A5011133923- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- CAR-T cell therapy research
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Viral Infections and Outbreaks Research
- Lysosomal Storage Disorders Research
- Adipokines, Inflammation, and Metabolic Diseases
- Proteoglycans and glycosaminoglycans research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Dendrimers and Hyperbranched Polymers
- 3D Printing in Biomedical Research
- Transgenic Plants and Applications
- Biochemical Analysis and Sensing Techniques
- Pregnancy and preeclampsia studies
- Respiratory viral infections research
- Chemical Synthesis and Analysis
- Herpesvirus Infections and Treatments
University of Canterbury
2023-2024
The University of Sydney
2020-2024
University of Otago
2013-2022
Duke University
2018-2020
Australian Regenerative Medicine Institute
2018
Maurice Wilkins Centre
2015-2018
Monash University
2018
Bournemouth University
2017
Cairns Hospital
2016
William James College
2014
Exosomes are 40-100 nm vesicles released by numerous cell types and thought to have a variety of roles depending on their origin. derived from antigen presenting cells been shown be capable initiating immune responses in vivo eradicating established tumours murine models. Tumour-derived exosomes can utilised as source tumour for cross-priming T-cells thus interest use anti-tumour immunotherapy. Further exploration into the protein composition may increase our understanding potential this...
The gut microbiota may be important in the postnatal development of immune system and hence influence prevalence atopic diseases. Bifidobacteria are most numerous bacteria guts infants, presence or absence certain species could determining geographic incidence We compared fecal populations bifidobacteria from children aged 25 to 35 days Ghana (which has a low atopy), New Zealand, United Kingdom (high-prevalence countries). Natal origin influenced detection bifidobacterial that samples almost...
It is well-accepted that maternal obesity affects fetal development to elevate the risk of offspring disease, but how this happens unclear. Understanding placental alterations during gestation as a consequence critical understanding impact on programming. Here, we used histological criteria, flow cytometry, quantitative PCR, and multiplex cytokine assays examine changes in cell proliferation inflammation placenta mouse model high-fat diet-induced obesity. We focused mid- late (approximately...
Abstract The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified cells, to solid tumors requires combinatorial strategies overcome immune suppression associated with the tumor microenvironment. Here we test whether inflammatory nature oncolytic viruses and their ability remodel microenvironment may help recruit potentiate functionality CAR cells. Contrary our hypothesis, VSVmIFNβ infection is attrition murine EGFRvIII cells in a...
Effective vaccines and immunotherapies against cancer require professional antigen‐presenting cells to cross‐present exogenous antigen initiate cytotoxic T‐cell responses destroy tumors. Virus‐like particles (VLPs), containing tumor antigens, which can immunize cancers, are cross‐presented by dendritic cell (DC) but the mechanism this occurs is not fully understood. Here, we used VLPs, derived from rabbit hemorrhagic disease virus (RHDV) with both murine human DCs, elucidate these pathways....
Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, anti-inflammatory normally discarded with placental tissue. We reasoned that their profile of biological features, wide availability, and the lack ethical barriers to use could make these useful as a therapy in ischemic stroke.We tested efficacy acute (1.5 hours) or delayed (1-3 days) poststroke intravenous injection hAECs 4 established animal models cerebral ischemia. Animals included young (7-14 weeks) aged mice...
Internalization of peptides by antigen presenting cells is crucial for the initiation adaptive immune response. Mannosylation has been demonstrated to enhance uptake through mannose receptors, leading improved responses. In this study we test effect surface mannosylation protein-based virus-like particles (VLP) derived from Rabbit hemorrhagic disease virus (RHDV) on murine and human cells. A monomannoside a novel dimannoside were synthesized successfully conjugated RHDV VLP capsid protein,...
We compared the test characteristics of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12(p-70), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), C-reactive protein (CRP), and full blood count (FBC) in diagnosis neonatal sepsis. This prospective cohort study Neonatal Intensive Care Unit Dunedin hospital patients between July 1, 2002 February 28, 2007 included 117 neonates commenced on antibiotics for 164 episodes suspected Blood cultures, FBC, CRP, IL-1β, TNF-α, PCT were obtained at time...
The impact of perceived child abuse history on 160 adult, Native American women's emotional well-being (i.e., depressive mood and anger) AIDS risk was examined. How sense mastery social support might lead to greater resiliency also investigated. Child physical-emotional found have anger than did sexual abuse. This finding independent current stress in lives. Women who were physically-emotionally abused as children had 5.14 times odds having a sexually transmitted disease their lifetimes...
Cervical cancer is caused by high-risk, cancer-causing human papillomaviruses (HPV) and the second highest cause of deaths in women globally. The majority cervical cancers express well-characterized HPV oncogenes, which are potential targets for immunotherapeutic vaccination. Here we develop a rabbit haemorrhagic disease virus (RHDV) virus-like particle (VLP)-based vaccine designed immunotherapy against HPV16 positive tumours. An RHDV-VLP, modified to contain universal helper T cell epitope...
<h3>Background</h3> Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination a promising alternative to conventional treatment colorectal cancer, using vaccines induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), form of non-infectious non-replicative subunit vaccine consisting rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing...
Anti-tumour T cell responses play a crucial role in controlling the progression of colorectal cancer (CRC), making this disease promising candidate for immunotherapy. However, to immune-targeted therapies are currently limited subpopulations patients and specific types cancer. Clinical studies have therefore focussed on identifying biomarkers that predict immunotherapy elucidating immunological landscapes different cancers. Meanwhile, our understanding how preclinical tumour models resemble...
Prior exposure of a vaccinee to certain species environmental mycobacteria can prime the immune system against common mycobacterial antigens, which in turn reduce subsequent efficacy live attenuated vaccines (such as Mycobacterium bovis BCG), both human and livestock vaccination programs. In this study, two strains avium, isolated from New Zealand livestock, were investigated determine their growth characteristics effects on murine models. Markedly different observed; an IS901-negative...
Orf virus (ORFV) is a zoonotic parapoxvirus that induces acute pustular skin lesions in sheep and humans. ORFV can reinfect its host the discovery of several secreted immune modulatory factors include chemokine-binding protein (CBP) may explain this phenomenon. Dendritic cells (DC) are professional antigen presenting induce adaptive immunity their recruitment to sites infection migration peripheral lymph nodes critically dependent on inflammatory constitutive chemokine gradients...
Conjugation of a vaccine adjuvant to an antigen enhances anti-tumor immune responses. Direct chemical conjugation, however, may limit their processing by the antigen-presenting cell for stimulation. To test this hypothesis, antigen-adjuvant conjugates were designed be cleaved intracellular trigger release and from each other. The different reductive environment inside outside cells was used as targeted release. Two redox-responsive disulphide linkers conjugate model ovalbumin CpG. In vitro...