A5103146631- Chronic Kidney Disease and Diabetes
- Obesity, Physical Activity, Diet
- Pancreatitis Pathology and Treatment
- Atrial Fibrillation Management and Outcomes
- Child Nutrition and Water Access
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Health and Lifestyle Studies
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Birth, Development, and Health
- ECG Monitoring and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Frailty in Older Adults
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Health and Mental Health
- Impact of Technology on Adolescents
- AI in cancer detection
- Cardiovascular Health and Risk Factors
- Diet, Metabolism, and Disease
- Clinical Reasoning and Diagnostic Skills
Yale New Haven Hospital
2024
Yale University
2021-2023
University of New Haven
2023
National Kidney Foundation
2021
Wheelock College
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2016-2018
Phoenix (United States)
2016-2017
National Institutes of Health
2016-2017
Arizona Research Center
2016-2017
Contemporary national clinical practice guidelines recommend direct-acting oral anticoagulants (DOACs) as the first-line anticoagulant strategy over warfarin for most indications, especially among older individuals with an elevated bleeding risk.To evaluate prescribing and DOAC uptake by US clinicians in Medicare population.This retrospective cohort study included all more than 10 prescription claims, who were Provider Utilization Payment Data (2013-2018). analyses conducted between October...
We examined associations of advanced glycation end products (AGEs) with renal function loss (RFL) and its structural determinants in American Indians type 2 diabetes. Data were from a 6-year clinical trial that assessed renoprotective efficacy losartan. Participants remained under observation after the concluded. Glomerular filtration rate (GFR) was measured annually. Kidney biopsies performed at trial. Five AGEs serum collected enrollment kidney biopsy. RFL defined as ≥40% decline GFR...
Inflammation linked to diabetic kidney disease (DKD) may affect white blood cell (WBC) counts and differentials. We examined the cross-sectional associations of total WBC count fractions with structural lesions DKD in 108 Pima Indians Type 2 diabetes who underwent research biopsies. also longitudinal association these variables renal function loss (RFL) 941 Europeans from SURDIAGENE study.Associations morphometric parameters were assessed by linear regression. RFL was defined as≥40%...
Data are lacking on how metabolic risk factors during childhood affect the long-term of type 2 diabetes.
Summary Background and Objectives Most studies describing childhood obesity in the United States are based on cross‐sectional surveys do not include substantial numbers of American Indians (AI). Secular trends height weight reflect general health status. This study describes transitions among AI children over a 43‐year period. Methods Anthropometric data were obtained from prospective conducted southwestern US population (1965 through 2007). For analysis, 12 377 observations available 6529...
To determine whether early administration of losartan slows progression diabetic kidney disease over an extended period.We conducted a 6-year clinical trial in 169 American Indians with type 2 diabetes and urine albumin/creatinine ratio <300 mg/g; 84 participants were randomly assigned to receive 85 placebo. Primary outcome was decline glomerular filtration rate (GFR; iothalamate) ≤60 mL/min or half the baseline value persons who entered GFR <120 mL/min. At enrollment, averaged 165...
To examine the association of bradykinin and related peptides with development diabetic nephropathy lesions in 243 participants type 1 diabetes (T1D) from Renin-Angiotensin System Study who, at baseline, were normoalbuminuric, normotensive had normal or increased glomerular filtration rate (GFR).Plasma concentrations measured baseline by quantitative mass spectrometry. All randomly assigned to receive placebo, enalapril losartan during 5 years between kidney biopsies. Kidney morphometric...
Sleep is increasingly recognized as a vital part of health. Screen time has been linked to sleep quality in children. The purpose this study was analyze associations between screen and characteristics among low-income preschoolers.A total 1,700 preschool-aged children participated at 50 federally state-funded preschool centers Michigan. Baseline measurement for an ongoing longitudinal intervention trial obtained cross-sectional use. At baseline, parents reported the number hours their child...
<b><i>Background:</i></b> Serum amyloid A (SAA) induces inflammation and apoptosis in kidney cells is found to be causing the pathologic changes that are associated with diabetic disease (DKD). Higher serum SAA concentrations were previously increased risk of end-stage renal (ESRD) death persons type 2 diabetes advanced DKD. We explored prognostic value American Indians without DKD or early <b><i>Methods:</i></b> concentration was measured...
Childhood obesity is associated with increased cardiometabolic risk.To study the relationship between body mass index (BMI) and risk factors in American Indian children adolescents.Differences metabolic variables by age sex-specific BMI percentiles (2000 Centers for Disease Control Prevention Growth Charts) were examined a cross-sectional analysis of 2977 individuals across three categories. Children an exam two consecutive categories included longitudinal analysis. Spearman's correlations...
Rapid and irregular ventricular rates (RVR) are an important consequence of atrial fibrillation (AF). Raw accelerometry data in combination with electrocardiogram (ECG) have the potential to distinguish inappropriate from appropriate tachycardia AF. This can allow for development a just-in-time intervention clinical treatments AF events. The objective this study is develop machine learning algorithm that episodes RVR associated low levels activity.This involves 45 patients persistent or...
Studies show that digoxin use is declining but still prevalent. Recent data on prescription and characteristics of prescribers are unknown, which can help understand its contemporary use. Using Medicare Part D 2013-2019, we studied the change in number proportion prescriptions prescribers, overall by specialty. logistic regression, identified prescriber associated with prescription. From total (4.6 to 1.8 million) decreased (9.1% 4.3% overall; 26.6% 11.8% among General Medicine 65.4% 48.9%...
Background: Transcatheter aortic valve replacement (TAVR) is a rapidly expanding minimally invasive procedure. Although many centers across the continental US offer TAVR, accessibility consideration given extensive pre- and post-procedural care. We examined access to TAVR amongst Medicare beneficiaries US. Methods: identified providers based on clinician billing records for CPT codes 33361-33369 in 2020 provider dataset, available from Centers Medicaid Services. Residential practice zip were...
Background: Despite being an essential procedure with rising use in the United States, availability and accessibility of procedural care for a permanent pacemaker are not known. We investigated access to implantation among Medicare beneficiaries. Methods: US physician claims from 2020, county population characteristic data AHRQ were used evaluate density providers beneficiaries across states counties. For each zip code, we determined closest center using haversine formula, then assessed...