Anouk Schrantee
A5010718326- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Hemoglobinopathies and Related Disorders
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Diet and metabolism studies
- Neural dynamics and brain function
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Neurotransmitter Receptor Influence on Behavior
- Health, Environment, Cognitive Aging
- Obsessive-Compulsive Spectrum Disorders
- Regulation of Appetite and Obesity
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Tryptophan and brain disorders
- Neurological Complications and Syndromes
- Stress Responses and Cortisol
- Iron Metabolism and Disorders
- Memory and Neural Mechanisms
- Cardiovascular Disease and Adiposity
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2019-2025
Amsterdam Neuroscience
2019-2025
Amsterdam UMC Location University of Amsterdam
2015-2024
Emma Kinderziekenhuis
2022
Stanford University
2021
KU Leuven
2021
University of Calgary
2021
Churchill Hospital
2021
University of Oxford
2021
Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related ADHD using large-scale studies. Methods: Cortical thickness surface area (based on the Desikan–Killiany atlas) were compared between case subjects (N=2,246) control (N=1,934) for children, adolescents, separately ENIGMA-ADHD, a...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
Abstract Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between and structure using structural MRI ( n = 6420) genetic data 3907) from ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical subcortical abnormalities in both mass-univariate multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found...
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of acquisition quantification. In community-wide effort towards robust reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers scanners. The procedures used in ExploreASL capitalize published processing advancements address challenges multi-center datasets...
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via butyrate production. Human bariatric surgery data suggest the gut-brain axis is also involved this process, but underlying mechanisms remain unknown.We compared effect of fecal transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin (SERT) binding as well stable isotope-determined...
Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings been contradictory and based on small samples. Here, we performed the largest ever analysis left-right ADHD, using 39 datasets ENIGMA consortium.
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
Clinically effective drugs against human anxiety and fear systematically alter the innate defensive behavior of rodents, suggesting that in humans these emotions reflect adaptations. Compelling experimental evidence for this theory is yet to be obtained. We report clearest test date by investigating effects 1 2 mg anti-anxiety drug lorazepam on intensity threat-avoidance 40 healthy adult volunteers (20 females). found modulated participants' a dose-dependent manner. However, pattern depended...
Abstract Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in MDD patients, whether this process clinical characteristics a large multi-center international dataset. Methods performed mega-analysis by pooling measures derived from T1-weighted MRI scans 29 samples worldwide. Normative was estimated predicting chronological age (10-75 years) 7 subcortical volumes, 34...
Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown differences brain anatomy between people with major depressive disorder healthy control subjects, few specifically examined anatomical asymmetry relation to this disorder, results from those remained inconclusive. At functional level, some electroencephalography indicated left fronto-cortical hypoactivity right parietal disorders, so...
BackgroundMethylphenidate (MPH) is highly effective in treating attention-deficit/hyperactivity disorder (ADHD). However, not much known about its effect on the development of human brain white matter (WM).PurposeTo determine whether MPH modulates WM microstructure an age-dependent fashion a randomized double-blind placebo-controlled trial (Effects Psychotropic Medication Brain Development-Methylphenidate, or ePOD-MPH) among ADHD referral centers between October 13, 2011, and June 15, 2015,...
Although numerous children receive methylphenidate hydrochloride for the treatment of attention-deficit/hyperactivity disorder (ADHD), little is known about age-dependent and possibly lasting effects on human dopaminergic system.To determine whether system are modified by age to test hypothesis that young but not adult patients with ADHD induces cerebral blood flow response dopamine challenge, a noninvasive probe function.A randomized, double-blind, placebo-controlled trial (Effects...
Several diffusion tensor imaging (DTI) studies in attention deficit hyperactivity disorder (ADHD) have shown a delay brain white matter (WM) development. Because these were mainly conducted children and adolescents, WM abnormalities been assumed, but not proven to progress into adulthood. To provide further insight the natural history of maturation ADHD, we here investigated modulating effect age on adults. 120 stimulant-treatment naive male ADHD (10-12 years age) adults (23-40 with...
Abstract Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms ADHD into adulthood. Although a large literature implicates structural brain differences the disorder, it is not clear if adults with similar neuroanatomical as those seen in recent reports from ENIGMA-ADHD consortium finding for but adults. This paper uses deep learning neural network classification models determine there are changes brains...
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective for major depressive disorder (MDD). We tested and compared machine learning-based methods that predict individual-level pharmacotherapeutic using cortical morphometry from multisite longitudinal cohorts. conducted international analysis pooled data six sites ENIGMA-MDD consortium (n = 262 MDD patients; age 36.5 ± 15.3 years; 154 (59%) female; mean...
Dexamphetamine (dAMPH) is not only used for the treatment of attention deficit hyperactivity disorder (ADHD), but also as a recreational drug. Acutely, dAMPH induces release predominantly dopamine (DA) in striatum, and cortex both DA noradrenaline. Recent animal studies have shown that chronic administration can induce changes system following long-term exposure, evidenced by reductions transporters, D2/3 receptors endogenous levels. However, limited number investigated effects human brain....
Abstract Context Sodium-glucose cotransporter-2 inhibitors (SGLT2i) cause less weight loss than expected based on urinary calorie excretion. This may be explained by SGLT2i-induced alterations in central reward and satiety circuits, leading to increased appetite food intake. Glucagon-like peptide-1 receptor agonists are associated with reduced body weight, mediated direct indirect nervous system (CNS) effects. Objective We investigated the separate combined effects of dapagliflozin exenatide...
Executive functioning (EF) is a higher order cognitive process that thought to depend on network organization facilitating integration across subnetworks, in the context of which central role fronto-parietal (FPN) has been described imaging and neurophysiological modalities. However, potentially complementary unimodal information relevance FPN for EF not yet integrated. We employ multilayer framework allow different modalities into one 'network networks.' used diffusion MRI, resting-state...
Stimulants are the main pharmacological treatment for patients with attention-deficit/hyperactivity disorder (ADHD). Their current prescription rates rising, both in children, adolescents and adults. Related to impulse control phenotype, preclinical clinical studies have demonstrated lower γ-amino butyric acid (GABA) levels prefrontal brain regions ADHD. Whereas stimulant increases GABA levels, suggested that effects may be age-dependent. As long-term consequences of use ADHD children so far...
Abstract Background Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) different effects on dopaminergic serotonergic system in the developing brain compared to developed brain. The of Psychotropic drugs On Developing (ePOD) study is a combination approaches determine whether there are related findings humans. Methods/Design were carried out investigate age-related psychotropic validate new neuroimaging techniques. In addition, we set up two double-blind placebo...