A5005225645- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Identity, Memory, and Therapy
- Neuroscience and Neuropharmacology Research
- Mental Health and Psychiatry
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Memory Processes and Influences
- Sleep and Wakefulness Research
- Child and Adolescent Psychosocial and Emotional Development
- Obstructive Sleep Apnea Research
- Genetics and Neurodevelopmental Disorders
- Neurology and Historical Studies
- Personality Disorders and Psychopathology
- Neuroscience of respiration and sleep
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and related disorders
The University of Melbourne
2016-2025
Austin Health
2016-2025
Austin Hospital
2020-2024
Alfred Health
2018-2024
The Alfred Hospital
2019-2024
Monash University
2019-2024
The Royal Melbourne Hospital
2022-2024
Florey Institute of Neuroscience and Mental Health
2015-2023
Australian Psychological Society
2010-2023
Mental Health Australia
2020
Purpose: Both neurobiologic and psychosocial factors have been proposed to account for the high prevalence of depression surrounding epilepsy surgery. Using a prospective longitudinal approach, this study aimed profile evolution after surgery at multiple time points, including early longer-term follow-up. We also sought identify predictors before surgery, whether patients undergoing mesial temporal lobe resection (MTR) were greater risk than nonmesial (NMTR). Methods: Sixty (38 MTR, 22 NMTR)...
<h3>Objective:</h3> To define the functional network changes that characterize MRI-negative temporal lobe epilepsy (TLE) and TLE with hippocampal sclerosis (HS-TLE). <h3>Methods:</h3> We studied 36 patients medically refractory unilateral TLE, having either a normal clinical MRI (n = 18) or 18). Patients were compared to healthy controls of equivalent age sex 27). Functional connectivity in 10 minutes task-free was assessed using voxel-resolution graph theoretic analysis, metrics degree,...
Summary Objectives The Psychology Task Force of the Medical Therapies Commission International League Against Epilepsy (ILAE) has been charged with taking steps to improve global mental health care for people epilepsy. This study aimed inform direction and priorities by examining epilepsy healthcare providers’ current practical experiences, barriers, unmet needs around addressing depression anxiety in their patients. Methods A voluntary 27‐item online survey was distributed via ILAE chapters...
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis epilepsy (POE). Methods Patients POE recruited to an genetics research program underwent phenotyping genetic analysis. The latter included screening for rare pathogenic variants in genes, polygenic risk score (PRS) calculation common associated schizophrenia. Results One hundred twenty‐two individuals were identified. Eighty‐six 122 (70%) had interictal psychosis, schizophrenia most phenotype (36/86,...
SEEG cortical stimulation enables individualised mapping of language networks. Regions associated with induced deficits are marked as 'language-positive' and considered important in supporting function. It remains unclear, however, whether small lesions sites created by radiofrequency thermocoagulation sufficient to cause deficits. Thirty-six consecutive patients drug resistant focal epilepsy were prospectively recruited from two Australian centres. Formal assessment was undertaken before...
Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture network activity at the maximal temporal resolution of acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods voxels. We use it here to examine how dynamics connections regional networks are...
In this study, we aimed to uncover distinct antecedents of autobiographic memory dysfunction in patients with epilepsy early (childhood/adolescence) vs late (adulthood) disease onset.One hundred sixty-six adults participated: 92 focal epilepsy, whose cognitive and psychiatric functioning were compared that 74 healthy controls. Predictors deficit contrasted between early-onset (n = 47) late-onset 45) epilepsy.Overall, people performed significantly worse on measures both semantic episodic...
the skill of absolute pitch (ap) has been proposed as an ideal paradigm for investigating complex relationships that exist between genome and its expression at a cognitive behavioral level (the phenotype). Yet despite this, we still have limited understanding early conditions might be necessary or sufficient development this skill, influence current music environment not explored. To investigate these issues undertook detailed characterization 160 musicians, then identified factors...
Childhood trauma has been implicated as a risk factor for the etiology of psychogenic nonepileptic seizures (PNES). Relatively little attention paid to whether profiles specific types differ between patients with epilepsy and PNES. Investigating childhood in these patient groups may identify psychological vulnerabilities that predispose developing PNES, aid early diagnoses, prevention, treatment.Data were collected from two cohorts (nRetrospective = 203; nProspective 209) admitted...
<h3>Objective</h3> Patients with temporal lobe epilepsy (TLE) are similar in their epileptology regardless of whether they have a lesion evident on MRI; this study aims to prospectively clarify also neuropsychological profiles. <h3>Methods</h3> Participants comprised 152 adults: 79 patients TLE and 73 healthy controls. controls did not differ age, sex, or education (<i>p</i> > 0.05). Sixty-two percent had an MRI-resolvable (39% presumed hippocampal sclerosis [HS-TLE], 61% other than HS...
This review poses the question: Does disruption to cognitive brain networks in epilepsy contribute problem of comorbid depression? Initial evidence suggests that network disease gives rise seizures has a predilection for same cognition-related regulate mood, with comorbidity reflective more extensive disease. Framing both and its psychiatric comorbidities terms dysfunction overlapping (cognitive) raises possibility depression can be primary feature some cases facilitates an classification...
Psychoses affecting people with epilepsy increase disease burden and diminish quality of life. We characterized postictal psychosis, which comprises about one quarter epilepsy-related psychoses, has unknown causation.We conducted a case-control cohort study including patients diagnosed confirmed by psychiatric assessment, available data regarding epilepsy, treatment, history, psychosis profile, outcomes. After screening 3,288 patients, we identified 83 psychosis; 49 had psychosis. Controls...
Cortical stimulation is an important component of stereoelectroencephalography (SEEG). Despite this, there currently no standardized approach and significant heterogeneity in the literature regarding cortical practices. Via international survey SEEG clinicians, we sought to examine spectrum practices reveal areas consensus variability.A 68-item questionnaire was developed understand including neurostimulation parameters, interpretation epileptogenicity, functional cognitive assessment...
Summary Purpose: To assess the impact of childhood‐onset temporal lobe epilepsy (TLE) on attainment normative developmental tasks and identify predictors long‐term outcomes. Methods: In 1992–1993, a prospective longitudinal cohort study TLE was commenced in State Victoria, Australia. At review 2004–2006, we assessed tasks, which are age‐specific individual psychosocial achievements tied to particular phases lifespan. The comprised 54 individuals (33 female) with mean age 20 years (range...
Patients diagnosed with functional (psychogenic nonepileptic) seizures have similar or greater levels of disability, morbidity and mortality than people epilepsy, but there are far fewer treatment services. In contrast to the current understanding pathophysiological mechanisms development evidence-based treatments for is rudimentary. This leads high direct healthcare costs indirect patient, family wider society. There many clinician system-level barriers improving outcomes seizures. At a...
Abstract Objective Mental health complaints are prevalent among people with epilepsy, yet there major barriers that prevent access to psychological care, including high out‐of‐pocket costs and a lack of accessible specialized services. The purpose the current study is examine comparative efficacy, acceptability, cost‐effectiveness, long‐term outcomes digital intervention when delivered under two models care (i.e., guided vs. unguided) in supporting mental functioning adults epilepsy. Method...
Abstract Objective This study was undertaken to identify factors that predict discordance between the screening instruments Neurological Disorders Depression Inventory for Epilepsy (NDDI‐E) and Generalized Anxiety Disorder scale (GAD‐7), diagnoses made by qualified psychiatrists among patients with seizure disorders. Importantly, this is not a validation study; rather, it investigates clinicodemographic predictors of tests psychiatric assessment. Methods Adult admitted inpatient...
At present there is considerable variability in the psychiatric evaluation and follow-up of patients epilepsy surgery programs globally. There a large body research now demonstrating heightened risk for psychological disturbance surgically remedial before after surgery. This evidence provides compelling case routine provision treatment to optimize benefits patient outcomes. In comprehensive model care, presurgical psychosocial plays an integral role shaping team's understanding surgical...