A5054679219- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- FinTech, Crowdfunding, Digital Finance
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Heart rate and cardiovascular health
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Health and Medical Research Impacts
- Microfinance and Financial Inclusion
- Eosinophilic Disorders and Syndromes
- Nutrition, Genetics, and Disease
- Sharing Economy and Platforms
- Medication Adherence and Compliance
- Pharmacology and Obesity Treatment
- Statistical Methods in Clinical Trials
- Gastroesophageal reflux and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
Broad Institute
2022-2025
Brigham and Women's Hospital
2022-2025
Harvard University
2022-2024
The University of Texas Southwestern Medical Center
2019-2022
Southwestern Medical Center
2021-2022
University of Pennsylvania
2021
University of Oxford
2014
Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify likely to derive net benefit from aspirin therapy is unclear.To examine the association between CAC, bleeding, and ASCVD explore estimated effect of different CAC thresholds.Prospective population-based cohort study Dallas Heart Study participants, free not taking baseline. Data were analyzed February 1, 2020, July 15, 2020.Coronary score...
The win ratio was introduced into cardiovascular trials as a potentially better way of analyzing composite endpoints to account for the hierarchy clinical significance their components and facilitate inclusion recurrent events. basic concept is define importance within outcome, form all possible pairs by comparing every subject in treatment group with control group, then evaluate each pair occurrence outcome descending order importance, starting at most important progressing down if does not...
<h3>Importance</h3> Familial hypercholesterolemia variants impair clearance of cholesterol from the circulation and increase risk coronary artery disease (CAD). The extent to which adherence a healthy lifestyle is associated with lower CAD in carriers noncarriers warrants further study. <h3>Objective</h3> To assess association interaction between familial CAD. <h3>Design, Setting, Participants</h3> This cross-sectional study used 2 independent data sets gene sequencing UK Biobank:...
<h3>Importance</h3> Despite major differences in their health care systems, medical crowdfunding is increasingly used to finance personal costs Canada, the UK, and US. However, little known about campaigns designed raise monetary donations for expenses, individuals who turn crowdfunding, fundraising intent. <h3>Objective</h3> To examine demographic characteristics of beneficiaries, campaign characteristics, association with funding success <h3>Design, Setting, Participants</h3> This...
Hypertension remains the major cardiovascular disease risk factor globally, but variability in measured blood pressure may result suboptimal management. Whether genetic contributors to elevated complementarily inform assessment is unknown.
The U.S. Centers for Disease Control and Prevention (CDC) recognizes that older adults individuals with certain medical conditions are at increased risk of severe COVID-19 infection. Understanding the proportion population infection, including among those heart disease, could assist current vaccine strategy efforts.Using data from 2015-2018 National Health Nutrition Examination Survey (NHANES), we estimated weighted prevalence any eight eleven increased-risk (including age ≥65) in aged ≥18...
<h3>Importance</h3> In 2015, the US Food and Drug Administration approved 2 new medications for treatment of heart failure with reduced ejection fraction, sacubitril/valsartan ivabradine. However, few national data are available examining their contemporary use associated costs. <h3>Objective</h3> To evaluate patterns ivabradine therapeutic spending in Medicare Part D Medicaid. <h3>Design, Setting, Participants</h3> this nationwide claims-based study, we analyzed from Prescription Event...
Background: Current consensus guidelines emphasize the importance of achieving 150 minutes or more moderate to vigorous physical activity (MVPA) per week promote cardiovascular health but give little guidance about sedentary behavior. Research Question: Is behavior associated with (CV) disease in a manner distinct from insufficient activity? Aims: Examine associations between accelerometer-measured risk specific CV outcomes, including potential interactions MVPA. Methods: Using 89,530...
Graphical AbstractPathophysiology and stratification of arrhythmic risk post-myocardial infarction. (A) Formation scar substrate infarction possible factors contributing to future arrhythmogenicity. (B) Current proposed approach sudden cardiac death Abbreviations: AI, artificial intelligence; CMR, magnetic resonance imaging; EPS, electrophysiological study. Figure created with BioRender.com Adobe IllustratorOpen in new tabDownload slide
Abstract Background Medical crowdfunding is increasingly used to finance personal healthcare costs in Canada (CAN), United Kingdom (UK), and States (US) despite major differences their systems. Yet, it lacks comparative descriptive research guide policy changes that can promote equitable accessible healthcare. Methods We conducted a cross-sectional analysis of Canadian, British, American campaigns between February 2018 March 2019 on the GoFundMe platform (n=3,396). extracted manually...
Abstract Background Atrial fibrillation (AF) is a common and morbid arrhythmia. Despite substantial heritable component, genetics does not currently play role in personalized medicine for AF. Rare genetic variants genes associated with inherited cardiomyopathies (CMP) are enriched AF patients. However, prior studies on rare mainly relied hospital-based populations, knowledge clinical outcomes remains limited. Purpose We aimed to evaluate the potential diagnostic yield prognostic implication...
Background: Medical crowdfunding is increasingly used to finance personal healthcare costs in Canada (CAN), United Kingdom (UK), and States (US) despite major differences their systems. Yet, it lacks comparative descriptive research guide policy changes that can promote equitable accessible healthcare. Methods: We conducted a cross-sectional analysis of Canadian, British, American campaigns between February 2018 March 2019 on the GoFundMe platform (n=3,396). extracted manually reviewed...
Aung Myat, Ezimamaka Ajufo, and Sarah Clarke provide a guide to the five main cardiology subspecialties
Introduction: Hypertension remains the major cardiovascular disease (CVD) risk factor, but variability in blood pressure (BP) may result suboptimal management. Whether genetic contributors to high BP complementarily inform CVD assessment is unknown. We examined by polygenic score (PRS) independent of measured BPs and antihypertensives. Methods: A total 331,078 unrelated UK Biobank study participants without prior were studied. Exposures included PRS stratified normal (systolic [SBP] <130...