A5064381058- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
University of Kentucky
2022-2024
The apolipoprotein E (
Breathing is essential to life and can be easily disrupted by many adverse events. Disorders such as high cervical spinal cord injury (SCI) sleep apnea decrease quality of enhance the ill effects comorbidities like Alzheimer's disease (AD). Previous studies have shown an increase in cognitive impairments subjects with both AD. Apolipoprotein E (ApoE) a protein found throughout body central nervous system (CNS) that involved regulation transport cholesterol lipids. Out three APOE human...
ABSTRACT The apolipoprotein (APOE) gene has been studied due to its influence on Alzheimer’s disease (AD) development and work in an APOE mouse model recently demonstrated impaired respiratory motor plasticity following spinal cord injury (SCI). Individuals with AD often co-present obstructive sleep apnea (OSA) characterized by cessations breathing during sleep. Despite the prominence of genotype sex as factors progression, little is known about impact these variables control. Ventilation...