A5079176899- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Electroconvulsive Therapy Studies
- Electrolyte and hormonal disorders
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Treatment of Major Depression
- Maternal Mental Health During Pregnancy and Postpartum
- Muscle metabolism and nutrition
- Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Exercise and Physiological Responses
Cleveland Clinic
2025
National Institute of Mental Health
2009-2022
National Institutes of Health
2003-2022
National Institute of Mental Health
2016
Brigham Young University
2014
United States Department of Health and Human Services
2013
Harvard University
2012
University of Maryland, College Park
2012
Stanford University
1996-2012
University of California, Davis
2011
Objective: Behavioral inhibition is an early childhood temperament recently associated with altered striatal response in adolescence to incentives of increasing magnitudes. Since behavioral also risk for adolescent social phobia, a similar pattern activation may manifest phobia. The present study compares function healthy adolescents, adolescents and generalized anxiety disorder. Method: Blood-oxygen-level-dependent signal regions was examined 58 medication-free adolescents—14 18 disorder...
Functional imaging data were acquired during performance of a reward-contingency task in unique cohort adolescents (ages 14-18 years) who characterized since infancy on measures temperamental behavioral inhibition. Neural activation was examined striatal structures (nucleus accumbens, putamen, caudate) with known role facilitating response to salient reward-related cues. Adolescents history inhibition, relative noninhibited adolescents, showed increased the nucleus accumbens when they...
Abstract Behavioral inhibition, a temperament identifiable in infancy, is associated with heightened withdrawal from social encounters. Prior studies raise particular interest the striatum, which responds uniquely to monetary gains behaviorally inhibited children followed into adolescence. Although behavioral manifestations of inhibition are expressed primarily domain, it remains unclear whether observed striatal alterations incentives also extend contexts. In current study, imaging data...
The striatum codes motivated behavior. Delineating age-related differences within striatal circuitry can provide insights into neural mechanisms underlying ontogenic behavioral changes and vulnerabilities to mental disorders. To this end, a dual ventral/dorsal model of function was examined using resting state intrinsic functional connectivity (iFC) imaging in 106 healthy individuals, ages 9-44. Broadly, the dorsal (DS) is connected prefrontal parietal cortices contributes cognitive...
This study examines the effects of puberty and sex on intrinsic functional connectivity (iFC) brain networks, with a focus default-mode network (DMN). Consistently implicated in depressive disorders, DMN's function may interact development these whose onsets peak adolescence, which show strong disproportionality (females > males). The main question concerns how DMN evolves as sex. These are expected to involve within- between-network iFC, particularly, salience central-executive consistent...
Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging children adults (5–90...
For more than a century, mesial cerebral structures have been candidate substrates for the mediation of emotional experience. Although limbic were originally conceived as forming midline ring, emerging evidence suggests that processes may be related closely to anterior paralimbic (anterior and nearby cortical) regions posterior regions. In addition, basal ganglia-thalamocortical circuits various proposed, including one involving thought mediate emotion. Recent brain imaging studies advanced...