A5072251892- Mathematical Biology Tumor Growth
- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Single-cell and spatial transcriptomics
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Ethics and Social Impacts of AI
- Cell Image Analysis Techniques
- Statistical Methods and Inference
- Advancements in PLL and VCO Technologies
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- Photonic and Optical Devices
- Particle Detector Development and Performance
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Statistical Methods in Clinical Trials
- Social and Cultural Dynamics
- Wine Industry and Tourism
Memorial Sloan Kettering Cancer Center
2024
Southern Methodist University
2021-2024
The University of Texas Southwestern Medical Center
2024
The incidence and mortality of early onset colorectal cancer (EOCRC) is rising; outcomes appear to differ by race ethnicity. We aimed assess differences in mutational landscape gene expression EOCRC racial ethnic groups (non-Hispanic Asian, non-Hispanic Black, White, White Hispanic) using data from the American Association for Cancer Research Project GENIE (10.2) University Texas Southwestern, latter enriched Hispanic patients. All statistical tests were 2-sided. Of 1752 patients, Black...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
SUMMARY Quantitative assessment of multiplex immunofluorescence (mIF) data represents a powerful tool for immunotherapy biomarker discovery in melanoma and other solid tumors. In addition to providing detailed phenotypic information immune cells the tumor microenvironment, these datasets contain spatial that can reveal biologically relevant interactions among cell types. To assess quantitative mIF analysis as platform discovery, we used 12-plex panel characterize samples collected from 50...
Achieving effective synergy between radiotherapy and immunotherapy is critical for optimizing tumor control treatment outcomes. To explore the underlying mechanisms of this synergy, we have investigated a novel approach known as personalized ultra-fractionated stereotactic adaptive radiation therapy (PULSAR), which emphasizes impact timing on efficacy. However, precise mechanism remains unclear. Building insights from small animal PULSAR studies, developed mathematical framework consisting...
PULSAR (personalized ultrafractionated stereotactic adaptive radiotherapy) is a form of radiotherapy method where patient given large dose or pulse radiation couple weeks apart rather than daily small doses. The tumor response then monitored to determine when the subsequent should be given. Pre-clinical trials have shown better in mice that received immunotherapy along with pulses spaced 10 days apart. However, this was not case were 1 day Therefore, synergistic effect between and observed...
Recent progress in multiplexed tissue imaging is advancing the study of tumor microenvironments to enhance our understanding treatment response and disease progression. Cellular neighborhood analysis a popular computational approach for these complex image data. Despite its popularity, there are significant challenges, including high demands that limit feasibility large-scale applications lack principled strategy integrative across images. This absence hampers precise consistent...
Heavy metal ethnography and historiography has been extensively explored from a qualitative perspective. However, quantitative methods of analysis have not developed. We conduct Bayesian geographical heavy subgenres, investigating the relative prevalence each subgenre in nations (for 86 countries northern Europe West), overall popularity, according to selected countries. Data two different websites, MetalStorm Encyclopaedia Metallum, were harvested via web ‘scraping’ used for analysis....
Queer in AI is an organization that aims to combat the harms faced by queer researchers within AI. Several inclusion initiatives are outlined, including those centered on policy and financial aid.
We present the procedures and results of quality control tests for front-end optical link components in ATLAS Liquid Argon Calorimeter Phase-1 upgrade. The include a Vertical-Cavity Surface-Emitting Laser (VCSEL) driver ASIC LOCld, custom transmitter/transceiver modules MTx/MTRx, transmitter LOCx2. MTx, LOCx2 each contain two channels with same structure, while MTRx has channel receiver channel. Each is tested at 5.12 Gbps. A total 5341 LOCld chips, 3275 MTx modules, 797 3198 chips are...