A5063458435- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Sports injuries and prevention
- Cardiovascular Health and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Drug Transport and Resistance Mechanisms
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Ubiquitin and proteasome pathways
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Physical Activity and Health
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
Massachusetts General Hospital
2017-2025
Harvard University
2019-2024
Institute for Clinical Evaluative Sciences
2024
University of California, Los Angeles
2024
Cedars-Sinai Smidt Heart Institute
2024
Cedars-Sinai Medical Center
2024
Vanderbilt University Medical Center
2024
Cardiovascular Research Associates
2023
Middlebury College
2023
Université Laval
2022-2023
Cardiac involvement among hospitalized patients with severe coronavirus disease 2019 (COVID-19) is common and associated adverse outcomes. This study aimed to determine the prevalence clinical implications of COVID-19 cardiac in young competitive athletes.In this prospective, multicenter, observational cohort data from 42 colleges universities, we assessed prevalence, characteristics, outcomes collegiate athletes United States. Data were collected September 1, 2020, December 31, 2020. The...
Importance Guidelines recommend 150 minutes or more of moderate to vigorous physical activity (MVPA) per week for overall health benefit, but the relative effects concentrated vs evenly distributed are unclear. Objective To examine associations between an accelerometer-derived “weekend warrior” pattern (ie, most MVPA achieved over 1-2 days) spread with risk incident cardiovascular events. Design, Setting, and Participants Retrospective analysis UK Biobank cohort study participants providing...
BACKGROUND: Understanding the incidence, causes, and trends of sudden cardiac death (SCD) among young competitive athletes is critical to inform preventive policies. METHODS: This study included National Collegiate Athletic Association athlete deaths during a 20-year time frame (July 1, 2002, through June 30, 2022). Athlete were identified 4 separate independent databases search strategies (National resolutions list, Parent Heart Watch database media reports, Center for Catastrophic Sports...
To assess the prevalence and clinical implications of persistent or exertional cardiopulmonary symptoms in young competitive athletes following SARS-CoV-2 infection.This observational cohort study from Outcomes Registry for Cardiac Conditions Athletes included 3597 US collegiate after infection. Clinical characteristics, advanced diagnostic testing SARS-CoV-2-associated sequelae were compared between with >3 weeks, on return to exercise those without symptoms.Among (mean age 20 years (SD, 1...
Objectives Persistent or late-onset cardiopulmonary symptoms following COVID-19 may occur in athletes despite a benign initial course. We examined the yield of cardiac evaluation, including exercise testing (CPET), with after COVID-19, compared CPETs these and those without evaluated longitudinal changes CPET improvement symptoms. Methods This prospective cohort study young (18–35 years old) referred for that were present>28 days from diagnosis. findings post-COVID matched reference group...
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study COVID-19 patients. Our results identify senescence-associated secretory phenotype, marker of biological aging, as dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator senescence-promoting Activin/TGFβ signaling, ADAMTS13, von Willebrand Factor–cleaving protease whose loss-of-function causes microvascular...
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer a variety of anticancer agents, including taxanes. However, in vivo functions pump have not been determined any extent. In this study, generated and analyzed Abcc10(-/-) mice investigate ability Abcc10 function an endogenous factor. Mouse embryo fibroblasts derived from were hypersensitive docetaxel, paclitaxel, vincristine, cytarabine (Ara-C)...
<h3>Importance</h3> Aortic dilatation is frequently encountered in clinical practice among aging endurance athletes, but the distribution of aortic sizes this population unknown. It additionally uncertain whether may represent adaptation to long-term exercise, similar well-established process ventricular remodeling. <h3>Objective</h3> To assess prevalence masters-level male and female athletes with about 2 decades exercise exposure. <h3>Design, Setting, Participants</h3> This cross-sectional...
Abstract Aims The aim of this study was to define the natural history patients with mitral annular calcification (MAC)-related valve dysfunction and assess prognostic importance mean transmitral pressure gradient (MG) impact concomitant regurgitation (MR). Methods results institutional echocardiography database examined from 2001 2019 for all MAC MG ≥3 mmHg. A total 5754 were stratified by in low (3–5 mmHg, n = 3927), mid (5–10 1476), high (≥10 351) gradient. age 78 ± 11 years, 67% female....
Background Clinical practice recommendations for participation in sports and exercise among young competitive athletes with cardiovascular conditions at risk sudden death are based largely on expert consensus a paucity of prospective outcomes data. Recent guidelines have taken more permissive approach, using shared decision-making model. However, the impact this strategy remain unknown. Methods The ORCCA (Outcomes Registry Cardiac Conditions Athletes) study is prospective, multicenter,...
Abstract Background The shift in mitral stenosis (MS) aetiology from rheumatic to calcific valve disease, commonly seen elderly patients with cardiomyopathy, challenges the differentiation between valve- or tissue-related causes of haemodynamic abnormalities. Purpose This study examines impact left-heart myopathy on echocardiographic assessment MS severity and acute effects following (MV) intervention. Methods CircAdapt model human cardiovascular system was used evaluate effect cardiac...