A5011043449- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Spinal Cord Injury Research
- Tryptophan and brain disorders
- Gut microbiota and health
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Stress Responses and Cortisol
- Music Therapy and Health
- Health, Environment, Cognitive Aging
- Stroke Rehabilitation and Recovery
- Family and Disability Support Research
- Folate and B Vitamins Research
- Respiratory Support and Mechanisms
- Dysphagia Assessment and Management
- Neonatal Respiratory Health Research
- Child Development and Education
University of Kentucky
2020-2024
University of Wisconsin–Madison
2018-2021
Abstract Background Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in impairment. rapid eye movement (REM) is usually more severe than non-rapid (NREM) sleep, but relative effect of oxyhemoglobin desaturation REM versus NREM on memory not completely characterized. Here, we examined impact OSA, as well moderating effects AD factors, verbal a sample...
The apolipoprotein E (
Genetic factors are key to understanding recovery following spinal cord injury (SCI). Prior work conducted in our laboratory demonstrated that APOE genotype impacts respiratory plasticity after cervical SCI. Specifically, female mice expressing the APOE4 allele had impairments their ability generate and maintain robust diaphragmatic activity SCI intermittent hypoxia treatment relative APOE3 counterparts. Subsequently we showed different alleles leads altered neural control even without a...
Impairments following spinal cord injuries (SCI) are due to the primary trauma and secondary complications. Secondary complications include 1) degeneration of white matter tracts 2) persistent neuroinflammation. Here we test a novel compound, NOVO-118 that is designed mitigate these in rodent model SCI. an antagonist low-density lipoprotein receptor regulated protein 1 (LRP1) which expressed all cell types central nervous system. Antagonism LRP1 neurons implicated promoting axon regeneration...
High cervical spinal cord injuries (SCI) damage of bulbospinal inputs to phrenic motor neurons results in diaphragm paresis and paralysis. Additionally, acute respiratory distress syndrome (ARDS) lung injury (ALI) is prevalent individuals with SCI (Veeravagu et al., 2013). We have recently shown that a rat model recapitulates inflammatory metabolic symptoms ARDS/ALI (Huffman 2021). Measurements are typically performed at endpoint, therefore do not allow researchers perform longitudinal or...
Spinal cord injury (SCI) is a devastating condition characterized by impaired motor and sensory function, as well internal organ pathology dysfunction. This dysfunction, particularly gastrointestinal (GI) complications, neurogenic bowel, can reduce the quality of life individuals with an SCI potentially hinder their recovery. The gut microbiome impacts various central nervous system functions has been linked to number health disease states. An imbalance microbiome, i.e., dysbiosis,...
<title>Abstract</title> <bold>Background</bold>: Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in impairment. rapid eye movement (REM) is usually more severe than non-rapid (NREM) sleep, but relative effect of oxyhemoglobin desaturation REM versus NREM on memory not completely characterized. Here, we examined impact OSA, as well moderating effects AD...
Obesity at midlife is associated with over a threefold increased risk for Alzheimer's disease, while being overweight two-fold risk. Visceral obesity may be more harmful than overall body weight, but remains understudied regard to cognitive function. Given that critical period when trajectories of decline begin, we sought test the relationship between visceral adiposity and function among middle-aged adults. We hypothesized higher would poorer performance on testing. Cognitively unimpaired...
Obstructive sleep apnea (OSA) is associated with increased risk of developing dementia due to Alzheimer's disease. OSA characterized by repeated pauses in breathing, accompanied transient hypoxemia. may increase for affecting brain regions that are sensitive intermittent hypoxemia, such as the hippocampus. The goal this study was test whether disordered breathing affects hippocampal volume middle-aged adults. Cognitively unimpaired adults untreated were recruited from Wisconsin ADRC (N=73;...
Unlike insulin resistance (IR), less is known about secretion (IS) as a predictor of cognition, cerebral glucose uptake, and brain amyloid, even though impaired IS has been related to increased Alzheimer's disease (AD) risk. In nondiabetic cognitively-healthy adults, we hypothesized that IR decreased would be worse cognition groups with higher lower have uptake amyloid. Participants (N = 87) were enrolled at the Wisconsin Disease Research Center (P50AG033514;sub-project). Insulin from 2-hour...
Obstructive Sleep Apnea (OSA) affects approximately 10% of middle-aged adults and has been linked with increased risk for dementia due to Alzheimer's disease. Despite accumulating knowledge detailing the role sleep in neurological health, there are still gaps understanding effect disorders on memory. OSA is a factor cognitive decline, yet exactly how memory not clear. We have previously found that associated high levels neurofilament light protein (NFL) CSF, indicating axonal degeneration....
Obstructive Sleep Apnea (OSA) affects approximately 10% of middle-aged adults and has been linked with increased risk for dementia due to Alzheimer's disease. Despite accumulating knowledge detailing the role sleep in neurological health, there are still gaps understanding effect disorders on memory. OSA is a factor cognitive decline, yet exactly how memory not clear. We have previously found that associated high levels neurofilament light protein (NFL) CSF, indicating axonal degeneration....
Obstructive sleep apnea (OSA) is associated with increased risk of developing dementia due to Alzheimer's disease. OSA characterized by repeated pauses in breathing, accompanied transient hypoxemia. may increase for affecting brain regions that are sensitive intermittent hypoxemia, such as the hippocampus. The goal this study was test whether disordered breathing affects hippocampal volume middle-aged adults. Cognitively unimpaired adults untreated were recruited from Wisconsin ADRC (N=73;...
Cerebral glucose uptake has been shown to decline years in advance of symptomatic Alzheimer's disease (AD). Insulin resistance (IR) – a risk factor for AD - related decreased cerebral cross-sectional research but longitudinal studies are lacking. A consequence IR is increased insulin production, which may elevate beta-amyloid by competitively blocking degradation insulin-degrading-enzyme. Whether secretion (IS) hypometabolism unknown. We hypothesized that higher baseline and IS healthy...
Nearly 60% of all spinal cord injuries (SCI) occur at the cervical level. These high-level can lead to quadriplegia, autonomic dysregulation, and interruption descending respiratory pathways required for breathing. As motor function is life, it critical restore breathing as soon possible after SCI. Indeed, therapeutic techniques in animal studies have been successful restoring SCI; however, these interventions appear be more effective chronic than acute timepoints post-injury. One potential...
Breathing is vital for life and both uniquely complex vulnerable to disruption. Disorders of breathing such as those that occur in sleep apnea even high cervical spinal cord injury (SCI) can impair quality potentiate the ill effects comorbidities like Alzheimer's disease (AD). Indeed, studies have shown greater cognitive cardiovascular impairments subjects with AD. Apolipoprotein E (ApoE) a ubiquitous protein found throughout body CNS which aids regulation transport cholesterol lipids....
Breathing is essential to life and can be easily disrupted by many adverse events. Disorders such as high cervical spinal cord injury (SCI) sleep apnea decrease quality of enhance the ill effects comorbidities like Alzheimer's disease (AD). Previous studies have shown an increase in cognitive impairments subjects with both AD. Apolipoprotein E (ApoE) a protein found throughout body central nervous system (CNS) that involved regulation transport cholesterol lipids. Out three APOE human...
ABSTRACT The apolipoprotein (APOE) gene has been studied due to its influence on Alzheimer’s disease (AD) development and work in an APOE mouse model recently demonstrated impaired respiratory motor plasticity following spinal cord injury (SCI). Individuals with AD often co-present obstructive sleep apnea (OSA) characterized by cessations breathing during sleep. Despite the prominence of genotype sex as factors progression, little is known about impact these variables control. Ventilation...