A5061699054- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Bipolar Disorder and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Neurology and Historical Studies
- Transplantation: Methods and Outcomes
- Healthcare professionals’ stress and burnout
- Advanced Neuroimaging Techniques and Applications
- Hallucinations in medical conditions
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Music Perception
- Pharmacological Effects and Toxicity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Resilience and Mental Health
- Mitochondrial Function and Pathology
- Diet and metabolism studies
Monash University
2019-2024
The Alfred Hospital
2020-2024
Australian Regenerative Medicine Institute
2023
Alfred Health
2020-2023
King's College London
2010-2021
Kings Health Partners
2011-2016
The Royal Melbourne Hospital
2014-2016
Psychiatry Research Trust
2013-2016
South London and Maudsley NHS Foundation Trust
2012-2015
National Health Service
2013
There is growing interest in the complex topology of human brain functional networks, often measured using resting-state MRI (fMRI). Here, we used a meta-analysis large primary literature that fMRI or PET to measure task-related activation (>1,600 studies; 1985-2010). We estimated similarity (Jaccard index) patterns across experimental tasks between each pair 638 regions. This continuous coactivation matrix was build weighted graph characterize network topology. The modular, with occipital,...
Objective: To examine psychological distress in healthcare workers (HCWs) during the COVID-19 pandemic April–May 2020. Methods: A cross-sectional survey examining demographic, employment and mental health characteristics of HCWs a large metropolitan hospital Australia. Results: showed significant symptoms moderate-severe level depression (21%), anxiety (20%) posttraumatic stress disorder (PTSD; 29%), associated with burnout, prior psychiatric history, profession resilience. Conclusion:...
Abstract The purpose of this research is to determine the impact working during early stage COVID‐19 pandemic on well‐being staff at one 600‐bed acute hospital in metropolitan Melbourne, Australia. This exploratory study part a larger mixed methods survey project, reporting qualitative data from an on‐line clinical between April 16th and May 13th, 2020 pandemic. Responses five free‐text questions were analysed using inductive content analysis. 321 medical, nursing, allied health non‐clinical...
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective study was to examine relationship between childhood function early Secondary objectives were compare exposure young people at ultra high (UHR) healthy volunteers. Sixty-seven adults, comprising 47 individuals UHR for 20 volunteers recruited from same geographic area matched age, gender...
Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether function elevated immigrants compared nonimmigrants relationship with psychosis. Two complementary case-control studies vivo (stress-induced release capacity) were performed Canada United Kingdom. Canadian study included 25 immigrant 31 nonmigrant...
Abstract Animal models of psychosis propose that abnormal hippocampal activity drives increased subcortical dopamine function, which is thought to contribute aberrant salience processing and psychotic symptoms. These effects appear be mediated through connections between the hippocampus, ventral striatum/pallidum midbrain. The aim present study was examine connectivity in this pathway people at ultra high risk (UHR) for psychosis. Functional magnetic resonance imaging used compare neural...
Childhood trauma has been implicated as a risk factor for the etiology of psychogenic nonepileptic seizures (PNES). Relatively little attention paid to whether profiles specific types differ between patients with epilepsy and PNES. Investigating childhood in these patient groups may identify psychological vulnerabilities that predispose developing PNES, aid early diagnoses, prevention, treatment.Data were collected from two cohorts (nRetrospective = 203; nProspective 209) admitted...
Cognitive models suggest that auditory verbal hallucinations arise through defective self-monitoring and the external attribution of inner speech. We used a paradigm engages (VSM) to examine whether this process is impaired in people experiencing prodromal symptoms, who have very high risk developing psychosis.We tested 31 individuals with an At-Risk Mental State (ARMS) healthy volunteers. Participants read single adjectives aloud while source pitch online feedback was manipulated, then...
Abstract Background Phenylketonuria (PKU) is an autosomal recessive inherited disorder characterised by a deficiency in phenylalanine hydroxylase. Untreated, PKU associated with wide range of cognitive and psychiatric sequelae. Contemporary management guidelines recommend lifetime dietary control (Phe) levels, however many individuals who discontinue subsequently suffer symptoms anxiety, depression disturbances to cognition. We undertook prospective cohort study patients early-treated...
Patients diagnosed with functional (psychogenic nonepileptic) seizures have similar or greater levels of disability, morbidity and mortality than people epilepsy, but there are far fewer treatment services. In contrast to the current understanding pathophysiological mechanisms development evidence-based treatments for is rudimentary. This leads high direct healthcare costs indirect patient, family wider society. There many clinician system-level barriers improving outcomes seizures. At a...
Abstract Objective Mental health complaints are prevalent among people with epilepsy, yet there major barriers that prevent access to psychological care, including high out‐of‐pocket costs and a lack of accessible specialized services. The purpose the current study is examine comparative efficacy, acceptability, cost‐effectiveness, long‐term outcomes digital intervention when delivered under two models care (i.e., guided vs. unguided) in supporting mental functioning adults epilepsy. Method...
Abstract Objective This study was undertaken to identify factors that predict discordance between the screening instruments Neurological Disorders Depression Inventory for Epilepsy (NDDI‐E) and Generalized Anxiety Disorder scale (GAD‐7), diagnoses made by qualified psychiatrists among patients with seizure disorders. Importantly, this is not a validation study; rather, it investigates clinicodemographic predictors of tests psychiatric assessment. Methods Adult admitted inpatient...
Background. The definition of ultra-high risk (UHR) for psychosis was derived from community-based help-seeking populations. Prisoners have high rates and other severe mental health (MH) problems. They also factors psychiatric morbidity yet they are among the populations who less likely to seek help in community. Despite a policy equivalence care individuals prison there no early intervention services prisons UK. This study exploring feasibility introducing such service into local London...
Biases in cognition such as Jumping to Conclusions (JTC) and Verbal Self-Monitoring (VSM) are thought underlie the formation of psychotic symptoms. This prospective study people with an At Risk Mental State (ARMS) for psychosis examined how these cognitive biases changed over time, predicted clinical functional outcomes. Twenty-three participants were assessed at presentation a mean 31 months later. Performance on JTC VSM tasks measured both time points. Relationships symptom severity, level...
Sensorimotor gating, measured as the modification of eye blink startle reflexes to loud acoustic stimuli by quieter preceding stimuli, is altered in those with psychosis, their relatives and at high clinical risk for psychosis. Alterations have also been shown cannabis users, albeit a lesser extent, known factor onset psychosis clinically genetically susceptible individuals. We examined interaction between use on sensorimotor both Prepulse Inhibition (PPI) Facilitation (PPF). tested PPI PPF...
Introduction This study aims to validate the Seizure-Related Impact Assessment Scale (SERIAS). novel patient-reported outcome measure (PROM) compares ‘trade-off’ between seizures and treatment-related adverse effects, measures epilepsy disability qualitatively quantitively. It fills an important gap in PROMs for clinical trials practice. Methods analysis Adults with epileptologist-confirmed from two Australian Epilepsy Centres are being recruited. People functional seizures, or who unable...