A5102738749- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Down syndrome and intellectual disability research
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Marine and coastal ecosystems
- Intimate Partner and Family Violence
- Mental Health Research Topics
- Pulmonary Hypertension Research and Treatments
- Health, Environment, Cognitive Aging
- Sarcoidosis and Beryllium Toxicity Research
- Water Quality Monitoring and Analysis
- Obstructive Sleep Apnea Research
- Career Development and Diversity
- Advanced Neuroimaging Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Interdisciplinary Research and Collaboration
- Neurofibromatosis and Schwannoma Cases
- Adolescent Sexual and Reproductive Health
- Nonprofit Sector and Volunteering
- Sexuality, Behavior, and Technology
- Prostate Cancer Diagnosis and Treatment
University of California, Irvine
2019-2025
University of Auckland
2023
University of Maine
2008-2015
Ohio Heart & Vascular Center
2007-2010
Fermi National Accelerator Laboratory
2009
University of South Florida St. Petersburg
2009
College of Marin
2009
University of North Texas
2006
University of North Texas Health Science Center
2006
Auburn University
2005
Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer's disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes subtle memory deficits observed during the preclinical stage. The heterogenous emergence deposition may selectively impact certain domains, which rely on distinct underlying neural circuits. In this context, we tested specific domains mnemonic discrimination, computation essential for episodic memory,...
Particulate matter concentration (PM, often referred to as total suspended solids [TSS]) is an important parameter in the evaluation of water quality. Several optical measurements used provide estimate turbidity have also been PM, among them light transmission, backscattering, and side‐scattering. Here we analyze such performed by Alliance for Coastal Technologies (ACT) at various coastal locations establish whether a given method performs better than others estimation PM. All technologies...
Mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical Alzheimer's disease. We tested whether functional connectivity (FC) within entorhinal–hippocampal circuit, measured with high-resolution resting state fMRI, associated mnemonic discrimination amyloid-β (Aβ) pathology sample 64 cognitively normal human older adults (mean age, 71.3 ± 6.4 years; 67% female). FC was between circuit...
Alzheimer's disease (AD) is the most common type of dementia, characterized by early memory impairments and gradual worsening daily functions. AD-related pathology, such as amyloid-beta (Aβ) plaques, begins to accumulate many years before onset clinical symptoms. Predicting risk for AD via related pathology critical preclinical stage could serve a therapeutic time window, allowing management reducing health economic costs. Current methods detecting however, are often expensive invasive,...
Abstract Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ] 42 /Aβ 40 , phosphorylated tau [p‐tau] 181 total [t‐tau]), positron emission tomography (PET; 18F‐florbetapir), high‐resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed....
Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment DS (MCI-DS) and test these hypotheses using cross-sectional longitudinal data. 18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze burden 58 participants clinically classified as cognitively stable (CS) or MCI-DS 12 CS participants. The study confirmed our increased inferior parietal,...
Ocean color, first measured from space 30 years ago, has provided a revolutionary synoptic view of near‐surface fields phytoplankton pigments. Since 1979, number ocean color satellite missions have coverage biomass and other biogeochemical variables on scales days to kilometers basin. Because the nature visible light its interaction with absorbing scattering materials in atmosphere, these measurements are biased toward waters obscured by clouds. As consequence, satellites miss significant...
Abstract Older adults may harbor large amounts of amyloid-β (Aβ) pathology, yet still perform at age-normal levels on memory assessments. We tested whether functional brain networks confer resilience or compensatory mechanisms to support in the face Aβ pathology. Sixty-five cognitively normal older received high-resolution resting state fMRI assess networks, 18F-florbetapir-PET measure Aβ, and a assessment. characterized with graph metrics local efficiency (information transfer), modularity...
Abstract Background Episodic memory is one of the first cognitive domains to decline in preclinical Alzheimer’s disease. We investigated whether graph metrics functional networks, specifically modularity and local efficiency, are related episodic amyloid‐β (Aβ) positivity cognitively normal older adults. Method Sixty‐five adults (mean age 72.3 ± 6.2 years; 62% female) underwent high‐resolution resting state fMRI (1.8mm 3 , partial acquisition) measure connectivity, 18F‐Florbetapir‐PET Aβ...
Abstract Obstructive sleep apnea (OSA) is common in older adults and associated with medial temporal lobe (MTL) degeneration memory decline aging Alzheimer’s disease (AD). However, the underlying mechanisms linking OSA to MTL impaired remains unclear. By combining magnetic resonance imaging (MRI) assessments of cerebrovascular pathology structure clinical polysomnography assessment overnight emotional retention at risk for AD, fronto-parietal brain regions was shown statistically mediate...
Abstract Adults with Down syndrome are less likely to have hypertension than neurotypical adults. However, whether blood pressure measures associated brain health and clinical outcomes in this population has not been studied detail. Here, we assessed pulse is markers of cerebrovascular disease linked a diagnosis dementia adults via structural imaging atrophy. The study included participants from the Alzheimer’s Disease - Syndrome (n = 195, age 50.6 ± 7.2 years, 44% women, 18% diagnosed...
Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer's disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes subtle memory deficits observed during the preclinical stage. The heterogenous emergence deposition may selectively impact certain domains, which rely on distinct underlying neural circuits. In this context, we tested specific domains mnemonic discrimination, computation essential for episodic memory,...
ABSTRACT Importance While the hallmark pathologies of amyloid-beta (Aβ) and tau in Alzheimer’s disease (AD) are well documented even part definition, upstream neuroinflammation is thought to play an important role but remains poorly understood. Objectives We tested whether two distinct neuroinflammatory markers associated with cerebrovascular injury Aβ, these plasma phosphorylated (pTau) concentration, medial temporal lobe (MTL) cortical hippocampal atrophy, memory deficits. examined YKL-40...
Research suggests a link between Alzheimer's Disease in Down Syndrome (DS) and the overproduction of amyloid plaques. Using Positron Emission Tomography (PET) we can assess in-vivo regional load using several available ligands. To measure distributions specific brain regions, atlas is used. A popular method creating to segment participant's structural Magnetic Resonance Imaging (MRI) scan. Acquiring an MRI often challenging intellectually-imparied populations because contraindications or...
Abstract INTRODUCTION Down syndrome (DS) is associated with elevated risk for Alzheimer’s disease (AD) due to beta amyloid (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals DS. METHODS acquired 18 F-Florbetapir PET scans from 19 nondemented DS at baseline and monitored them four years, five transitioning dementia. Machine learning classification determined features on standardized uptake value ratio (SUVR)...
Abstract Background Amyloid‐beta (Aβ) plaques are among the hallmark pathologies of Alzheimer’s disease (AD) and could potentially influence aggregation tau pathology, which is associated with neurodegeneration in AD. Prior work has demonstrated that left hippocampal atrophy present both mild cognitive impairment (MCI). However, these relationships not clear preclinical AD (i.e. those Aβ biomarkers but no clinical impairment). This study assesses relationship between pathology volume...
ABSTRACT Mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical Alzheimer’s disease. We tested if functional connectivity (FC) within entorhinal-hippocampal circuit, measured with high-resolution resting state fMRI, associated mnemonic discrimination Aβ pathology, PET, nondemented older adults. Low object performance was specifically increased FC between anterolateral entorhinal cortex...
Abstract Background An increase in global deposition of amyloid is known to be related declines a variety cognitive domains among people with Down syndrome (DS). Less the correspondence between increased regional load and specific functions. Since decline frontal lobe functions (e.g., attention, inhibitory control, shifting, motivation) considered by many key early indicator AD dementia adults DS, current study aims identify changes that are associated executive function (EF) both...