A5062155936- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Mental Health Research Topics
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced MRI Techniques and Applications
- Machine Learning in Healthcare
- Traumatic Brain Injury Research
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Disease Mechanisms and Treatments
- Sleep and related disorders
- Medical Image Segmentation Techniques
- Anomaly Detection Techniques and Applications
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Tryptophan and brain disorders
- Meta-analysis and systematic reviews
Brigham Young University
2016-2024
Northwestern University
2009-2022
Cambridge University Press
2017
International Society of Nephrology
2017
Alzheimer's Association
2016
Banner Alzheimer’s Institute
2016
King's College London
2016
Ospedale Santa Maria della Misericordia di Udine
2016
University of Udine
2016
Institute of Behavioral Sciences
2009-2011
To examine the longitudinal course of primary progressive aphasia (PPA) over a 2-year period and to offer quantitative ranges expected change that could be used guide design evaluation therapeutic intervention trials.Regional changes cortical thickness whole-brain volume loss as well neuropsychological language performance were assessed at baseline 2 years later in 13 rigorously characterized patients who fulfilled research criteria for logopenic, agrammatic, semantic PPA subtypes (6 PPA-L,...
The syndrome of primary progressive aphasia (PPA) is diagnosed when a gradual failure word usage or comprehension emerges as the principal feature neurodegenerative disease.
Primary progressive aphasia (PPA) is a clinical dementia syndrome characterized by decline in language function but relative sparing of other cognitive domains. There are three recognized PPA variants: agrammatic, semantic, and logopenic. Although each subtype the nature principal deficit, individual patients frequently display subtle impairments additional The present study investigated distribution atrophy related to performance specific domains (i.e., grammatical processing, semantic...
<h3>Objective:</h3> The aim of this study was to provide quantitative measures changes in cortical atrophy over a 2-year period associated with 3 subtypes primary progressive aphasia (PPA) using whole-brain vertex-wise and region-of-interest (ROI) neuroimaging methods. purpose quantitate disease progression, establish an empirical basis for clinical expectations, outcome therapeutic trials. <h3>Methods:</h3> Changes thickness volume loss as well neuropsychological performance were assessed...
The semantic variant of primary progressive aphasia (PPA) is characterized by the combination word comprehension deficits, fluent and a particularly severe anomia. In this study, two novel tasks were used to explore factors contributing single most common factor was blurring distinctions among members category, leading errors overgeneralization in word–object matching as well definitions object descriptions. This more pronounced for natural kinds than artifacts. patients with anomias,...
Empathic deficits have been linked to poor functioning in schizophrenia, but this work is mostly limited self-report data. This study examined whether performance-based empathy measures account for incremental variance social competence and attainment above beyond self-reported empathy, neurocognition, clinical symptoms. Given the importance of working memory theoretical models prediction we also mediates relationship between functioning. Sixty outpatients 45 healthy controls were compared...
To identify features of primary progressive aphasia (PPA) associated with Alzheimer disease (AD) neuropathology. A related objective was to determine whether logopenic PPA is a clinical marker for AD.A total 139 prospectively enrolled participants root diagnosis constituted the reference set. Those autopsy or biomarker evidence AD, and who had been evaluated at mild stages (Aphasia Quotient ≥85), were included (n = 19). All quantitative language testing APOE genotyping. Fifteen MRI...
Cannabis use is associated with working memory (WM) impairments; however, the relationship between cannabis and WM neural circuitry unclear. We examined whether a disorder (CUD) was differences in brain morphology control subjects without CUD schizophrenia CUD, these related to history. Subjects group-matched on demographics included 44 healthy controls, 10 history, 28 no history of substance disorders, 15 Large-deformation high-dimensional mapping magnetic resonance imaging used obtain...
<h3>Objective:</h3> To determine if behavioral symptoms in patients with primary progressive aphasia (PPA) were associated degeneration of a ventral frontotemporal network. <h3>Methods:</h3> We used diffusion tensor imaging tractography to quantify abnormalities the uncinate fasciculus that connects anterior temporal lobe and ventrolateral frontal cortex. Two additional tracts studied: inferior fronto-occipital longitudinal fasciculus. also measured cortical thickness orbitofrontal regions...
The schizophrenia research community has invested substantial resources on collecting, managing and sharing large neuroimaging datasets. As part of this effort, our group collected high resolution magnetic resonance (MR) datasets from individuals with schizophrenia, their non-psychotic siblings, healthy controls siblings. This effort resulted in a growing resource, the Northwestern University Schizophrenia Data Software Tool (NUSDAST), an NIH-funded data project to stimulate new research....
Cannabis use has been associated with episodic memory (EM) impairments and abnormal hippocampus morphology among both healthy individuals schizophrenia subjects. Considering the hippocampus' role in EM, research is needed to evaluate relationship between cannabis-related hippocampal EM clinical groups. We examined differences control subjects without a past (not current) cannabis disorder (CUD). Subjects group-matched on demographics included 44 controls (CON), 10 CUD history (CON-CUD), 28...
Stroke often involves primary motor cortex (M1) and its corticospinal projections (CST). As hand function is critically dependent on these structures, recovery incomplete. The neuronal substrate supporting affected not well understood but likely reorganized M1 CST of the lesioned hemisphere (M1IL CSTIL). We hypothesized that in chronic stroke related to structural functional reorganization M1IL CSTIL. tested 18 patients with ischemic involving or CST. Their was compared age-matched healthy...
Abstract Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited group-level analyses, small and selective samples inpatients long time lags between exposure outcome. Methods This cross-sectional study pooled data from 20 sites participating the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted diffusion-weighted...
ABSTRACT While insomnia disorder is associated with changes in the brain, results vary across studies and levels of severity; no consistent morphometric pattern has yet emerged. Prior large‐scale genetic work implicated specific cortical subcortical regions pathophysiology insomnia. The aim current study to utilise surface‐based morphometry tools examine these regions, thereby offering new insights into from a genetically informed perspective. This leveraged archival neuroimaging data...