A5010486628- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Down syndrome and intellectual disability research
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Brain Tumor Detection and Classification
- Machine Learning in Bioinformatics
- Diet and metabolism studies
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Primary Care and Health Outcomes
- Epigenetics and DNA Methylation
- Medical Education and Admissions
- Diversity and Career in Medicine
- Health, Environment, Cognitive Aging
- Innovations in Medical Education
- Prion Diseases and Protein Misfolding
- Machine Learning in Healthcare
- Amyotrophic Lateral Sclerosis Research
- Healthcare Policy and Management
University of California, Irvine
2015-2024
University of California, San Francisco
2024
San Francisco VA Medical Center
2024
Uniformed Services University of the Health Sciences
2016-2023
Cohort (United Kingdom)
2023
Center For Policy Research
2023
Agency for Healthcare Research and Quality
2023
UCLA Health
2022
Unifor
2022
Veterans Health Administration
2022
Abstract Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying layout. We tested large-scale structural in schizophrenia relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of network-level alterations. Leveraging anatomical MRI scans from 2439 adults 2867 healthy controls 26 ENIGMA sites data...
Abstract Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited group-level analyses, small and selective samples inpatients long time lags between exposure outcome. Methods This cross-sectional study pooled data from 20 sites participating the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted diffusion-weighted...
Virtually all people with Down syndrome (DS) develop neuropathology associated Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well elevated plasma concentrations neurofilament light chain (NfL) protein, are markers neurodegeneration late-onset AD. We hypothesized that EC gray matter loss increased NfL memory in adults DS.
Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment DS (MCI-DS) and test these hypotheses using cross-sectional longitudinal data. 18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze burden 58 participants clinically classified as cognitively stable (CS) or MCI-DS 12 CS participants. The study confirmed our increased inferior parietal,...
Background and Objectives: Collection of feedback regarding medical student clinical experiences for formative or summative purposes remains a challenge across settings. The purpose this study was to determine whether the use quick response (QR) code-linked online form improves frequency efficiency rater feedback. Methods: In 2016, we compared paper-based forms, an form, QR at 15 family medicine clerkship sites United States. Outcome measures included usability, number submissions per...
Despite the importance of identifying co-occurring psychiatric disorders in substance abuse treatment programs, there are few appropriate and validated instruments available to staff conduct brief screen for these conditions. This paper describes development, implementation validation a screening instrument mental health diagnoses trauma among diverse sample Black, Hispanic White women treatment. With input from clinicians consumers, we adapted longer existing into 14 question covering...
Background: Cryptococcus neoformans is an encapsulated yeast that commonly causes disease in individuals the setting of immunocompromised states. It rarely reported immunocompetent patients literature. Highlight a Report: An active duty service member with no significant medical history presented persistent headache, nausea, vomiting, weight loss, and nocturnal fevers for 2 months. The patient was admitted to hospital where lumbar puncture performed showing elevated white blood cell count,...
Changes in DoD policy now allow further discussion of well-documented health care needs and disparities lesbian, gay, bisexual, transgender (LGBT) patients among military medical students. Previous studies providers indicate knowledge comfort gaps LGBT exist. We performed a focused assessment sexual gender diversity education the undergraduate curriculum. Twenty-four Uniformed Service University (USU) School Medicine (SoM) faculty involved curriculum leadership, development or oversight...
Abstract While schizophrenia is considered a prototypical network disorder characterized by widespread brain-morphological alterations, it still remains unclear whether distributed structural alterations robustly reflect underlying layout. Here, we tested large-scale in relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2,439 adults with 2,867 healthy...
2][3][4] These disparities vary by service and specialty but remain pronounced, nonetheless.For example, women comprise 44% of early career (O3/LT) Family Physicians in the Navy; however, that percentage drops to only 12% at level O6/CAPT. 5 One initiative promote female officer retention through leadership development is MHS Female Physician Leadership Course (FPLC), held annually Defense Health Headquarters (DHHQ) Falls Church, Virginia.Mid-career physicians across all services are...
ABSTRACT Introduction There is increasing interest in assessing gender and race-based disparities academic medicine healthcare leadership civilian the U.S. Military Health System. Approximately 15% of active duty service members are women, racial minorities 30% total force. This study evaluates following factors among uniformed services family physicians: race representation attaining early career positions during training 2 years postresidency; perceptions regarding opportunities...
Abstract Introduction Having a mentor is associated with higher job satisfaction among U.S. physicians. The objective of this study was to assess military medical officers and if mentorship are intention continue service. Materials Methods This cross-sectional using voluntary, anonymous data from 2018 Uniformed Services Academy Family Physicians Annual Meeting registered attendees who completed an online Omnibus Survey. Outcome measures: work hours workload; voice in organizational...
Formal thought disorder (FTD) is a key clinical factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume deficiencies schizophrenia to be established large cohorts. Even less known about cellular basis FTD. Our study addresses these major obstacles based on multi-site cohort through ENIGMA Schizophrenia Working Group (752 individuals with 1256 controls), unravel neuroanatomy...
The Health Resources Allocation Model (HRAM) is an eLearning tool for health cadres and scientists introducing basic concepts of sub-national, rational district-based planning systems thinking under resources constraint. HRAM allows the evaluation resource allocation strategies in relation to key outcome measures such as coverage, equity services achieved number deaths disability-adjusted life years (DALYs) prevented. In addition, model takes into account geographical demographic...
ABSTRACT Introduction Active duty service women (ADSW) constitute 16% of the force. The prevalence alopecia, a dermatologic condition characterized by hair loss, is understudied in regard to hairstyle regulations across U.S. military services. Alopecia has several causes; one which due tension on scalp secondary tight hairstyles. In U.S., alopecia lifetime 1.7-2.1%; no previous studies evaluated this were found. Materials and Methods We used Military Health System Data Repository perform...
Overseas deployments place military personnel at risk for tropical diseases not typically observed on the U.S. mainland. This case describes first reported of brucellosis returning from Operation Enduring Freedom and Iraqi Freedom. A 31-year-old infantry soldier complained a 6-week history headaches, relapsing fever, constitutional symptoms since Iraq. was determined to have only brucellosis, but one many soldiers eating unpasteurized cheese local economy. Although malaria leishmaniasis...
Background: The purpose of this study was to examine factors associated with psychological resilience in a nationally representative sample West Point graduates. Aims: aims were (a) employ dimensional approach operationalizing trauma-exposed population that had been highly trained and educated persisting the face stress, previously unstudied, which we could correlates resilience, (b) identify key psychosocial factors, character traits, health variables, military experiences, coping...