A5014123749- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Neonatal and fetal brain pathology
- Neuroendocrine regulation and behavior
- Treatment of Major Depression
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Suicide and Self-Harm Studies
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Family Dynamics and Relationships
- Traumatic Brain Injury Research
- Attachment and Relationship Dynamics
- Political Philosophy and Ethics
- LGBTQ Health, Identity, and Policy
- Maternal Mental Health During Pregnancy and Postpartum
- Early Childhood Education and Development
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological and metabolic disorders
University of Pittsburgh
2020-2025
Center for the Neural Basis of Cognition
2021-2024
Center for Neurosciences
2023-2024
Stanford University
2019
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
Developmental trajectories during the transition from adolescence to adulthood contribute establishment of stable, adult forms operation. Understanding neural mechanisms underlying this is crucial for identifying variability in normal development and onset psychiatric disorders, which typically emerge time. Habitual behaviors can serve as a model understanding brain stabilization behavior, while also conferring risk psychopathologies. Dopaminergic (DA) processes basal ganglia are thought...
There is mounting evidence that ADHD associated with alterations in brain structure and function but it remains unclear how these indices relate to each other correspond symptom trajectories from childhood into adulthood. In this study, we aim determine whether the coupling between structural connectivity (SC) functional (FC) linked symptoms a longitudinal sample of individuals diagnosed followed Specifically, will test differences SC-FC within network neural regions centered on two specific...
There is mounting evidence that ADHD associated with alterations in brain structure and function but it remains unclear how these indices relate to each other correspond symptom trajectories from childhood into adulthood. In this study, we aim determine whether the coupling between structural connectivity (SC) functional (FC) linked symptoms a longitudinal sample of individuals diagnosed followed Specifically, will test differences SC-FC within network neural regions centered on two specific...
Animal models of stress and related conditions, including depression, have shown that elevated peripheral levels inflammatory cytokines downstream consequences on glutamate (Glu) in the brain. Although studies human adults with depression reported evidence higher inflammation but lower Glu anterior cingulate cortex (ACC), extent to which contributes glutamatergic abnormalities adolescents is not well-understood. It also unclear whether antioxidants, such as ascorbate (Asc), may buffer...
Adolescence is defined by puberty and represents a period characterized neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have age-related changes, the extent to which influences of networks less known. Here, we combine two longitudinal datasets characterize role in development resting-state functional connectivity (rsFC) its relationship inhibitory control 106 10–18-year-olds. Beyond age effects, found that was related decreases...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development improving early intervention prevention. The ENIGMA Suicidal Thoughts Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites examine morphology STBs youth. We performed analyses three separate stages, samples ranging from most least homogeneous terms of suicide assessment instrument mental disorder. First, a sample...
Early adolescence, with the onset of puberty, is an important period when sex differences in anxiety emerge, girls reporting significantly higher symptoms than boys. This study examined role puberty on fronto-amygdala functional connectivity and risk 70 (age 11-13) who completed a resting state fMRI scan, self-report measures pubertal status, provided basal testosterone levels (64 girls). Resting data were preprocessed using fMRIPrep indices extracted from ventromedial prefrontal cortex...
Abstract Infancy is marked by rapid neural and emotional development. The relation between brain function emotion in infancy, however, not well understood. Methods for measuring predominantly rely on the BOLD signal; interpretation of signal infancy challenging because neuronal‐hemodynamic immature. Regional cerebral blood flow (rCBF) provides a context infant can yield insight into developmental maturity regions that may support affective behaviors. This study aims to elucidate relations...
This article provides an overview of the study protocol for Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls order examine inflammatory glutamatergic pathways that contribute recurrence depression adolescents. TIGER is first effects peripheral inflammation on neurodevelopmental trajectories by assessing changes cortical glutamate Here, describe...
Psychosocial stressors characterized by social threat, such as interpersonal loss and rejection, are associated with depression in adolescents. Few studies, however, have examined whether threat affects fronto-cingulate-limbic systems implicated adolescent depression.
In the perinatal period, reward and cognitive systems begin trajectories, influencing later psychiatric risk. The basal ganglia is important for processing but early development has not been fully characterized. To assess age-related development, we used a measure of physiology, specifically brain tissue iron, obtained from nT2* signal in resting-state functional magnetic resonance imaging (rsfMRI), associated with dopaminergic processing. We data Developing Human Connectome Project (n =...
Caregivers who are higher in dispositional empathy tend to have children with better developmental outcomes; however, few studies considered the role of child-directed (i.e., "parental") empathy, which may be relevant for caregiver-child relationship. We hypothesized that mothers' parental during their child's infancy will a stronger predictor social-emotional functioning as toddler than empathy. further explored whether and shared or distinct patterns neural activation social-cognitive...
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (n=5,356) provide a generalizable ML classification benchmark major depressive disorder (MDD). Using brain measures...
Major depressive disorder (MDD) is a complex psychiatric that affects the lives of hundreds millions individuals around globe. Even today, researchers debate if morphological alterations in brain are linked to MDD, likely due heterogeneity this disorder. The application deep learning tools neuroimaging data, capable capturing non-linear patterns, has potential provide diagnostic and predictive biomarkers for MDD. However, previous attempts demarcate MDD patients healthy controls (HC) based...
Abstract Adolescence is defined by puberty and represents a period characterized neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have age-related changes, the extent to which influences of networks less known. Here, we combine two longitudinal datasets characterize role in development resting-state functional connectivity (rsFC) its relationship inhibitory control 106 10-18-year-olds. Beyond age effects, found that was related...
Abstract Objective Identifying brain differences associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development generating effective approaches early intervention prevention. The ENIGMA Suicidal Thoughts Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites examine morphology STBs youth. Methods First, we examined associations among regional structure STBs, which were assessed six samples of youth mood...
Caregivers who are higher in dispositional empathy tend to have children with better developmental outcomes; however, few studies considered the role of child-directed (i.e., “parental”) empathy, which may be relevant for caregiver–child relationship. We hypothesized that mothers’ parental during their child’s infancy will a stronger predictor social-emotional functioning as toddler than empathy. further explored whether and shared or distinct patterns neural activation social-cognitive...