Cardiac troponin (Tn) plays a central role in the evaluation of patients with angina presenting acute coronary syndrome. The advent high-sensitivity assays has improved analytic sensitivity and precision serum Tn measurement, but this advancement come at cost poorer specificity. clinical judgment is heightened importance because, more so than ever, interpretation elevation hinges on careful integration findings from electrocardiographic, echocardiographic, physical exam, interview, other...

To compare the outcomes of vascular access (VA) procedures performed using physical examination (PE) alone to PE and ultrasound vein mapping for assessment patients needing hemodialysis access.Comparative analysis data obtained by retrospective review records 63 who underwent (VM) colored Doppler ultrasonography (CDUS) 76 assessed schedule surgery. The parameters study impact these two different pre-operative approaches included selection surgical site, procedure, construction arteriovenous...

<i>β</i>₁ adrenergic receptors (<i>β</i>₁ARs) are central regulators of cardiac function and a drug target for disease. As member the G protein–coupled receptor family, <i>β</i>₁ARs activate cellular signaling by primarily coupling to Gs proteins adenylyl cyclase, cAMP-dependent pathways, multifunctional adaptor-transducer protein <i>β</i>-arrestin. Carvedilol, traditional <i>β</i>-blocker widely used in treating high blood pressure heart failure blocking...

Atrial fibrillation (AF) is the most common arrhythmia, with few treatment options. To discover novel pathways, we performed mass spectrometry (MS) on atrial tissue from patients in Sinus Rhythm or AF without heart failure. We identified changes canonical although surprisingly, contractile proteins and specifically a loss of isoforms. Functional remodeling was confirmed cardiomyocytes, revealing increased contractility compared to SR. MS analysis human ventricular found that ~1/3 proteomic...

&lt;i&gt;Background:&lt;/i&gt; The purpose of the study was to investigate and compare iloprost levosimendan on spinal cord ischemia in an experimental model. &lt;i&gt;Materials Methods:&lt;/i&gt; done two stages. For 4-hour short survival study, 50 New Zealand white rabbits were randomly allocated into five groups. Spinal induced by clamping aorta just below left renal artery proximal aortic bifurcation with bulldog clamps. clamps removed after 40 min restoration blood flow verified...

The role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. objective this study was to examine potential protective effects hyperbaric oxygen (HBO) and iloprost (IL) therapy on lung induced ischemia/reperfusion a rabbit model, using both biochemical histopathological aspects.Forty New Zealand white rabbits were randomly allocated into one five groups: HBO group (single session treatment); IL (25 ng/kg/min infusion IL); + (both Control (0.9% saline...

Dilated cardiomyopathy (DCM) is an inherited disorder often leading to severe heart failure. Linkage studies in affected families have revealed hundreds of different mutations that can cause DCM, with most occurring genes associated the cardiac sarcomere. We developed investigational pipeline for discovering mechanistic genotype-phenotype relationships DCM and here apply it DCM-linked tropomyosin mutation

Hyperbaric oxygen (HBO) has been shown to be effective in preventing neurological injuries animal models of ischaemia, whereas iloprost (IL) prevents ischaemia-related mitochondrial dysfunction and reduces infarction size after focal cerebral ischaemia models. The aim the present study was investigate effect combined HBO IL treatment on spinal cord ischaemia–reperfusion (IR) injury by neurological, histopathological biochemical methods an experimental study. Eighty New Zealand white male...

To investigate whether α-tocopherol and ascorbic acid have effect on the suppression of inflammation in early postoperative period after open heart surgery.A total 59 patients who had undergone cardiopulmonary bypass (CPB) Cardiovascular Surgery Department a tertiary center between June 2008 December were retrospectively investigated. The study group consisted 34 (25 men, 9 women) to whom (500 mg/day) (300 administered day operation (0th day) first four consecutive days. In contrast, 25...

The objective of this study was to demonstrate the role major surgery on patients presenting with vascular complications after lumbar disc surgery. A retrospective analysis seven cases treated surgically in two tertiary care centers between August 2001 and June 2010 carried out. average age (three women four men) 35.8 ± 7.2. most common vessel injured left iliac artery occurring five (71.4%), followed by vein injury detected (28.5%). Transperitoneal approach preferred all primary suturing,...

Mycotic aneurysms occur due to destruction of the vessel wall, either by infection a previously healthy artery or through secondary preexisting aneurysm. Although mycotic are frequent in femoral artery, pseudoaneurysms rare (1, 2). Tianeptine is tricyclic antidepressant with unique mechanism action as glutamatergic modulator. However, tianeptine also known for its abuse and dependence potential (3-5). We hereby report case bilateral pseudoaneurysm intraarterial administration patient drug...

Background Anticoagulant treatment is recently being replaced by more aggressive endovascular modalities in the management of acute deep vein thrombosis (DVT). These techniques have been promoted to improve thrombus removal, prolong venous patency, prevent insufficiency, and reduce post thrombotic syndrome. The aim present study overview short-term results percutaneous mechanical thrombectomy (PMT) for DVT. Methods This retrospective based on data from 21 DVT patients treated with PMT...

Irritable bowel syndrome (IBS), a subgroup of functional somatic disorders, may be associated with autonomic dysfunction (AD). Heart rate variability (HRV), measure dysfunction, predict survival. The aim this study was to investigate the effect IBS on HRV parameters, carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates AD, subclinical atherosclerosis arterial stiffness, respectively.Our cross-sectional observational. Thirty consecutive patients...

Abstract Infundibular stenosis may develop secondary to ventricular septal defect, and transannular patch plasty can affect mortality morbidity rates. Therefore, dextroposition of the aorta has been investigated in order eliminate discrepancies literature. Figures illustrations from selected references have “actual aorta” evaluated as far is visible. A careful examination these figures revealed following tips pearls for accurate diagnosis aorta: Aorta defect should be adjacent a “true”...

The results of surgical approaches are unsatisfactory in patients with a distal arterial bed that is ineligible for revascularization. In this retrospective study, we investigated outcomes who underwent interventions reported to induce angiogenesis.6 diagnosed thromboangiitis obliterans were included study. Of these 6 patients, 2 femoropopliteal bypass surgery using reversed great saphenous vein as conduit. other 4 ascending venous arterialization (bypass from the popliteal artery at level...

Tianeptine is a selective serotonin reuptake enhancer, possessing strong antidepressant and anxiolytic properties. Its relative lack of sedative, anticholinergic cardiovascular side effects makes it highly tolerable substance abuse. However, physical dependence quickly develops withdrawal symptoms are common. Abusers in Georgia Armenia use tianeptine by intravenous injection. Drug abusing behaviour usually starts during puberty, since stems from psychological, social cultural circumstances....

We seek to elucidate the precise nature of mechanical loading that precipitates conduction deficits in a concealed-phase model arrhythmogenic cardiomyopathy (ACM). ACM is progressive disorder often resulting from mutations desmosomal proteins. Exercise has been shown worsen disease progression and unmask arrhythmia vulnerability, yet underlying pathomechanisms may depend on type intensity exercise. Because exercise causes myriad changes multiple inter-dependent hemodynamic parameters, it...