A5091789530- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Aging and Gerontology Research
- Cognitive Abilities and Testing
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Cancer-related cognitive impairment studies
- Tryptophan and brain disorders
- Psychological Well-being and Life Satisfaction
- Health Policy Implementation Science
- Epilepsy research and treatment
- Health disparities and outcomes
- Advanced Causal Inference Techniques
- Folate and B Vitamins Research
- Hormonal Regulation and Hypertension
- Down syndrome and intellectual disability research
- Sleep and Wakefulness Research
- Mental Health Research Topics
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Decision-Making and Behavioral Economics
University of Wisconsin–Madison
2018-2025
Georgia Institute of Technology
2014-2020
Duke University
2016
Johns Hopkins University
2016
National Institute on Aging
2016
North Carolina State University
2011-2015
Royal Women's Hospital
1981
The University of Melbourne
1981
To examine whether long-term measures of cortisol predict Alzheimer disease (AD) risk.We used a prospective longitudinal design to dysregulation was related AD risk. Participants were from the Baltimore Longitudinal Study Aging (BLSA) and submitted multiple 24-hour urine samples over an average interval 10.56 years. Urinary free (UFC) creatinine (Cr) measured, UFC/Cr ratio calculated standardize UFC. measure regulation, we within-person level (i.e., mean), change in time slope), variability...
We examined age differences in the effort required to perform basic cognitive operations needed achieve a specified objective outcome, and how hypothesized increases requirements later life are related intrinsic motivation associated with enjoyment of participation effortful activities. Young (N = 59; 20-40 years) older 57; 64-85 adults performed memory-search task varying difficulty across trials, systolic blood pressure responsivity-calculated as increase over baseline during...
Abstract INTRODUCTION A hallmark of Alzheimer's disease (AD) is the aggregation proteins (amyloid beta [A] and hyperphosphorylated tau [T]) in brain, making cerebrospinal fluid (CSF) particular interest. METHODS We conducted a CSF proteome‐wide analysis among participants varying AT pathology ( n = 137 participants; 915 proteins) with nine biomarkers neurodegeneration neuroinflammation. RESULTS identified 61 significantly associated category P < 5.46 × 10 −5 ) 636 significant...
Importance Knowledge is lacking on the prevalence and prognosis of individuals with a β-amyloid–negative, tau-positive (A−T+) cerebrospinal fluid (CSF) biomarker profile. Objective To estimate CSF A−T+ profile investigate its clinical implications. Design, Setting, Participants This was retrospective cohort study cross-sectional multicenter University Gothenburg (UGOT) (November 2019-January 2021), longitudinal Alzheimer Disease Neuroimaging Initiative (ADNI) (individuals mild cognitive...
Objectives.We tested the hypothesis that aging is associated with an increase in effort and costs cognitive activity using systolic blood pressure (SBP) as a measure of effort.
The impact of task complexity on information search strategy and decision quality was examined in a sample 135 young, middle-aged, older adults. We were particularly interested the competing roles fluid cognitive ability domain knowledge experience, with former being negative influence latter positive adults' performance. Participants utilized 2 matrices, which varied complexity, regarding consumer purchase. Using process tracing software an algorithm developed to assess strategy, we...
We investigated how information search strategies used to support decision making were influenced by self-related implications of the task individual. Consistent with notion selective engagement, we hypothesized that increased self-relevance would result in more adaptive behaviors and this effect be stronger older adults than younger adults. examined 79 81 using a process-tracing procedure 2 different tasks. The impact motivation (i.e., implications) was manipulating social accountability...
Abstract Background Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies but not associated with tau tangles neuropathological research inconsistently cerebrospinal fluid P-tau181. IR are well-recognized vascular factors. Some suggest that cardiovascular may act synergistically cortical amyloid measured using PET. Utilizing data from largely nondemented middle-aged older adult cohorts enriched AD risk, we...
Abstract INTRODUCTION Understanding how a research sample compares to the population from which it is drawn can help inform future recruitment planning. We compared Wisconsin Alzheimer's Disease Research Center (WADRC) participant state (WI‐pop) on key demographic, social exposome, and vascular risk measures. METHODS The WADRC included 930 participants. Population statistics were estimated using several national data sources. WI‐pop for two age groups, 45–64 years ≥65 years, separately....
The present study examined the day-to-day fluctuation of state-like anticipatory coping (coping employed prior to stressors) and how these processes relate important outcomes for older adults (i.e., physical health, affect, memory failures). Forty-three aged 60–96 ( M = 74.65, SD 8.19) participated in an 8-day daily diary coping, stressors, failures. Participants reported behaviors on one day with respect 6 distinct stressor domains that could occur following day. Multilevel models indicated...
Abstract Previous studies suggest associations between self-reported sleep problems and poorer health, cognition, Alzheimer’s disease pathology dementia-related outcomes. It is important to develop a deeper understanding of the relationship these complications disturbance, modifiable risk factor, in late midlife, time when may be accruing. The objectives this study included application unsupervised machine learning procedures identify distinct subgroups persons with problematic association...
Insulin sensitivity, pancreatic β-cell function, fasting glucose, and 2-h post-load glucose were related to cognition in cognitively healthy nondiabetic older adults. Thirty-five adults (⩾65 years) underwent a oral tolerance test cognitive testing. Seventeen had normal 18 intermediate hyperglycaemia or prediabetes (World Health Organization criteria). Fasting test–derived measures of function (oral disposition index) insulin sensitivity analysed as predictors four domains: verbal episodic...
Down syndrome (DS) is the most prevalent genetic cause of intellectual disability, resulting from trisomy 21. Recently, positron emission tomography (PET) imaging has been used to image synapses in vivo. The motivation for this pilot study was investigate whether synaptic density low functioning adults with DS can be evaluated using PET radiotracer [11C]UCB-J. Data were acquired (n = 4) and older neurotypical (NT) 37). Motion during scans required use a 10-minute acquisition window...
Serum FSH and LH total urinary oestrogens were measured in 20 mature onset postmenopausal diabetic women compared to nondiabetic matched for age, years since menopause, surface area per cent ideal weight. Significantly higher levels of oestrone, oestradiol oestriol significantly lower found the women. Closer analysis these findings showed that differences maintained diabetics who required insulin adequate control, whereas controlled on diet alone or oral hypoglycaemic drugs not different...
Abstract Background Mild behavioral impairment (MBI) is associated with all‐cause dementia. Little known about MBI’s effects on cognitive function among individuals in earlier disease stages, particularly racially diverse samples. We examined relationships between MBI and decline a richly characterized sample of white African American (AA) older‐middle aged adults. AA participants were enrolled Americans Fighting Alzheimer’s Midlife (AA‐FAIM), an ancillary study the Wisconsin Disease...
Abstract Background Non‐Hispanic Black Americans (BA) have increased prevalence of cardiovascular disease (CVD) risk factors and elevated for end‐stage renal (ESRD). CVD factors, potentially ESRD, heighten dementia risk; however, the association kidney function to cognition in cognitively unimpaired (CU) BA adults remains understudied. We tested whether global risk, individual less healthy moderated associations between age cognitive performance middle‐aged older adult BAs who were CU at...
Research and theory have shown a link between heart rate reactivity during cognitive testing extraversion in younger adults; however, similar work has not been conducted with older adults. This study was designed to explore age extraversion-related differences within-person (HR) two working memory tasks of varying difficulty using multi-level modeling approach. Across 570 total assessments continuous HR monitoring, 28 adults ( M = 19.76, SD 1.15) 29 71.19, 6.63) were administered (backward...
Abstract A major hallmark of Alzheimer’s disease (AD) is the aggregation proteins (β-amyloid (A) and hyperphosphorylated tau (T)) in brain, which makes AD proteome cerebrospinal fluid (CSF) particular interest. Here, we conducted a CSF proteome-wide analysis among participants with without pathology (n = 137 total participants: 56 A-T-, 39 A+T-, 42 A+T+; 915 analyzed), using panel 9 biomarkers for neurodegeneration neuroinflammation. We identified 61 significantly associated AT category (P...
Abstract Background African Americans (AA) are under‐represented in Alzheimer’s disease (AD) biomarker research. Blood‐based biomarkers for AD offer the promise of greater diversity research studies, but little is known about performance these within an AA cohort. We examined association between modifiable and non‐modifiable risk factors on trajectory plasma measures Aβ 42/40 a large well‐characterized Method N =318 participants enrolled Fighting Mid‐Life (AA‐FAIM) provided 690 samples. The...
Abstract Background Synaptic loss is a major feature of symptomatic Alzheimer’s disease (AD). PET radioligands for synaptic vesicle glycoprotein 2A (SV2A) provide an index density in the brain. While development these tracers advance field AD, little yet known about regional synapse AD or extent to which accounts cognitive dysfunction vivo . Here we tested whether measured with [ 11 C]UCB‐J associated cognition. Secondarily, examined association between tau, using 18 F]MK‐6420 PET, and...