A5072745300- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
- Telomeres, Telomerase, and Senescence
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Sleep and Wakefulness Research
- Sleep and related disorders
- Bioinformatics and Genomic Networks
- Sphingolipid Metabolism and Signaling
- Memory and Neural Mechanisms
- Cancer-related cognitive impairment studies
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
Roche (Switzerland)
2020-2023
Roche Pharma AG (Germany)
2021-2023
Hospital Del Mar
2021-2022
Centre for Genomic Regulation
2021-2022
Institute of Science and Technology
2022
Lundbeck (Denmark)
2021-2022
Institut de Biologia Evolutiva
2022
Universitat Pompeu Fabra
2021-2022
University College London
2021-2022
UK Dementia Research Institute
2021-2022
The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation the immune system causes sickness behaviors that present during a episode (MDE), such as low mood, anhedonia, anorexia, weight loss. Second, peripheral markers inflammation are frequently reported disorder. Third, illnesses associated with high rates MDEs. However, fundamental limitation paucity evidence brain MDE. Translocator protein density measured...
Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood individuals with Alzheimer disease (AD). However, it not known whether there are differences GFAP levels across entire AD continuum its performance similar to CSF GFAP.To evaluate plasma throughout continuum, from preclinical dementia, compared GFAP.This observational, cross-sectional study collected data July 29, 2014, January 31, 2020, 3 centers. The...
Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, loss of neurons in the substantia nigra. It now known that pathological process may begin decades before clinical diagnosis include a variety neuronal alterations addition to system.This study examined density all synapses with synaptic vesicle glycoprotein 2A (SV2A) subjects mild bilateral (n = 12) matched normal controls using vivo high-resolution positron emission tomographic imaging as...
There is a great need for fully automated plasma assays that can measure amyloid beta (Aβ) pathology and predict future Alzheimer's disease (AD) dementia.
Neuroinflammation and abnormal immune responses have been implicated in schizophrenia (SCZ). Past studies using positron emission tomography (PET) that examined neuroinflammation patients with SCZ vivo the translocator protein 18kDa (TSPO) target were limited by insensitivity of first-generation imaging agent [(11)C]-PK11195, scanners used, small sample sizes studied. Present study uses a novel second-generation TSPO PET radioligand...
[ 18 F]-FEPPA binds to the 18-kDa translocator protein (TSPO) and is used in positron emission tomography (PET) detect microglial activation. However, quantitative interpretations of PET signal with new generation TSPO radioligands are confounded by large interindividual variability binding affinity. This presents as a trimodal distribution, reflecting high-affinity binders (HABs), low-affinity binder (LAB), mixed-affinity (MABs). Here, we show that one polymorphism (rs6971) located exon 4...
Objective: Neuroinflammation and abnormal immune responses are increasingly implicated in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) studies targeting translocator protein 18 kDa (TSPO) have been limited by high nonspecific binding first-generation radioligand, low-resolution scanners, small sample sizes, psychotic patients being on antipsychotics or not first episode their illness. The present study uses novel second-generation TSPO PET radioligand...
Abstract Introduction Further evidence is needed to support the use of plasma amyloid β (Aβ) biomarkers as Alzheimer's disease prescreening tools. This study evaluated clinical performance and robustness Aβ 42 /Aβ 40 for positivity prescreening. Methods Data were collected from 333 BioFINDER 121 Disease Neuroimaging Initiative participants. Risk predictive values versus percentile actionability , simulations modeled impact potential uncertainties biases. Amyloid PET was brain amyloidosis...
Abstract Introduction The effect of random error on the performance blood‐based biomarkers for Alzheimer's disease (AD) must be determined before clinical implementation. Methods We measured test‐retest variability plasma amyloid beta (Aβ)42/Aβ40, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau (p‐tau)217 simulated effects this biomarker when predicting either cerebrospinal fluid (CSF) Aβ status or conversion to AD dementia in 399 non‐demented...
Abstract INTRODUCTION A hallmark of Alzheimer's disease (AD) is the aggregation proteins (amyloid beta [A] and hyperphosphorylated tau [T]) in brain, making cerebrospinal fluid (CSF) particular interest. METHODS We conducted a CSF proteome‐wide analysis among participants varying AT pathology ( n = 137 participants; 915 proteins) with nine biomarkers neurodegeneration neuroinflammation. RESULTS identified 61 significantly associated category P < 5.46 × 10 −5 ) 636 significant...
Abstract Age-related disease may be mediated by low levels of chronic inflammation (“inflammaging”). Recent work suggests that gut microbes can contribute to via degradation the intestinal barrier. While aging and age-related diseases including Alzheimer’s (AD) are linked altered microbiome composition higher microbial components in systemic circulation, role remains unclear. To investigate whether greater is associated with advanced age AD pathology, we assessed fecal samples from older...
Abstract Study Objectives Fast frequency sleep spindles are reduced in aging and Alzheimer’s disease (AD), but the mechanisms functional relevance of these deficits remain unclear. The study objective was to identify AD biomarkers associated with fast spindle cognitively unimpaired older adults at risk for AD. Methods Fifty-eight unimpaired, β-amyloid-negative, (mean ± SD; 61.4 6.3 years, 38 female) enriched parental history (77.6%) apolipoprotein E (APOE) ε4 positivity (25.9%) completed...
Importance Knowledge is lacking on the prevalence and prognosis of individuals with a β-amyloid–negative, tau-positive (A−T+) cerebrospinal fluid (CSF) biomarker profile. Objective To estimate CSF A−T+ profile investigate its clinical implications. Design, Setting, Participants This was retrospective cohort study cross-sectional multicenter University Gothenburg (UGOT) (November 2019-January 2021), longitudinal Alzheimer Disease Neuroimaging Initiative (ADNI) (individuals mild cognitive...
An unmet need exists for reliable plasma biomarkers of amyloid pathology, in the clinical laboratory setting, to streamline diagnosis Alzheimer's disease (AD). For routine use, a biomarker must provide robust and results under pre-analytical sample handling conditions. We investigated impact different procedures on levels seven development potential use AD. Using (1) fresh (never frozen) (2) previously frozen plasma, we evaluated effects (A) storage time temperature, (B) freeze/thaw (F/T)...
Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether function elevated immigrants compared nonimmigrants relationship with psychosis. Two complementary case-control studies vivo (stress-induced release capacity) were performed Canada United Kingdom. Canadian study included 25 immigrant 31 nonmigrant...
Glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). fibrillary acidic protein (GFAP) relates reactive astrogliosis and can measured both cerebrospinal fluid (CSF) blood. Plasma GFAP has been suggested become earlier AD than its CSF counterpart. Although astrocytes consume approximately half glucose-derived energy brain, relationship between cerebral glucose metabolism poorly understood. Here, we aimed investigate association fluorodeoxyglucose...
Abstract Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer’s disease (AD). We aimed to evaluate potential causal role TL in AD endophenotypes (i.e . , cognitive performance, N = 2233; brain age and AD-related signatures, 1134; cerebrospinal fluid biomarkers (CSF) neurodegeneration, 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted context ALFA (ALzheimer FAmilies) study,...
Higher grey matter volumes/cortical thickness and fluorodeoxyglucose uptake have been consistently found in cognitively unimpaired individuals with abnormal Alzheimer's disease biomarkers compared those normal biomarkers. It has hypothesized that such transient increases may be associated neuroinflammatory mechanisms triggered response to early pathology. Here, we evaluated, the earliest stages of continuum, associations between volume CSF several pathophysiological known altered preclinical...
<h3>Background and Objectives</h3> To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of Alzheimer continuum associated with disease (AD) risk factors, primary pathology, neurodegeneration markers. <h3>Methods</h3> This cross-sectional study was performed Alzheimer9s Families (ALFA+) cohort, comprising middle-aged cognitively unimpaired participants. neurogranin growth-associated protein-43 (GAP-43) were measured immunoassays, synaptosomal-associated...