Kenechukwu Mezue

ORCID: 0000-0001-7454-7410
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About
Contact & Profiles
Research Areas
  • Blood Pressure and Hypertension Studies
  • Heart Rate Variability and Autonomic Control
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Function and Risk Factors
  • COVID-19 Clinical Research Studies
  • Heart Failure Treatment and Management
  • Cardiovascular Health and Risk Factors
  • Cardiac Health and Mental Health
  • Cardiovascular Disease and Adiposity
  • Cardiac Arrest and Resuscitation
  • Cardiac pacing and defibrillation studies
  • Cardiovascular Health and Disease Prevention
  • Cardiac Valve Diseases and Treatments
  • Mechanical Circulatory Support Devices
  • Stress Responses and Cortisol
  • Cardiac Structural Anomalies and Repair
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Infective Endocarditis Diagnosis and Management
  • Pulmonary Hypertension Research and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • Streptococcal Infections and Treatments
  • Alcohol Consumption and Health Effects
  • Electrolyte and hormonal disorders
  • Cardiovascular Issues in Pregnancy

Harvard University
2021-2024

Massachusetts General Hospital
2020-2024

Yale University
2022-2024

Temple University Hospital
2024

University of the Commonwealth Caribbean
2020-2021

Morehouse School of Medicine
2021

Cardiovascular Research Associates
2021

Altru Health System
2018-2020

University of North Dakota
2020

Einstein Medical Center Philadelphia
2015-2018

Cardiorenal syndrome encompasses a spectrum of disorders involving both the heart and kidneys in which acute or chronic dysfunction 1 organ may induce other organ. It represents confluence heart-kidney interactions across several interfaces. These include hemodynamic cross-talk between failing response vice versa, as well alterations neurohormonal markers inflammatory molecular signatures characteristic its clinical phenotypes. The mission this scientific statement is to describe...

10.1161/cir.0000000000000664 article EN Circulation 2019-03-11

Abstract Background While growing evidence suggests a link between periodontal disease (PD) and cardiovascular (CVD), the independence of this association pathway remain unclear. Herein, we tested hypotheses that: (1) inflammation periodontium (PD ) predicts future CVD independently risk factors shared PD, (2) mechanism linking two diseases involves heightened arterial inflammation. Methods 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( F‐FDG‐PET/CT) imaging was...

10.1002/jper.19-0441 article EN Journal of Periodontology 2021-01-29

SPRINT (Systolic Blood Pressure Intervention Trial) highlighted the benefits of intensive targeted antihypertensive therapy but resulted in higher rates treatment‐related adverse events. pressure (BP) variability has emerged as a significant predictor outcomes over and above levels BP. Using data set, we aimed to determine relationship BP with cardiovascular side effects therapy. The analyses included all participants randomized who reached target systolic (SBP) for their respective groups...

10.1111/jch.13346 article EN Journal of Clinical Hypertension 2018-07-09

A non-dipping pattern of nocturnal blood pressure in hypertensive patients is an established predictor cardiovascular risk, especially Blacks. However, data on normotensives and risk this population sparse. In study, we aim to determine if a profile cohort Black associated with cardiac target organ damage.We studied ambulatory patterns 43 normotensive Caribbean origin classified their profiles as dippers (DP) non-dippers (NDP) based profiles. Cardiac damage was estimated from 2-D...

10.18865/ed.26.3.279 article EN Ethnicity & Disease 2016-07-20

The outbreak of the novel COVID-19 that began in Wuhan, China, killed a Yanomami (an Amazonian tribe) adolescent on 9 April 2020, presumed to have been contracted from gold miners. Although strong influence environmental conditions such as place residence and socioeconomic status health or illness is irrefutable, scant attention paid interconnectedness people how affect one group ultimately everyone globally. pandemic reminder wake-up call more equitable distribution money, power resources...

10.1136/jech-2020-214755 article EN 2020-10-16

Visit-to-visit blood pressure variability has been associated with adverse cardiovascular outcomes. Using the SPRINT trial data set, we explored relationship between variability, outcomes, and hypoperfusion-related events of antihypertensive therapy in patients chronic kidney disease (CKD) enrolled study.The analyses included CKD randomized who reached target systolic for their respective groups (intensive <120 mm Hg; standard <140 Hg). Coefficients variation (CV) diastolic (DBP) each...

10.1093/ajh/hpx128 article EN American Journal of Hypertension 2017-07-11

Controversy exists as to whether anxiety and depression increase deep vein thrombosis (DVT) risk, the mechanisms mediating potential links remain unknown. We aimed evaluate association between DVT risk determine upregulated stress-related neural activity (SNA), which promotes chronic inflammation, contributes this link. Our retrospective study included adults (N = 118 871) enrolled in Mass General Brigham Biobank. A subset 1520) underwent clinical

10.1002/ajh.27427 article EN American Journal of Hematology 2024-07-04

Renal dysfunction is an important predictor of poor outcomes in patients with heart failure preserved ejection fraction (HFpEF). Right ventricular (RV) implicated as one the explanations for worsening renal function cardiorenal syndrome. Novel right catheterization (RHC) parameters such pulmonary artery pulsatility index (PAPi) and atrial to capillary wedge pressure ratio (RA:PCWP) have been found predictors RV dysfunction. However, most studies investigating these done setting myocardial...

10.1159/000494089 article EN Cardiorenal Medicine 2018-12-13
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