A5059119647- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Cognitive Functions and Memory
- Neonatal and fetal brain pathology
- Psychosomatic Disorders and Their Treatments
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Advanced Chemical Sensor Technologies
- Psychology of Moral and Emotional Judgment
- Media Influence and Health
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Mental Health and Psychiatry
- Neuroscience and Music Perception
- Renal cell carcinoma treatment
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Neuroscience, Education and Cognitive Function
- Child Development and Digital Technology
- Film in Education and Therapy
National Institute of Mental Health
2024-2025
University College London
2018-2024
University of London
2022
Yale University
2021-2022
University of Pennsylvania
2020-2021
Institute of Cognitive Neuroscience and Psychology
2020
Saint-Gobain (United States)
2011
Introduction: Even though resting-state functional connectivity (rs-FC) is conceptualized asmeasuring ‘intrinsic connectivity’, in-scanner experiences undoubtedly influence rs-FC. Themajority of work on anxiety and rs-FC does not consider the subjective state participantduring magnetic resonance imaging (MRI) procedure. Heightened before an MRI(i.e., pre-scanning anxiety), common in diverse samples, may be uniquely associated withindividual differences brain activity. The current study...
Movie-watching fMRI has emerged as a theoretically viable platform for studying neurobiological substrates of affective states and emotional disorders such pathological anxiety. However, using anxiety-inducing movie clips to probe relevant impacted by psychopathology could risk exacerbating in-scanner movement, decreasing signal quality/quantity thus statistical power. This be especially problematic in target populations children who typically move more the scanner. Consequently, we...
Humans, like other animals, have an excellent sense of smell that can serve social communication. Although ample research has shown body odours convey transient emotions fear, these studies exclusively treated as categorical , neglecting the question whether emotion quantity be expressed chemically. Using a unique combination methods and techniques, we explored dose–response function: Can experienced fear intensity encoded in sweat? Specifically, experience was quantified using multivariate...
Abstract A well‐documented amygdala‐dorsomedial prefrontal circuit is theorized to promote attention threat (“threat vigilance”). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features the environment (e.g., through threat‐of‐shock movie‐watching). In present study, we predicted that—for those scoring high self‐reported anxiety behavioral measure vigilance—this circuitry chronically...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Setting external reminders provides a convenient way to reduce cognitive demand and ensure accurate retrieval of information for prospective tasks. Recent experimental evidence has demonstrated that the decision offload resources is guided by metacognitive belief, is, individuals’ confidence in their unaided ability. Other work also suggested relationship between belief trait anxiety. In present study ( N = 300), we bridged these two areas investigating whether anxiety correlated with...
Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) entrain its responsiveness. To date, this has been established in tightly controlled paradigms (predominantly using static face perception tasks) but not extended to more naturalistic settings....
It is well accepted that emotional intensity scales with stimulus strength. Here, we used physiological and neuroimaging techniques to ask whether human body odor—which can convey salient social information—also induces dose-dependent effects on behavior, physiology, neural responses. To test this, first collected sweat from 36 males classified as low-, medium-, high-fear responders. Next, in a double-blind within-subjects functional-MRI design, 31 women were exposed three doses of...
Abstract During states of anxiety, fundamental threat circuitry in the brain can increase heart rate via alterations autonomic balance (increased sympathetic activity and parasympathetic withdrawal) may serve to promote interoceptive integration awareness cardiac signals. Moreover, evidence indicates pathological anxiety could be associated with increased communication between heart. Yet, this phenomenon remains not well understood. For instance, studies area have been conducted within...
Heart rate and heart variability have enabled insight into a myriad of psychophysiological phenomena. There is now an influx research attempting using these metrics within both laboratory settings (typically derived through electrocardiography or pulse oximetry) ecologically-rich contexts ( via wearable photoplethysmography, i.e. , smartwatches). However, signals can be prone to artifacts low signal noise ratio, which traditionally are detected removed visual inspection. Here, we developed...
A well-characterized amygdala-dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved.Using an open functional magnetic resonance imaging dataset (Cambridge Centre Ageing Neuroscience; n = 630), we sought investigate whether anxiety correlates with dynamic connectivity between the amygdala and dorsomedial cortex movie watching.Using intersubject...
Abstract Anxiety involves the anticipation of aversive outcomes and can impair neurocognitive processes, such as ability to recall faces encoded during anxious state. It is important precisely delineate determine replicability these effects using causal state anxiety inductions in general population. This study therefore aimed replicate prior research on distinct impacts threat-of-shock-induced encoding recognition stage emotional face processing, a large asymptomatic sample ( n = 92). We...
Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of several conditions including anxiety disorders, but basic neurobiology function remains unclear. The amygdala and prefrontal cortex strongly innervated by serotonergic projections have been suggested to play an important role in expression. However, behaviour SSRI-mediated neurobiological changes remain incompletely understood.
Anxiety alters how we perceive the world and can alter aspects of cognitive performance. Prominent theories anxiety suggest that effect on cognition is due to anxious thoughts "overloading" limited resources, competing with other processes. If this so, then a load manipulation should impact performance task in same way as induced anxiety. Thus, examined time perception have previously shown be reliably impacted by In contrast our prediction, across 3 studies found was insensitive...
There are known associations between the presence of experimentally-presented threats and peripheral physiological responses, such as a heart rate, which holds implications for understanding pathological levels anxiety. Moving away from traditional task-based paradigms, we investigated whether subjective experience (i.e., continuous state anxiety ratings) rate were associated with individual variations (n=133) in trait symptomatology (items on hospital depression scale) during an anxiogenic...
Movie-watching fMRI has emerged as a theoretically viable platform for studying neurobiological substrates of affective states and emotional disorders such pathological anxiety. However, using anxiety-inducing movie clips to probe relevant impacted by psychopathology could risk exacerbating in-scanner movement, decreasing signal quality/quantity thus statistical power. This be especially problematic in target populations children who typically move more the scanner. Consequently, we...
Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda clinical scientists: understanding the pathophysiology of altered subjective experiences disorders. For brain imaging, movie-watching approaches help clinicians realize this due movies' relative strength...
Movie-watching fMRI has emerged as a theoretically viable platform for studying neurobiological substrates of affective states and emotional disorders such pathological anxiety. However, using anxiety-inducing movie clips to probe relevant impacted by psychopathology could risk exacerbating in-scanner movement, decreasing signal quality/quantity thus statistical power. This be especially problematic in target populations children who typically move more the scanner. Consequently, we...
Heart rate and heart variability have enabled insight into a myriad of psychophysiological phenomena. There is now an influx research attempting using these metrics within both laboratory settings (typically derived through electrocardiography or pulse oximetry) ecologically-rich contexts (via wearable photoplethysmography, i.e. smartwatches). However, signals can be prone to artifacts low signal noise ratio, which traditionally are detected removed visual inspection. Here, we developed...
A well characterized amygdala-prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, the engagement of this circuitry within relatively naturalistic paradigms remains unresolved. Using an open fMRI dataset (CamCAN; N=630), we sought investigate whether anxiety correlates with dynamic connectivity between amygdala and dorsomedial prefrontal cortex movie-watching. inter-subject representational similarity approach, saw no effect when comparing pairwise...
A well documented amygdala-dorsomedial prefrontal circuit is theorized to promote attention threat (‘threat vigilance’). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features the environment (e.g. through threat-of-shock movie-watching). In present study, we predicted that—for those scoring high self-reported anxiety behavioral measure vigilance—this circuitry chronically engaged, even...
Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) entrain its responsiveness. To date, this has been established in tightly controlled paradigms (predominantly using static face perception tasks) but not extended to more naturalistic settings....