A5082108008- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Pharmacology and Obesity Treatment
- Parkinson's Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Hypothalamic control of reproductive hormones
- Fibroblast Growth Factor Research
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Parathyroid Disorders and Treatments
University of Amsterdam
2015-2024
Amsterdam University Medical Centers
2018-2024
Amsterdam Neuroscience
2019-2024
Netherlands Institute for Neuroscience
2003-2023
Royal Netherlands Academy of Arts and Sciences
2017-2023
Amsterdam UMC Location University of Amsterdam
2009-2018
University Medical Center Utrecht
2005-2015
European Union
2014
Utrecht University
2006-2013
University of California, San Francisco
2003-2006
The effects of adrenal corticosteroids on subsequent adrenocorticotropin secretion are complex. Acutely (within hours), glucocorticoids (GCs) directly inhibit further activity in the hypothalamo–pituitary–adrenal axis, but chronic actions (across days) these steroids brain excitatory. Chronically high concentrations GCs act three ways that functionally congruent. ( i ) increase expression corticotropin-releasing factor (CRF) mRNA central nucleus amygdala, a critical node emotional brain. CRF...
Abstract Opposing parasympathetic and sympathetic signals determine the autonomic output of brain to body change in balance over sleep‐wake cycle. The suprachiasmatic nucleus (SCN) organizes activity/inactivity cycle behaviors that go along with it, but it is unclear how hypothalamus, particular SCN, its high daytime electrical activity, influences this differentiated balance. In a first series experiments, we visualized hypothalamic pre‐sympathetic neurons by injecting retrograde tracer...
The suprachiasmatic nucleus (SCN), the biological clock, is responsible for a 24-h rhythm in plasma glucose concentrations, with highest concentrations toward beginning of activity period. To investigate whether SCN also daily fluctuations uptake and to examine how these relate SCN-intact rats SCN-lesioned were injected intravenously bolus at different time points. We found an increase period, followed by gradual reduction end variation tolerance seemed not be caused insulin responses...
At present it is not clear which factors are responsible for the diurnal pattern of plasma leptin levels, although timing food intake and circulating hormones such as glucocorticoids insulin have both been proposed independent determinants. In this study we show that ablation biological clock by thermal lesions hypothalamic suprachiasmatic nucleus (SCN) completely eliminates levels. By contrast, removal corticosterone signal adrenalectomy replacement did affect More importantly, nocturnal...
Abstract In order to drive tissue‐specific rhythmic outputs, the master clock, located in suprachiasmatic nucleus (SCN), is thought reset peripheral oscillators via either chemical and hormonal cues or neural connections. Recently, daily rhythm of plasma glucose (characterized by a peak before onset activity period) has been shown be directly driven SCN, independently SCN control feeding behaviour. Indeed, variation was not impaired unless scheduled regimen (six‐meal schedule) associated...
American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar fat consumption have been implicated as a cause hepatic steatosis obesity but the effect meal pattern is largely understudied. We hypothesized that high frequency, compared consuming large meals, detrimental in accumulation intrahepatic abdominal fat. To test this hypothesis, we randomized 36 lean, healthy men 40% hypercaloric diet for 6 weeks or eucaloric control measured triglyceride content...
Highlights•The presence of hepatic steatosis is associated with insulin resistance•Intrahepatic triglycerides are not sufficient for resistance•Diacylglycerol in cytosol predicts inhibition glucose production•Diacylglycerol-associated resistance characterized by PKCε translocationSummaryHepatic lipid accumulation has been implicated the development resistance, but translational evidence humans limited. We investigated relationship between liver fat and tissue-specific sensitivity 133 obese...
Modulation of the striatal dopamine system affects glucose metabolism in humans and mice.
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via butyrate production. Human bariatric surgery data suggest the gut-brain axis is also involved this process, but underlying mechanisms remain unknown.We compared effect of fecal transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin (SERT) binding as well stable isotope-determined...
Plasma glucose concentrations display a daily rhythm generated by the hypothalamic biological clock, located in suprachiasmatic nucleus (SCN). How SCN orchestrates this is unknown. Because glucagon stimulates hepatic production, we hypothesized that if has rhythm, then it may be responsible for rhythm. From hourly blood samples, determined intact and SCN-lesioned rats. Intact ad libitum–fed rats showed clear fasting resulted an even more pronounced It interesting decrease concentrations,...