Objective: To compare the toxicity of beta blockers in overdose and to identify clinical features predictive serious toxicity. Design: Comparison data collected prospectively on a relational database subjects presenting hospital with self-poisoning, coroner's prescription data. Setting: Newcastle Lake Macquarie, Australia, 1987-1995. Main Outcome Measures: Death, seizure, cardiovascular collapse, hypoglycemia, coma respiratory depression. Subjects: Fifty-eight self-poisonings two deaths...

Background Prediction of suicide risk is difficult in clinical practice. Aims To identify changes presentation predictive patients treated for repeated episodes self-poisoning. Method A nested case–control study used the Hunter Area Toxicology Service database to exposure variables and National Death Index suicide. Cases were who had hospital treatment on more than one occasion between 15 January 1987 31 December 2000. Results There cases, which 93 controls selected. Study associated with an...

Intensive insulin regimens are now the mainstay of modern, type 1 diabetes mellitus management. Insulin pumps (CSII) a key technique used. Although there has been considerable study outcomes, few recent data on CSII-associated adverse events (AEs) and their incidence characteristics.Phone calls to our 24-h support service were screened for AEs. Phone interviews conducted with parent/patient, within 96 h event. Interviews explored AE characteristics role user, as well questions relating...

Acetaminophen may increase International Normalized Ratio (INR) in patients taking anticoagulation medication, and with acetaminophen poisoning without hepatic injury. The objective of this study was to describe investigate the effect on INR. authors studied admitted a regional toxicology treatment center INR potentially confounding coingestion or Exposed nonexposed (control) cohorts were recruited from admissions psychotropic drug poisoning, respectively. From 1,437 poisonings, after...

We compared the test characteristics of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12(p-70), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), C-reactive protein (CRP), and full blood count (FBC) in diagnosis neonatal sepsis. This prospective cohort study Neonatal Intensive Care Unit Dunedin hospital patients between July 1, 2002 February 28, 2007 included 117 neonates commenced on antibiotics for 164 episodes suspected Blood cultures, FBC, CRP, IL-1β, TNF-α, PCT were obtained at time...

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To identify the incidence and risk of suicide self harm, among patients prescribed antidepressant drugs.

Aim To investigate the effect of sepsis upon volume distribution (Vd) gentamicin in neonates. Methods A retrospective chart review was conducted neonates admitted to Dunedin Hospital who had concentrations performed between 1st January 2000 and 30th October 2003. Data from 277 neonates, including a total 576 concentrations, were included pharmacokinetic analysis. Fifteen (5.4%) confirmed sepsis. Pharmacokinetic analyses with NONMEM using one compartment first order elimination model....

Objective: To analyze the risk factors for suicide, premature death and all-cause in a representative population of hospital-treated deliberate self-poisoning patients. Method: A prospective cohort study using data-linkage between Hunter Area Toxicology Service Database National Death Index Australian Institute Health Welfare, from January 1991 to December 2000. Results: There were 4105 subjects, whom 228 (5.6%) died, 122 (2.9%) by 58 (1.4%) suicide. The probability suicide after 10 years...

SUMMARY The aim of the present study was to perform an in vivo estimation Michaelis‐Menten constants major metabolic pathways paracetamol (APAP). A two‐occasion, single‐dose cross‐over trial performed using 60 and 90 mg/kg doses APAP healthy patients undergoing third molar dental extraction. Plasma samples were collected over 24 h urine for 8 after dosing. Twenty enrolled complete data plasma available both 13 volunteers who included analysis; seven men, median age (range) 22 years (19–31)...

Zopiclone is a hypnosedative structurally unrelated to the benzodiazepines but operating at same receptor complex. Although zopiclone has been used in clinical practice for many years, relatively little known of its relative toxicity comparison with other hypnosedatives.Deaths, where hypnosedatives were implicated, New Zealand (NZ) 2001 identified from chemical injury database. Prescription and aggregate defined daily dose (DDD) data forNZ obtained national prescribing Rates death per...

Aims To determine the paediatric licensing status in USA, UK, Australia and New Zealand of 79 medicines granted exclusivity to assess importance those practice. Methods The a patent extension USA as 10 November 2003 were identified from FDA website. Data on obtained Physicians Desk Reference (USA), Electronic Medicines Compendium (UK), Australian Prescription Products Guide (Australia) MedSafe website (New Zealand). A questionnaire was administered seven consultants PEMs for use children....