A5024166035- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- Musculoskeletal pain and rehabilitation
- Healthcare Education and Workforce Issues
- Diverse Approaches in Healthcare and Education Studies
- Face Recognition and Perception
- Spatial Neglect and Hemispheric Dysfunction
- Cerebrospinal fluid and hydrocephalus
- Action Observation and Synchronization
- Thyroid and Parathyroid Surgery
- Airway Management and Intubation Techniques
- Educational Games and Gamification
- Eosinophilic Esophagitis
- Child Therapy and Development
- Neurotransmitter Receptor Influence on Behavior
- Blind Source Separation Techniques
- Ergonomics and Musculoskeletal Disorders
University of California, Davis
2024
Neurological Surgery
2024
Stanford University
2018-2024
Palo Alto University
2019
Harvard University Press
2018
University of Rochester
2018
University of Rochester Medical Center
2016-2017
Center for Pain and the Brain
2014
Harvard University
2012
Athinoula A. Martinos Center for Biomedical Imaging
2012
The striatum is connected to the cerebral cortex through multiple anatomical loops that process sensory, limbic, and heteromodal information. Tract-tracing studies in monkey reveal these corticostriatal connections form stereotyped patterns striatum. Here organization of was explored human with resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered nonlinear deformation combination surface-based alignment cortex. fcMRI maps derived seed regions placed...
Speech brain-computer interfaces (BCIs) have the potential to restore rapid communication people with paralysis by decoding neural activity evoked attempted speech into text
BackgroundBrain–computer interfaces can enable communication for people with paralysis by transforming cortical activity associated attempted speech into text on a computer screen. Communication brain–computer has been restricted extensive training requirements and limited accuracy.MethodsA 45-year-old man amyotrophic lateral sclerosis (ALS) tetraparesis severe dysarthria underwent surgical implantation of four microelectrode arrays his left ventral precentral gyrus 5 years after the onset...
The human brain is comprised of a complex web functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular molecular properties. Here, using primate transcriptional atlases, we demonstrate spatial patterns gene expression show strong correspondence limbic somato/motor cortico-striatal networks. Network-associated consistent...
Abstract Speech brain-computer interfaces (BCIs) have the potential to restore rapid communication people with paralysis by decoding neural activity evoked attempted speaking movements into text 1,2 or sound 3,4 . Early demonstrations, while promising, not yet achieved accuracies high enough for of unconstrainted sentences from a large vocabulary 1–7 Here, we demonstrate first speech-to-text BCI that records spiking intracortical microelectrode arrays. Enabled these high-resolution...
The canonical striatal map, based predominantly on frontal corticostriatal projections, divides the striatum into ventromedial-limbic, central-association, and dorsolateral-motor territories. While this has been a useful heuristic, recent studies indicate that more complex topography when considering converging nonfrontal inputs from distributed cortical networks. ventral (VS) in particular is often ascribed "limbic" role, but it receives diverse information, including motivation emotion...
The thalamus is a central integration structure in the brain, receiving and distributing information among cerebral cortex, subcortical structures, peripheral nervous system. Prior studies clearly show that atrophies cognitively unimpaired aging. However, comprised of multiple nuclei involved wide range functions, age-related atrophy individual thalamic remains unknown. Using recently developed automated method identifying (3T or 7T MRI with white-matter-nulled MPRAGE contrast THOMAS...
Patient lesion and neuroimaging studies have identified a rostral-to-caudal functional gradient in the lateral frontal cortex (LFC) corresponding to higher-order (complex or abstract) lower-order (simple concrete) cognitive control. At same time, monkey anatomical human connectivity show that regions are reciprocally connected with parietal temporal regions, forming parallel distributed association networks. Here, we investigated link between of LFC observed during control tasks parallel,...
Abstract Magnetic resonance‐guided focused ultrasound (MRgFUS) ablation of the ventral intermediate (Vim) thalamic nucleus is an incisionless treatment for essential tremor (ET). The standard initial targeting method uses approximate, atlas‐based stereotactic approach. We developed a new patient‐specific to identify individual's Vim and optimal MRgFUS target region therein suppression tremor. In this retrospective study 14 ET patients treated with MRgFUS, we investigated ability WMnMPRAGE,...
Circuit-based mechanisms mediating the development and execution of habitual behaviors involve complex cortical-striatal interactions that have been investigated in animal models more recently humans. However, how human brain circuits implicated habit formation may be perturbed psychiatric disorders remains unclear. First, we identified locations sensorimotor putamen associative caudate using probabilistic tractography from Human Connectome Project data. We found multivariate connectivity...
Brain-computer interfaces can enable rapid, intuitive communication for people with paralysis by transforming the cortical activity associated attempted speech into text on a computer screen. Despite recent advances, brain-computer has been restricted extensive training data requirements and inaccurate word output. A man in his 40's ALS tetraparesis severe dysarthria (ALSFRS-R = 23) was enrolled BrainGate2 clinical trial. He underwent surgical implantation of four microelectrode arrays left...
Summary Understanding how the body is represented in motor cortex key to understanding brain controls movement. The precentral gyrus (PCG) has long been thought contain largely distinct regions for arm, leg and face (represented by “motor homunculus”). However, mounting evidence begun reveal a more intermixed, interrelated broadly tuned map. Here, we revisit homunculus using microelectrode array recordings from 20 arrays that sample PCG across 8 individuals, creating comprehensive map of...
Ventrolateral frontal area 44 is implicated in inhibitory motor functions and facilitating prefrontal control over vocalization. The contribution of corticostriatal circuits to unclear, as prior investigation projections the striatum-a central structure circuits-is limited. Here, we used anterograde retrograde tracing macaques map innervation zone projections, quantify their strengths, evaluate convergence with from other cortical regions. First, whereas terminal fields a rostral injection...
교육 패러다임의 변화에 따라 기능성게임을 이용한 교육방법에 대한 관심이 증가하고 있다. 하지만 교육용 기능성게임의 학습효과에 중점을 둔 결과 지향적 게임 디자인 설계는 게임의 재미적인 요소와 몰입감을 간과한 경우가 많으며, 지속적 학습참여와 같은 내재적 요인들을 반영하지 못했다. 지속적인 사용 및 확장과 학습 효과를 높여주기 위하여 학습자의 성향 인지확장에 변화를 반영한 게임디자인 설계가 필요하다. 본 연구에서는 인지심리학 모형을 바탕으로 한 설계전략을 문헌 리뷰를 통하여 분석 제시하고자 한다. 이는 학습자 질적 양적측면에서 긍정적 영향을 미칠 것으로 판단된다. The interests of education methods using Serious games have been increasing recently. But resu,lt-oriented game design framework not reflected intrinsic motivation. To increase...