A5014615348- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
- Neuroendocrine regulation and behavior
- stochastic dynamics and bifurcation
- Adaptive optics and wavefront sensing
- Digital Mental Health Interventions
- Protein Structure and Dynamics
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Williams Syndrome Research
- Distributed systems and fault tolerance
- Glycogen Storage Diseases and Myoclonus
- Personality Traits and Psychology
- Radiomics and Machine Learning in Medical Imaging
- Neural dynamics and brain function
- Lysosomal Storage Disorders Research
- Behavioral Health and Interventions
- Obsessive-Compulsive Spectrum Disorders
- Nuclear reactor physics and engineering
- Identity, Memory, and Therapy
- Astrophysical Phenomena and Observations
University of Maryland, College Park
2021-2025
National Institute of Mental Health
2018-2021
United States Department of Health and Human Services
2021
National Institutes of Health
2020
Northwestern University
2014-2018
Fear and anxiety play a central role in the lives of humans other animals, there is considerable interest clarifying their nature, identifying biological underpinnings, determining consequences for health disease. Although important strides have been made over past half-century, it has become clear that our understanding remains far from complete. Here we provide roundtable discussion on nature bases fear- anxiety-related states, traits, psychiatric disorders. The discussants include...
Temporal dynamics play a central role in models of emotion: "fear" is widely conceptualized as phasic response to certain-and-imminent danger, whereas "anxiety" sustained uncertain-or-distal harm. Yet the underlying neurobiology remains contentious. Leveraging translationally relevant fMRI paradigm and theory-driven modeling approach 220 adult humans, we demonstrate that certain- uncertain-threat anticipation recruit shared circuit encompasses extended amygdala (EAc), periaqueductal gray,...
Negative affect is a fundamental dimension of human emotion. When extreme, it contributes to variety adverse outcomes, from physical and mental illness divorce premature death. Mechanistic work in animals neuroimaging research humans monkeys have begun reveal the broad contours neural circuits governing negative affect, but relevance these discoveries everyday distress remains incompletely understood. Here, we used combination approaches—including assays threat anticipation emotional-face...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Mutations in GBA1, the gene mutated Gaucher disease, are a common genetic risk factor for Parkinson although penetrance is low. We performed [18 F]-fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) 98 controls looking early indications dopamine loss using voxelwise analyses to identify group differences striatal uptake (Ki ). Forty-eight subjects were followed longitudinally. Cross-sectional longitudinal...
Neuroticism/negative emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, well-being. Elevated N/NE is associated panoply adverse outcomes, from reduced socioeconomic attainment psychiatric illness. Animal research suggests that reflects heightened reactivity uncertain threat in the bed nucleus stria terminalis (BST) central amygdala (Ce), but relevance these...
ABSTRACT Negative affect is a fundamental dimension of human emotion. When extreme, it contributes to variety adverse outcomes—from physical and mental illness divorce premature death. Mechanistic work in animals neuroimaging research humans monkeys has begun reveal the broad contours neural circuits governing negative affect, but relevance these discoveries everyday distress remains incompletely understood. Here we used combination approaches— including assays threat anticipation emotional...
This report begins with a review of the basic concept deformable X-ray optics, and need for this approach future astronomy missions that have ~1" resolution. We then on our advances made using magnetic smart materials (MSMs) to adjust shape thin (~100-200 µm thickness) electroformed replicated optics or glass optics. show we can well model deflections in 5 mm x 20 pieces provide preliminary evidence will work involves imposing field hard substrate (NiCo) maintain change mirror shape.
We present our idea to correct the surface profile of X-ray telescope mirrors by employing a spatially distributed variable stress coating. Future missions require light weight optics with an angular resolution ≤. 1" . However, typical desired thickness mirror shell is ≤ 0.4mm, and date such thin shelled that have been fabricated cannot meet required figure accuracy. Therefore most common approach modify initially produced shell. In this paper, we describe one approach. Our uses DC magnetron...
Neuroticism/Negative Emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, wellbeing. Elevated N/NE is associated panoply adverse outcomes, from reduced socioeconomic attainment psychiatric illness. Animal research suggests that reflects heightened reactivity uncertain threat in the bed nucleus stria terminalis (BST) central amygdala (Ce), but relevance these...
Elevated levels of Neuroticism/Negative Emotionality (N/NE) and, less consistently, lower Extraversion/Positive (E/PE) confer risk for pathological depression and anxiety. To date, most prospective-longitudinal research has narrowly focused on traditional diagnostic categories, creating uncertainty about the precise nature these prospective associations. Adopting an explicitly hierarchical-dimensional approach, we examined association between baseline variation in personality longitudinal...
Abstract Among individuals with psychotic disorders, paranoid ideation is common and associated increased impairment, decreased quality of life, a more pessimistic prognosis. Although accumulating research indicates negative affect key precipitant ideation, the possible protective role positive has not been examined. Further, despite interpersonal nature there are limited inconsistent findings regarding how social context, perceptions, motivation influence in real-world contexts. In this...
Temporal dynamics play a central role in models of emotion: "fear" is widely conceptualized as phasic response to certain-and-imminent danger, whereas "anxiety" sustained uncertain-or-distal harm. Yet the underlying neurobiology remains contentious. Leveraging translationally relevant fMRI paradigm and theory-driven modeling approach, we demonstrate that certain- uncertain-threat anticipation recruit shared circuit encompasses extended amygdala (EAc), periaqueductal gray, midcingulate,...