling rate. Herein, we evaluated the influence (48 vs. 24 h) rate...
Previous studies established that a single daily dose of olmesartan remains effective for the entire 24 h without alteration day‐night blood pressure (BP) pattern. On other hand, administration valsartan or telmisartan at bedtime, as opposed to upon wakening, improves sleep‐time relative BP decline toward greater dipper pattern loss efficacy. Yet be determined is whether this administration‐time‐dependent efficacy class‐related feature, characteristic all angiotensin‐receptor‐blocker (ARB)...