A5087584357- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Sleep and Work-Related Fatigue
- Educational and Psychological Assessments
- Impact of Light on Environment and Health
- Neuroscience and Music Perception
- Childhood Cancer Survivors' Quality of Life
- High Altitude and Hypoxia
- Infant Development and Preterm Care
- Neural dynamics and brain function
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Stress Responses and Cortisol
- Epilepsy research and treatment
- Neurogenetic and Muscular Disorders Research
- Tryptophan and brain disorders
- Children's Physical and Motor Development
- Pediatric Pain Management Techniques
- Neuroscience and Neuropharmacology Research
- Autoimmune and Inflammatory Disorders Research
University of Wisconsin–Madison
2012-2025
Midlands Partnership NHS Foundation Trust
2021
Obstructive sleep apnea (OSA) is associated with significant alterations in neuronal integrity resulting from either hypoxemia and/or loss. A large body of imaging research supports reductions gray matter volume, white and resting state activity, functional abnormalities response to cognitive challenge various brain regions patients OSA. In this study, we used high-density electroencephalography (hdEEG), a tool that could potentially be during routine clinical care, examine the regional...
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by disrupting motor enactments during REM sleep, but also cognitive impairments across several domains. In addition to abnormalities, we hypothesized that RBD patients may display EEG abnormalities NREM sleep. We collected all-night recordings with 256-channel high-density in nine patients, predominantly early-onset medicated individuals, sex- and age- matched healthy controls, additional controls medications...
Sleep slow wave activity, as measured using EEG delta power (<4 Hz), undergoes significant changes throughout development, mirroring in brain function and anatomy. Yet, age-dependent variations the characteristics of individual waves have not been thoroughly investigated. Here we aimed at characterizing properties such origin, synchronization, cortical propagation transition between childhood adulthood.We analyzed overnight high-density (256 electrodes) recordings healthy typically...
We have previously shown that the White-crowned Sparrow (WCS) decreases sleep by 60% during a period of migratory restlessness relative to non-migratory when housed in 12 h light: dark cycle. Despite this reduction, accuracy operant performance was not impaired, and fact rates responding were elevated period, effects opposite those routinely observed following enforced deprivation. To determine whether increases due improved or migration on activity level, here we assessed using task which...
Abstract Introduction Slow waves are a key feature of high-quality, restorative sleep that occur during non-rapid eye movement (NREM) sleep, which comprises 75–80% total time spent in sleep. Left ventromedial prefrontal cortex (vmPFC) regions have been shown to be prominent “hot spot” where slow generated. Slow-wave activity (SWA) is homeostatically regulated, believed reflect the renormalization synaptic strength counteracts potentiation and cellular stress wake. Disrupted SWA has...
Abstract Recent evidence shows that identifying and treating epileptiform abnormalities in patients with Alzheimer’s disease could represent a potential avenue to improve clinical outcome. Specifically, animal human studies have revealed the early phase of disease, there is an increased risk seizures. It has also been demonstrated administration anti-seizure medications can slow functional progression only EEG signs cortical hyperexcitability. In addition, although it not known at what stage...
Summary Emotion processing abnormalities and sleep pathology are central to the phenomenology of paediatric posttraumatic stress disorder, disturbance has been linked development, maintenance severity disorder. Given emerging evidence indicating a role for in emotional brain function, it proposed that dysfunctional experiences during may play significant affective disorders, including Here we sought examine relationship between emotion typically developing youth, youth with diagnosis...
Sleep disturbance is a core symptom of Pediatric post-traumatic stress disorder (PPTSD). Given the link between sleep and affective processing, disruptions in sleep-dependent processing emotional material have been suggested to contribute maintenance. In this study we sought asses relationship emotion youth with PPTSD relative healthy control subjects. Seven participants PTSD (aged 14.5 ± 2.9; CAPS-CA score 64.8 17.8) three age- sex- matched controls 12.0 0.8) completed two overnight...
Obstructive sleep apnea (OSA) is associated with increased risk of developing dementia due to Alzheimer's disease. OSA characterized by repeated pauses in breathing, accompanied transient hypoxemia. may increase for affecting brain regions that are sensitive intermittent hypoxemia, such as the hippocampus. The goal this study was test whether disordered breathing affects hippocampal volume middle-aged adults. Cognitively unimpaired adults untreated were recruited from Wisconsin ADRC (N=73;...
Obstructive sleep apnea (OSA) is associated with increased risk of developing dementia due to Alzheimer's disease. OSA characterized by repeated pauses in breathing, accompanied transient hypoxemia. may increase for affecting brain regions that are sensitive intermittent hypoxemia, such as the hippocampus. The goal this study was test whether disordered breathing affects hippocampal volume middle-aged adults. Cognitively unimpaired adults untreated were recruited from Wisconsin ADRC (N=73;...
Abstract Introduction Sleep disturbance is central to the phenomenology of PTSD across lifespan with up 90% youth reporting sleep disturbance. Subjective dysfunction has also been linked development, maintenance and severity disorder. However, date there have no objective EEG assessments in PTSD, little known about how disease impacts specific features. Methods Ten (aged 14.5±3.2; CAPS-CA score 60.5±25.3) ten age-and sex-matched typically developing (TD) 14.7±3.2) completed two...
Abstract Introduction Parasomnia episodes (PE) consist of abnormal behaviors during sleep. Using high-density EEG (HDEEG), we sought to quantify topographical differences in spectral power PE comparison wake and Methods 17 adult subjects with a history NREM sleep parasomnia underwent 256-electrode HDEEG recordings recovery after 25h deprivation. occurred either spontaneously or when triggered by sound. Data preprocessing PE, data included filtering at 1-25 Hz, careful epoch channel...
Abstract Introduction Daytime neurobehavioral impairments are commonly associated with sleep disordered breathing (SDB) in children. However, a large number of studies have shown only minimal differences between children SDB relative to control children, suggesting that dysfunction is not responsible for daytime impairment. Importantly, however, previous measured EEG using frontal scalp electrodes, failing capture the regional features prominent during development. Here we measure hdEEG and...
Abstract Introduction Sleep state misperception, or paradoxical insomnia, is a condition whereby an individual reports being awake even though polysomnographic evidence confirms they were asleep. Normally, indication of sleep misperception determined by asking patient to estimate the amount wakefulness experienced after full night laboratory-monitored sleep. While clinically useful, this crude, post-hoc assessment does little inform neurobiological underpinnings misperception. Here we used...
Abstract Aims Nearly a third of U.S. veterans who deployed in support the 1990-1991 Persian Gulf War are affected by illness (GWI). Here we aimed to characterize whether subjective sleep complaints GWI associated with objective EEG disturbances relative healthy and controls; show alterations neural activity during that differentiate them from subjects. Main methods We used high-density (HDEEG) assess regional patterns rapid eye movement (REM) non-REM (NREM) between three groups: male fatigue...
Abstract Case report - Introduction Needle phobia is a common issue amongst children, particularly with long-term illnesses requiring repeated interventions. Psychological interventions such as coping strategies and distraction techniques can be effective in many of these but not universally successful. Recent research has reportedthat the use virtual reality (VR) headsets technique at alleviating both pain fear children receiving intravenous (IV) injections, cannulation venepuncture....