A5044646373- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Neural dynamics and brain function
- Restless Legs Syndrome Research
- Language Development and Disorders
- Physical Activity and Health
- Fractal and DNA sequence analysis
- Textile materials and evaluations
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Circadian rhythm and melatonin
- Resilience and Mental Health
- Health and Well-being Studies
- Advanced Computing and Algorithms
- Functional Brain Connectivity Studies
- Advanced Drug Delivery Systems
- Mechanical Behavior of Composites
- Children's Physical and Motor Development
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Child Nutrition and Feeding Issues
- Pain Mechanisms and Treatments
University of California, Irvine
2020-2024
UC Irvine Health
2023
Birla Institute of Technology and Science - Hyderabad Campus
2018
Birla Institute of Technology and Science, Pilani
2017
Saurashtra University
2015
Abstract Study Objectives Fast frequency sleep spindles are reduced in aging and Alzheimer’s disease (AD), but the mechanisms functional relevance of these deficits remain unclear. The study objective was to identify AD biomarkers associated with fast spindle cognitively unimpaired older adults at risk for AD. Methods Fifty-eight unimpaired, β-amyloid-negative, (mean ± SD; 61.4 6.3 years, 38 female) enriched parental history (77.6%) apolipoprotein E (APOE) ε4 positivity (25.9%) completed...
Abstract Background Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in impairment. rapid eye movement (REM) is usually more severe than non-rapid (NREM) sleep, but relative effect of oxyhemoglobin desaturation REM versus NREM on memory not completely characterized. Here, we examined impact OSA, as well moderating effects AD factors, verbal a sample...
Abstract Background Aging is associated with disruptions in non‐rapid eye movement (NREM) sleep and memory decline. Cerebral small vessel disease (CSVD) increases age clinical disturbance, but little known about its relationship local expression of NREM sleep. Here, we explore associations between CSVD burden, memory, electroencephalography (EEG) measures during older adults. Methods Fifteen cognitively intact adults (mean 71.8±6.3 years, 10 female, Apnea Hypopnea Index (AHI)=7.82±7.95)...
The purpose of this study was to prepare sustained release tablet moisture sensitive drug like Ranitidine Hydrochloride for treatment gastroesophageal reflux disease along with the improvement stability get better therapeutic efficacy.Pan coating technique used tablet. Film done using Eudragit RLPO and Eugragit EPO as polymer. 3(2) full factorial design applied optimization purpose, 9 runs were conducted. In that taken an independent variables gain Cummulative Drug Release (CDR) dependent...
Although cardiorespiratory fitness (CRF), an important marker of youth health, is associated with earlier sleep/wake schedule, its relationship circadian rhythms unclear. This study examined the associations between CRF and rhythm variables in adolescents. Eighteen healthy adolescents (10 females 8 males;
Aerobic fitness (AF) and sleep are major determinants of health in adolescents impact neurocognitive psychological development. However, little is known about the interactions between AF during developmental transition experienced across adolescence. This study aimed to consider relationships habitual patterns neurophysiology healthy adolescents.Subjects (mean age = 14.6 ± 2.3 years old, range 11-17, 11 females) were evaluated for (peak VO2 assessed by ramp-type progressive cycle ergometry...
Abstract Obstructive sleep apnea (OSA) is common in older adults and associated with medial temporal lobe (MTL) degeneration memory decline aging Alzheimer’s disease (AD). However, the underlying mechanisms linking OSA to MTL impaired remains unclear. By combining magnetic resonance imaging (MRI) assessments of cerebrovascular pathology structure clinical polysomnography assessment overnight emotional retention at risk for AD, fronto-parietal brain regions was shown statistically mediate...
Abstract Introduction Memory consolidation is facilitated by trace reactivation during non-rapid eye movement slow wave sleep (SWS), involving reinstatement of a hippocampal index driving integration activity patterns stored in cortical modules. Slow oscillation (SO) and spindle (SP) coupling reflects this process. Here, we used novel graph theory approach to examine whether network modularity (Q) the relative import hippocampus amygdala function, measured eigenvector centrality (EC)...
Abstract Introduction Obstructive sleep apnea (OSA) is associated with disturbances, memory impairment, and dementia risk in older adults. The impact of OSA on neurophysiology related function remains unclear. We examined associations among severity, non-rapid eye movement (NREM) expression, overnight retention cognitively intact adults at for Alzheimer’s disease (AD). Methods Overnight clinical polysomnography (PSG) 256-channel electroencephalography (EEG) was conducted 81 (aged 61.68◻5.99...
Abstract Introduction Structural changes emblematic of brain development, e.g., synaptic pruning/myelination, are theorized to impact sleep architecture, local physiology, and sleep-dependent cognition. Conventional analyses in relying on absolute or relative power from electroencephalography (EEG) study the function rhythms, have disregarded 1/f EEG law as “neural noise". However, evidence tying steepness (1/f exponent) intercept offset) curve excitatory-inhibitory (E/I) balance...
Abstract Introduction Alzheimer’s disease (AD) is a world-wide healthcare crisis among older adults. Sex, aging, and apolipoprotein E (APOE) genotype are the most impactful risk factors for AD. Sleep beneficial memory changes with age. We aimed to test whether sex APOE (ε4-carriers/non-carriers) interact impact sleep-dependent consolidation (SDMC). Methods tested 67 adults (41 women, 25 ε4-carriers, mean±SD; 61.8±6.1 years). Participants encoded word-pairs in evening, were immediately, then...
Abstract Introduction Aging is associated with disruptions in non-rapid eye movement (NREM) sleep expression, but the mechanisms driving this effect remain unclear. Cerebral small vessel disease (CSVD) burden increases age and clinical disturbance, little known about its relationship local expression of oscillatory activity during NREM sleep. Here, we explore associations between CSVD electroencephalography (EEG) measures older adults. Methods Fifteen cognitively intact adults (mean 71.8±6.3...
Abstract Importance Preserving the ability to vividly recall emotionally rich experiences contributes quality of life in older adulthood. While prior work suggests that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends salient memories consolidated during sleep. Objective To investigate associations between engagement (PA) and overnight emotional memory retention examine theoretically replacing 30-minutes lower-intensity with MPA associated...
Abstract Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of delays, neurobiology underlying such challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands 3-to-6-month-old infants an autistic sibling, followed by accelerated increases age. Here we apply new methods to decompose spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity explore possible links between...
Preserving the ability to vividly recall emotionally rich experiences contributes quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends salient memories consolidated during sleep. In current study, adults (mean age = 72.3 ± 5.8) completed an overnight polysomnography assessment with emotional memory tested before and after sleep a self-report questionnaire assessing habitual PA....
Abstract Background Alzheimer’s disease (AD) is a world‐wide healthcare crisis among older adults. Sex, aging, and apolipoprotein E ( APOE ) genotype are the most impactful risk factors for AD. Sleep beneficial memory changes with age. We aimed to test whether sex (ε4‐carriers/non‐carriers) interact impact sleep‐dependent consolidation (SDMC). Methods tested 67 adults (41 women, 25 ε4‐carriers, mean±SD; 61.8±6.1 years). Participants encoded word‐pairs in evening, were immediately, then...
Abstract Background Aging is associated with disruptions in non‐rapid eye movement (NREM) sleep and memory decline. Cerebral small vessel disease (CSVD) increases age clinical disturbance, but little known about its relationship local expression of NREM sleep. Here, we explore associations between CSVD burden, memory, electroencephalography (EEG) measures during older adults. Methods Fifteen cognitively intact adults (mean 71.8±6.3 years, 10 female, Apnea Hypopnea Index (AHI) = 7.82±7.95)...
Today, Polymerase Chain Reaction (PCR) based DNA amplification plays an indispensable role in the field of biomedical research. Its inherent ability to exponentially amplify sample has proven useful for identification virulent pathogens like those causing Multiple Drug-Resistant Tuberculosis (MDR-TB). The intervention Microfluidics technology revolutionized concept PCR from being a laborious and time consuming process into one that is faster, easily portable capable multifunctional....
Abstract Introduction Aging is accompanied by increased insomnia and memory decline. Enhancing GABAergic antagonizing orexinergic function are both ways to treat insomnia, but how these mechanisms impact sleep oscillations, consequently memory, among older adults with unknown. Thus, chronic effects of zolpidem lemborexant on quantitative electroencephalography (EEG) quality were evaluated. Methods 116 (71.01±4.81y, 78.67% female) (Insomnia Severity Index 18.73±3.13) completed a phase 3 study...
SUMMARY Memory consolidation occurs via reactivation of a hippocampal index during non-rapid eye movement slow-wave sleep (NREM SWS) which binds attributes an experience existing within cortical modules. For memories containing emotional content, hippocampal-amygdala dynamics facilitate over bout. This study tested if modularity and centrality—graph theoretical measures that the level segregation/integration in system relative import its nodes—map onto central tenets memory theory...
<title>Abstract</title> <bold>Background</bold>: Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in impairment. rapid eye movement (REM) is usually more severe than non-rapid (NREM) sleep, but relative effect of oxyhemoglobin desaturation REM versus NREM on memory not completely characterized. Here, we examined impact OSA, as well moderating effects AD...
Abstract Background Sleep apnea is a type of sleep‐disordered breathing that increases risk for Alzheimer’s disease‐related pathology potentially through cerebrovascular pathology, likely exacerbated by two features sleep apnea: intermittent hypoxia and fragmentation. White matter hyperintensities (WMH), marker small vessel disease, increase in aging AD. Here, we tested the hypothesis apnea‐related hypoxemia severity, not fragmentation, are associated with WMH volume older adults. Method...