Gisele Gus Manfro

ORCID: 0000-0002-0109-7591
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About
Contact & Profiles
Research Areas
  • Child and Adolescent Psychosocial and Emotional Development
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Youth, Drugs, and Violence
  • Mental Health Research Topics
  • Psychology and Mental Health
  • Attention Deficit Hyperactivity Disorder
  • Occupational Health and Burnout
  • Maternal Mental Health During Pregnancy and Postpartum
  • Stress Responses and Cortisol
  • Obsessive-Compulsive Spectrum Disorders
  • Birth, Development, and Health
  • Eating Disorders and Behaviors
  • Child Abuse and Trauma
  • Child Nutrition and Feeding Issues
  • Functional Brain Connectivity Studies
  • Bullying, Victimization, and Aggression
  • Mental Health Treatment and Access
  • Perfectionism, Procrastination, Anxiety Studies
  • Early Childhood Education and Development
  • Tryptophan and brain disorders
  • COVID-19 and Mental Health
  • Attachment and Relationship Dynamics
  • Psychosomatic Disorders and Their Treatments
  • Autism Spectrum Disorder Research
  • Obesity, Physical Activity, Diet

Universidade Federal do Rio Grande do Sul
2016-2025

Hospital de Clínicas de Porto Alegre
2016-2025

National Council for Scientific and Technological Development
2014-2024

Universidade Federal do Rio Grande
2021

Universidade Federal de São Paulo
2018

Instituto Nacional de Psiquiatria do Desenvolvimento para Crianças e Adolescentes
2010-2017

University of Rio Grande and Rio Grande Community College
2013-2015

Support group for adolescents and children with cancer
2011-2014

Harvard University
2000-2003

Massachusetts General Hospital
1996-2000

A ansiedade e o medo passam a ser reconhecidos como pa-tologicos quando sao exagerados, desproporcionais em rela-cao ao est imulo, ou qualitativamente diversos do que se obser-va norma naquela faixa etaria interferem com quali-dade de vida, conforto emocional desempenho di ario doindividuo.

10.1590/s1516-44462000000600006 article PT cc-by-nc Brazilian Journal of Psychiatry 2000-12-01

High rates of comorbidities and poor validity disorder diagnostic criteria for mental disorders hamper advances in health research. Recent work has suggested the utility continuous cross-cutting dimensions, including general psychopathology specific factors externalizing internalizing (e.g., distress fear) syndromes. The current study evaluated reliability competing structural models examined external best fitting model on basis family risk child global executive function (EF). A community...

10.1037/abn0000205 article EN Journal of Abnormal Psychology 2016-10-17

This study examined the psychometric properties of Brazilian-Portuguese version Generalized Anxiety Disorder GAD-7 questionnaire in a community sample (n = 206) Brazilian adults.The was 41% female, with mean age 21.10 (SD 4.49), 75.6% from colleges/universities.Results confi rmatory factor analysis provided support to original unidimensional model context.Analyses Variance (ANOVA) showed that scores were signifi cantly different between males and females, females scoring higher than...

10.9788/tp2016.1-25 article EN Temas em Psicologia 2016-01-01

The objective of this study is to present the rationale, methods, design and preliminary results from High Risk Cohort Study for Development Childhood Psychiatric Disorders. We describe sample selection components each phases study, its instruments, tasks procedures. Preliminary are limited baseline phase encompass: (i) efficacy oversampling procedure used increase frequency both child family psychopathology; (ii) interrater reliability (iii) role differential participation rate. A total...

10.1002/mpr.1459 article EN International Journal of Methods in Psychiatric Research 2014-12-03

The Childhood Trauma Questionnaire (CTQ) is internationally accepted as a key tool for the assessment of childhood abuse and neglect experiences. However, there are relative few psychometric studies available some authors have proposed two different factor solutions. We examined dimensional structure internal consistency Brazilian version CTQ. A total 1,925 participants from eight clinical non-clinical samples including adolescents, adults elders were considered in this study. First, we...

10.1371/journal.pone.0087118 article EN cc-by PLoS ONE 2014-01-27

Preliminary research implicates threat-related attention biases in paediatric anxiety disorders. However, major questions exist concerning diagnostic specificity, effects of symptom-severity levels, and threat-stimulus exposure durations paradigms. This study examines these issues a large, community school-based sample. Method A total 2046 children (ages 6-12 years) were assessed using the Development Well Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL) dot-probe tasks....

10.1017/s0033291712001651 article EN Psychological Medicine 2012-07-31

Abstract Exposure to childhood adversity has been consistently associated with poor developmental outcomes, but it is unclear whether these associations vary across different forms of adversity. We examined cross‐sectional and longitudinal between threat deprivation cognition, emotional processing, psychopathology in a middle‐income country. The sample consisted 2511 children adolescents (6–17 years old) from the Brazilian High‐Risk Cohort for Mental Conditions. Parent reports on were used...

10.1111/desc.13267 article EN Developmental Science 2022-04-13

Abstract Extracellular vesicles (EVs) are present in numerous peripheral bodily fluids and function critical biological processes, including cell-to-cell communication. Most relevant to the study, EVs contain microRNAs (miRNAs), initial evidence from field indicates that miRNAs detected circulating have been previously associated with mental health disorders. Here, we conducted an exploratory longitudinal cross-sectional analysis of miRNA expression serum adolescent participants. We analyzed...

10.1038/s41398-023-02326-4 article EN cc-by Translational Psychiatry 2023-02-06

The present study was designed to verify the efficacy of cognitive-behavioral group therapy (CBGT) in reducing obsessive-compulsive symptoms and intensity overvalued ideas, as well improving patient's quality life.Forty-seven patients meeting DSM-IV criteria for disorder (OCD) were randomly assigned either 12 weekly CBGT sessions or a waiting list (control group). Treated followed three months.There significant reduction Yale-Brown Obsessive-Compulsive Scale (p < 0.001), National Institute...

10.1159/000070785 article EN Psychotherapy and Psychosomatics 2003-01-01

The serotonin selective reuptake inhibitors are increasingly being used for the treatment of panic disorder. We examined efficacy and safety inhibitor sertraline hydrochloride in patients with disorder.One hundred seventy-six nondepressed outpatients disorder, or without agoraphobia, from 10 sites followed identical protocols that a flexible-dose design. After 2 weeks single-blind placebo, were randomly assigned to double-blind, either (50-200 mg/d) placebo.Sertraline-treated exhibited...

10.1001/archpsyc.55.11.1010 article EN Archives of General Psychiatry 1998-11-01

Article Abstract Background: Cognitive-behavioral group therapy (CBGT) and serotonin reuptake inhibitors have proven efficacy in reducing symptoms of obsessive-compulsive disorder (OCD). There is no consensus about which these forms treatment more effective. This study was conducted to evaluate the CBGT as compared that sertraline OCD symptoms. Method: Fifty-six outpatients with an diagnosis, according DSM-IV criteria, participated randomized clinical trial: 28 took 100 mg/day underwent for...

10.4088/jcp.v67n0717 article EN The Journal of Clinical Psychiatry 2006-07-15

Adverse early-life environment is associated with anxiety-like behaviors and disorders. Brain-derived neurotrophic factor (BDNF) sensitive to this could be a marker of underlying brain changes. We aimed at evaluating the development in rat model early adversity, as well possible association BDNF levels. Similar associations were investigated sample adolescent humans. For study, Wistar litters divided into: stress (ELS, limited access nesting material) control groups. Maternal behavior was...

10.1038/tp.2012.126 article EN cc-by Translational Psychiatry 2012-11-20

Background Both inhibitory-based executive functioning (IB-EF) and basic information processing (BIP) deficits are found in clinic-referred attention deficit hyperactivity disorder (ADHD) samples. However, it remains to be determined whether: (1) such occur non-referred samples of ADHD; (2) they specific (3) the co-morbidity between ADHD oppositional defiant disorder/conduct (ODD/CD) has additive or interactive effects; (4) IB-EF primary due BIP deficits. Method We assessed 704 subjects (age...

10.1017/s0033291713000639 article EN Psychological Medicine 2013-04-08

Objective: Alzheimer’s disease is a heritable neurodegenerative disorder in which early-life precursors may manifest cognition and brain structure. The authors evaluate this possibility by examining, youths, associations among polygenic risk score for disease, cognitive abilities, hippocampal volume. Method: Participants were children 6–14 years of age two Brazilian cities, constituting the discovery (N=364) replication samples (N=352). As an additional replication, data from Canadian sample...

10.1176/appi.ajp.2017.17050529 article EN American Journal of Psychiatry 2018-03-02

Background. Taxometric and behavioral genetic studies suggest that attention deficit hyperactivity disorder (ADHD) is best modeled as a dimension rather than category. We extended these analyses by testing for the existence of putative ADHD-related deficits in basic information processing (BIP) inhibitory-based executive function (IB-EF) individuals subclinical full clinical ranges. Consistent with dimensional model, we predicted would be expressed across spectrum, degree linearly related to...

10.1017/s0033291714000919 article EN Psychological Medicine 2014-04-25
Anita Harrewijn Elise M. Cardinale Nynke A. Groenewold Janna Marie Bas‐Hoogendam Moji Aghajani and 89 more Kevin Hilbert Narcı́s Cardoner Daniel Porta‐Casteràs Savannah N. Gosnell Ramiro Salas Andrea Parolin Jackowski Pedro Mário Pan Giovanni Abrahão Salum Karina S. Blair James Blair Mira Z. Hammoud Mohammed R. Milad Katie L. Burkhouse K. Luan Phan Heidi K. Schroeder Jeffrey R. Strawn Katja Beesdo‐Baum Neda Jahanshad Sophia I. Thomopoulos Randy L. Buckner Jared A. Nielsen Jordan W. Smoller Jair C. Soares Benson Mwangi Mon‐Ju Wu Giovana Zunta‐Soares Michal Assaf Gretchen J. Diefenbach Paolo Brambilla Eleonora Maggioni David Hofmann Thomas Straube Carmen Andreescu Rachel Berta Erica Tamburo Rebecca B. Price Gisele Gus Manfro Federica Agosta Elisa Canu Camilla Cividini Massimo Filippi Milutin Kostić Ana Munjiza Bianca A. V. Alberton Brenda E. Benson Gabrielle F. Freitag Courtney A. Filippi Andrea L. Gold Ellen Leibenluft Grace Ringlein Kathryn E. Werwath Hannah Zwiebel André Zugman Hans J. Grabe Sandra Van der Auwera Katharina Wittfeld Henry Völzke Robin Bülow Nicholas L. Balderston Monique Ernst Christian Grillon Lilianne R. Mujica‐Parodi Helena van Nieuwenhuizen Hugo Critchley Elena Makovac Matteo Mancini Frances Meeten Cristina Ottaviani Tali M. Ball Gregory A. Fonzo Martin P. Paulus Murray B. Stein Raquel E. Gur Ruben C. Gur Antonia N. Kaczkurkin Bart Larsen Theodore D. Satterthwaite Jennifer C. Harper Michael J. Myers Michael T. Perino Chad M. Sylvester Qiongru Yu Ulrike Lueken Dick J. Veltman Paul M. Thompson Dan J. Stein Nic J.A. van der Wee Anderson M. Winkler Daniel S. Pine

Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging children adults (5–90...

10.1038/s41398-021-01622-1 article EN cc-by Translational Psychiatry 2021-10-01
Willem B. Bruin Paul Zhutovsky Guido van Wingen Janna Marie Bas‐Hoogendam Nynke A. Groenewold and 95 more Kevin Hilbert Anderson M. Winkler André Zugman Federica Agosta Fredrik Åhs Carmen Andreescu Chase Antonacci Takeshi Asami Michal Assaf Jacques P. Barber Jochen Bauer Shreya Y. Bavdekar Katja Beesdo‐Baum Francesco Benedetti Rachel Bernstein Johannes Björkstrand James Blair Karina S. Blair Laura Blanco‐Hinojo Joscha Böhnlein Paolo Brambilla Rodrigo A. Bressan Fabian Breuer Marta Cano Elisa Canu Elise M. Cardinale Narcı́s Cardoner Camilla Cividini Henk Cremers Udo Dannlowski Gretchen J. Diefenbach Katharina Domschke Alex Doruyter Thomas Dresler Angelika Erhardt Massimo Filippi Gregory A. Fonzo Gabrielle F. Freitag Tomas Furmark Tian Ge Andrew J. Gerber Savannah N. Gosnell Hans J. Grabe Dominik Grotegerd Ruben C. Gur Raquel E. Gur Alfons O. Hamm Laura K. M. Han Jennifer C. Harper Anita Harrewijn Alexandre Heeren David Hofmann Andrea Parolin Jackowski Neda Jahanshad Laura Jett Antonia N. Kaczkurkin Parmis Khosravi Ellen Kingsley Tilo Kircher Milutin Kostić Bart Larsen Sang‐Hyuk Lee Elisabeth J. Leehr Ellen Leibenluft Christine Löchner Su Lui Eleonora Maggioni Gisele Gus Manfro Kristoffer Månsson Claire E. Marino Frances Meeten Barbara Milrod Ana Munjiza Benson Mwangi Michael J. Myers Susanne Neufang Jared A. Nielsen Patricia Ohrmann Cristina Ottaviani Martin P. Paulus Michael T. Perino K. Luan Phan Sara Poletti Daniel Porta‐Casteràs Jesùs Pujol Andrea Reinecke Grace Ringlein Pavel Rjabtsenkov Karin Roelofs Ramiro Salas Giovanni Abrahão Salum Theodore D. Satterthwaite Elisabeth Schrammen Lisa Sindermann Jordan W. Smoller

10.1038/s44220-023-00173-2 article EN Nature Mental Health 2024-01-10

In this study we assessed the quality of life patients with panic disorder, particular attention to influence anxiety and depression comorbidity on life. Findings were compared established general population norms as well for chronic medical conditions major depression. The Medical Outcomes Study Short-Form Health Survey (SF-36) was administered disorder entering clinical trials or treatment in an outpatient disorders program. Subjects 73 consecutive a primary diagnosis without current...

10.1097/00005053-199907000-00006 article EN The Journal of Nervous and Mental Disease 1999-07-01
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