A5090629346- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Paraoxonase enzyme and polymorphisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Obesity, Physical Activity, Diet
- Peroxisome Proliferator-Activated Receptors
- Cerebrovascular and Carotid Artery Diseases
- Cholesterol and Lipid Metabolism
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
Lund University
2024
Palo Alto Institute
2021
Imperial College London
2021
Southwestern University
2015-2020
Cleveland Clinic
2020
Rabin Medical Center
2019
Louisiana State University System
2018
Duke University
2018
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL efflux capacity, the ability of to accept from macrophages, which key step reverse transport. We investigated epidemiology capacity and its association with incident atherosclerotic cardiovascular disease outcomes large, multiethnic population cohort.We measured level, particle concentration, at baseline 2924 adults free who were...
<h3>Context</h3>Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk death adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.<h3>Objectives</h3>To determine prevalence determinants a new highly sensitive assay to assess whether measured associate pathological phenotypes subsequent mortality.<h3>Design, Setting, Participants</h3>Cardiac were both assays 3546...
Resistin, a plasma protein, induces insulin resistance in rodents. Recent reports suggest that circulating levels of resistin are elevated obese and insulin-resistant rodents humans. Whereas rodent is made adipocytes, macrophages major source human resistin. Given the convergence adipocyte macrophage function, may provide unique insight into links between obesity, inflammation, atherosclerosis humans.We examined whether were associated with metabolic inflammatory markers, as well coronary...
Visceral (VAT) and abdominal subcutaneous (SAT) adipose tissues contribute to obesity but may have different metabolic atherosclerosis risk profiles. We sought determine the associations of VAT SAT mass with markers cardiac in a large, multiethnic, population-based cohort obese adults.Among participants Dallas Heart Study, we examined cross-sectional mass, assessed by magnetic resonance imaging (MRI) indexed body surface area (BSA), circulating biomarkers insulin resistance, dyslipidemia,...
Background— Cardiorespiratory fitness (fitness) is associated with cardiovascular disease (CVD) mortality. However, the extent to which improves risk classification when added traditional factors unclear. Methods and Results— Fitness was measured by Balke protocol in 66 371 subjects without prior CVD enrolled Cooper Center Longitudinal Study between 1970 2006; follow-up extended through 2006. Cox proportional hazards models were used estimate of mortality a factor model (age, sex, systolic...
Background: The associations of low-density lipoprotein cholesterol (LDL-C) with cardiovascular disease (CVD) and coronary heart mortality in an exclusively low estimated 10-year risk group are not well delineated. We sought to determine the long-term various LDL-C non–high-density (HDL-C) thresholds CVD a large, cohort. Methods: study sample included participants CCLS (Cooper Center Longitudinal Study) without history or diabetes mellitus defined as (<7.5%) for atherosclerotic events at...
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular risk. HDL-C is also associated with risk of inflammatory disorders, malignancy, diabetes, other diseases. This epidemiologic evidence has not translated to raising as a viable therapeutic target, partly because does reflect (HDL) function. Mendelian randomization analyses have found no causal relationship between...
Abstract BACKGROUND Growth differentiation factor 15 (GDF-15) is produced by cardiomyocytes and atherosclerotic lesions under stress conditions. Although higher circulating GDF-15 concentrations are associated with mortality across a spectrum of cardiovascular conditions, the relationship atherosclerosis in general population remains undefined. METHODS We measured plasma 3219 participants Dallas Heart Study, sample adults ages 30–65 years (55% women, 49% black). was analyzed prespecified...
Background: Few data are available comparing cardiovascular disease (CVD) biomarker profiles between women and men in the general population. We analyzed sex-based differences multiple biomarkers reflecting distinct pathophysiological pathways, accounting for CVD risk factors, body composition, cardiac morphology. Methods: A cross-sectional analysis was performed using from Dallas Heart Study, a multiethnic population-based study. Associations sex 30 representative of 6 categories were...
Transthoracic echocardiography (TTE) accounts for almost half of all cardiac imaging services and is a widely available versatile tool. Appropriate use criteria (AUC) were developed to improve patient care health outcomes. Prior studies have shown that most TTEs are appropriate by AUC. However, the associations among TTE, AUC, their clinical impact not been well explored.To describe proportion affect in an academic medical center overall subgroups defined as inappropriate AUC.Retrospective...
Background The incidence and clinical manifestations of cardiovascular disease (CVD) differ between blacks whites. Biomarkers that reflect important pathophysiological pathways may provide a window to allow deeper understanding racial differences in CVD. Methods Results study included 2635 white black participants from the Dallas Heart Study who were free existing Cross-sectional associations race 32 biomarkers evaluated using multivariable linear regression adjusting for age, traditional...
Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify likely to derive net benefit from aspirin therapy is unclear.To examine the association between CAC, bleeding, and ASCVD explore estimated effect of different CAC thresholds.Prospective population-based cohort study Dallas Heart Study participants, free not taking baseline. Data were analyzed February 1, 2020, July 15, 2020.Coronary score...
OBJECTIVE To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis. RESEARCH DESIGN AND METHODS Using data from Dallas Heart Study, a probability-based population sample, plasma levels of sRAGE artery calcium (CAC) was assessed among 2,571 subjects with complete imaging data. RESULTS An inverse graded observed quartiles CAC, CAC prevalence 28.5% in quartile 1 compared 15.7% 4 (P &lt; 0.0001). After...
High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle (HDL-P) may better predict risk. The associations of HDL-C and HDL-P with ischemic stroke myocardial infarction (MI) among women Blacks have not been well studied. We hypothesized that would consistently be associated MI compared HDL-C.We analyzed individual-level participant data a pooled cohort 4 large population...
Importance The prevalence of antiphospholipid antibodies (aPL) and their association with future atherosclerotic cardiovascular disease (ASCVD) risk has yet to be thoroughly investigated. Objective To determine the between measurements aPL at a single time point ASCVD in diverse population. Design, Setting, Participants This cohort study measured 8 (anticardiolipin [aCL] IgG/IgM/IgA, anti–beta-2 glycoprotein I [aβ2GPI] antiphosphatidylserine/prothrombin [aPS/PT] IgG/IgM) by solid-phase...
Despite data suggesting that apolipoprotein B (apoB) measurement outperforms low-density lipoprotein cholesterol level in predicting atherosclerotic cardiovascular disease risk, apoB has not become widely adopted into routine clinical practice. One barrier for use of is lack consistent guidance clinicians on how to interpret and apply results context. Whereas guidelines have often provided clear targets or triggers initiate treatment change, are lacking. In this review, we synthesize...