A5018180754- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Cardiovascular Health and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Machine Learning in Healthcare
- ECG Monitoring and Analysis
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Pharmaceutical Practices and Patient Outcomes
- Mobile Health and mHealth Applications
- Heat shock proteins research
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Liver Disease and Transplantation
- Diabetes Management and Research
- Pharmaceutical Economics and Policy
- Regulation of Appetite and Obesity
- Coronary Interventions and Diagnostics
- Phonocardiography and Auscultation Techniques
- Extracellular vesicles in disease
- Medication Adherence and Compliance
Brigham and Women's Hospital
2022-2024
Yale University
2021-2023
Harvard University
2022-2023
Yale New Haven Hospital
2021-2022
University of New Haven
2022
Mayo Clinic
2017-2020
Mayo Clinic in Arizona
2020
Mayo Clinic in Florida
2019
WinnMed
2019
Tehran University of Medical Sciences
2012-2017
Importance Wearable devices may be able to improve cardiovascular health, but the current adoption of these could skewed in ways that exacerbate disparities. Objective To assess sociodemographic patterns use wearable among adults with or at risk for disease (CVD) US population 2019 2020. Design, Setting, and Participants This population-based cross-sectional study included a nationally representative sample from Health Information National Trends Survey (HINTS). Data were analyzed June 1...
Left ventricular (LV) systolic dysfunction is associated with a >8-fold increased risk of heart failure and 2-fold premature death. The use ECG signals in screening for LV limited by their availability to clinicians. We developed novel deep learning-based approach that can images the dysfunction.
Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, its efficacy is currently being tested clinical trials for patients with disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) deliver genes, microRNAs proteins recipient cells, acting as mediators MSC paracrine actions. In this context, it critical characterize the MSC-derived EV cargo elucidate their potential...
Background SGLT-2 (sodium glucose transporter-2) inhibitors and GLP-1RAs (glucagon-like peptide-1 receptor agonists) effectively lowered cardiovascular risk in large clinical trials for patients with type 2 diabetes mellitus at high these complications, have been recommended by guidelines. To evaluate the contemporary landscape which recommendations would be implemented, we examined use of medications according to guideline practice. Methods Results In National Health Nutrition Examination...
Smartphone-based health applications are increasingly popular, but their real-world use for cardiovascular risk management remains poorly understood.
Metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. The potential involvement of podocyte damage in early MetS remains unclear. Mitochondrial dysfunction an important determinant damage, but whether it contributes to MetS-related injury unknown. Domestic pigs were studied after 16 wk diet-induced MetS, treated the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for last month diet, lean controls...
Here, we aimed to study serum heat shock protein (HSP) 70 levels in diabetic patients with and without albuminuria. We performed a 1:1 matched case control on 40 albuminuria as cases age, sex, body mass index (normoalbuminuria) controls. Normoalbuminuria was defined urinary albumin excretion rate <15 mg/12 h, between 100-400 h. Patients had higher HSP70 than controls (0.83 ± 0.50 vs. 0.63 0.06; p = 0.02), while they did not differ any other studied variables. In ten of the pairs, (reverse...
In vitro and in vivo studies have shown conflicting results regarding heat shock protein (HSP) leptin correlation. More importantly both HSP70 are correlated with C reactive proteins. The purpose of the present study was to correlation between serum levels patients type 2 diabetes stratified according gender. We performed a cross sectional on established groups defined as 1: long standing for more than 3 years; 2: newly diagnosed within recent 6 months who were not any glucose lowering...
Scattered tubular-like cells (STCs) contribute to repair neighboring injured renal tubular cells. Mitochondria mediate STC biology and function but might be by the ambient milieu. We hypothesized that microenviroment induced ischemic metabolic components of renovascular disease impairs mitochondrial structure in swine, which can attenuated with mitoprotection. CD24 + /CD133 STCs were quantified pig kidneys after 16 wk syndrome (MetS) or lean diet (Lean) without concurrent artery stenosis...
Heat shock proteins (HSPs) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The authors aimed to study applicability heat protein 70 (HSPA1A) serum levels as a diagnostic factor and severity indicator patients with RA quantify cut-off point that predicts status highest specificity. A total 76 36 healthy adults were studied this case-control analysis. Patients had higher HSPA1A level than control group (0.78 ± 0.13 vs. 0.12 0.02 ng/mL, p = 0.006), irrespective...
Wide pulse pressure (PP) is an independent predictor of coronary heart disease (CHD). However, the linearity relation between PP and CHD was not examined before. We aimed to examine this in patients with type 2 diabetes and/or hypertension.A total 3120 (including 2607 1586 hypertension) were followed for 7.8 years. Physician-adjudicated first hard event primary outcome. Cox regression analysis used investigate association incident CHD. Restricted cubic splines nonlinear relations.Four spline...
Objective: Renovascular disease (RVD) produces chronic underperfusion of the renal parenchyma and progressive ischemic injury. Metabolic abnormalities often accompany ischemia, are linked to poorer outcomes. However, mechanisms injury in kidneys exposed metabolic components RVD incompletely understood. We hypothesized that coexisting artery stenosis (RAS) syndrome (MetS) would exacerbate mitochondrial damage, aggravating poststenotic kidney swine. Methods: Domestic pigs were studied after 16...
Oxidized low-density lipoprotein (ox-LDL) plays a principal role in diabetes complications, though ox-LDL concentrations and its functions are dependents of other oxidative anti-oxidative particles. The oxLDL to ratio (ox-LDL/LDL) high-density (ox-LDL/HDL) as new lipid biomarkers may serve good estimation oxidation anti-oxidation type 2 mellitus. aim this study was first examine ox-LDL/LDL ox-LDL/HDL levels patients with mellitus compared control group evaluate their diagnostic accuracies,...
Magnesium is a cofactor for numerous metabolic enzymatic reactions. It required glucose utilization and insulin signaling. We compared plasma magnesium concentrations in pregnant women with without abdominal obesity, investigated the interactive roles of obesity development gestational diabetes mellitus (GDM). Pregnant (n = 40 each group) were followed during gestation. Oral tolerance tests (OGTT) performed at 24-28 weeks pregnancy to diagnose GDM. Plasma glucose, insulin, triglycerides,...
Abstract Aim Achieving the optimal apposition of coronary stents during percutaneous intervention is not always feasible. The risks and benefits stent postdilation in primary (PPCI) patients with ST‐elevation myocardial infarction (STEMI) have remained controversial. We sought to evaluate immediate angiographic long‐term outcomes without postdilation. Methods A cohort ( n = 1,224) STEMI, treated PPCI 500 postdilated; 724 controls), were studied. flow grade, blush frame count considered...
AimsRheumatoid Arthritis (RA) is a model of chronic inflammatory disease. In this study we evaluated the correlation leptin and CRP in patients with RA normal controls.Main methodsA total 75 40 healthy adults were recruited case-control study. categorized into high (DAS–28 > 3.2) low activity (DAS ≤ group according to their DAS-28 score.Key findingsLeptin level was significantly correlated controls (r = 0.365; p < 0.05), but lost 0.095, 0.41). Patients had higher serum levels compared (P...