A5047494666- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Transgenic Plants and Applications
- Diabetes and associated disorders
- CAR-T cell therapy research
- Virus-based gene therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
University of Otago
2014-2021
<h3>Background</h3> Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination a promising alternative to conventional treatment colorectal cancer, using vaccines induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), form of non-infectious non-replicative subunit vaccine consisting rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing...
The results of adoptive T‐cell therapies (ACTs) are very encouraging and show clinical evidence that ACT can provide a cure for patients with metastatic disease. However, various response rates long‐term cancer remission have been observed in different trials. types T cells, prior treatment chemotherapy co‐administration other immune‐target found to influence the efficacy ACT. In this study, we investigate ability using CD4 + helper 1 (Th1) cells CD8 cytotoxic lymphocytes (CTLs) reject...
Breast cancer (BC) is the most frequently diagnosed in women, with many patients experiencing recurrence following treatment. Antigens delivered on virus-like particles (VLPs) induce a targeted immune response and here we investigated whether co-delivery of multiple antigens could superior anti-cancer for BC immunotherapy. VLPs were designed to recombinantly express murine survivin conjugated an aberrantly glycosylated mucin-1 (MUC1) peptide using intracellular cleavable bis-arylhydrazone...
In vivo and in vitro Cytotoxicity Gating Strategies. strategy used for identification of target cell populations an cytotoxicity assay. (a) Doublets were excluded by comparing side scatter (SS) interval (INT) against SS height (PEAK). (b) Live cells gated as negative Near-IR Live/Dead. (c) Target identified CFSE VPD staining, giving CFSEHi, CFSELo, CFSEHi/VPD stained populations. Unstained from Gate F partially masked to improve the comparison proportions between A similar gating was (d) INT...