A5019984111- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Metabolism and Genetic Disorders
- Tuberous Sclerosis Complex Research
- Psychosomatic Disorders and Their Treatments
- Blind Source Separation Techniques
- Organ Donation and Transplantation
- Botulinum Toxin and Related Neurological Disorders
- Spatial Cognition and Navigation
- Health, Environment, Cognitive Aging
- Hemispheric Asymmetry in Neuroscience
- Pain Mechanisms and Treatments
St Vincent's Hospital
2014-2024
Swinburne University of Technology
2019-2024
The University of Melbourne
2014-2024
The Royal Melbourne Hospital
1998-2024
Monash University
2024
Austin Health
2019-2023
St Vincent's Health
2023
St. Vincent's Birmingham
2006-2023
St. Vincent's Hospital
2023
Saint Vincent's Catholic Medical Center
2023
Drug-resistant focal epilepsy is a major clinical problem and surgery under-used. Better non-invasive techniques for epileptogenic zone localization are needed when MRI shows no lesion or an extensive lesion. The interictal ictal before propagation from the zone. High-density EEG (HDEEG) magnetoencephalography (MEG) offer millisecond-order temporal resolution to address this but co-acquisition challenging, MEG studies rare, long-term prospective lacking, fundamental questions remain. Should...
See Duchowny (doi: 10.1093/aww216 ) for a scientific commentary on this article . Multiple seizure foci, propagation and epileptic spasms complicate presurgical localization in tuberous sclerosis. Furthermore, controversy exists about the contribution of tubers, perituberal cortex underlying genetic abnormality to epileptogenesis. We aimed determine epileptogenic substrate sclerosis by studying spatio-temporal patterns onset intracranial EEG recordings which multiple depth surface electrodes...
<h3>Objective</h3> To identify brain regions underlying interictal generalized paroxysmal fast activity (GPFA), and their causal interactions, in children adults with Lennox-Gastaut syndrome (LGS). <h3>Methods</h3> Concurrent scalp EEG-fMRI was performed 2 separately analyzed patient groups LGS: 10 (mean age 8.9 years) scanned under isoflurane-remifentanil anesthesia 15 older patients 31.7 without anesthesia. Whole-brain event-related analysis determined GPFA-related activation each group....
Summary: EEG source imaging (ESI) has gained traction in recent years as a useful clinical tool for the noninvasive surgical work-up of patients with drug-resistant focal epilepsy. Despite its proven benefits temporo-spatial modeling spike and seizure sources, ESI remains widely underused practice. This partly relates to lack clarity around an optimal approach acquisition processing scalp data purpose ESI. Here, we describe some practical considerations application We focus on patient...
This study aims to determine whether there are important clinico-electrical differences between patients with temporal lobe epilepsy (TLE) secondary mesial sclerosis (MTS) and those TLE a discrete neocortical lesion (NL). The case histories, interictal EEG, seizure semiology, ictal EEG postoperative outcome of 46 pathologically proven (31 MTS 15 NL) were compared. A history febrile convulsions (FC) was more common in (58% versus 26%, P < 0.05), as significant cerebral event at <4 years age...
Summary: Purpose : Adult epilepsy studies have demonstrated cerebral and cerebellar volume reduction beyond the epileptogenic zone, correlating this with an inferior surgical outcome. We determined whether brain volumes were reduced in childhood significance of this. Methods Cerebral, cerebellar, hippocampal measured by quantitative magnetic resonance imaging on 112 children (ages 4–18) syndrome video‐EEG telemetry. Eighty‐seven had partial 25 generalized or indeterminate syndrome. Normative...
Abstract Modelling the interactions that arise from neural dynamics in seizure genesis is challenging but important effort to improve success of epilepsy surgery. Dynamical network models developed physiological evidence offer insights into rapidly evolving brain networks epileptic seizure. A limitation previous studies this field dependence on invasive cortical recordings with constrained spatial sampling regions might be involved dynamics. Here, we propose virtual intracranial...
SEEG cortical stimulation enables individualised mapping of language networks. Regions associated with induced deficits are marked as 'language-positive' and considered important in supporting function. It remains unclear, however, whether small lesions sites created by radiofrequency thermocoagulation sufficient to cause deficits. Thirty-six consecutive patients drug resistant focal epilepsy were prospectively recruited from two Australian centres. Formal assessment was undertaken before...
We used transcranial magnetic stimulation to investigate whether the cortical excitability changes observed amongst different generalized and focal epilepsy syndromes are reflected in their asymptomatic siblings if these depended on clinical phenotype. studied 157 patients with (95 62 focal) (138 82, respectively). Motor threshold paired pulse at short (2, 5, 10 15 ms) long (100–300 interstimulus intervals were measured. Results compared those of 12 control subjects 20 siblings. There no...
We examined the factors related to brain volume reduction in a pediatric sample of patients that included those with nonintractable epilepsy.Entry criteria were children less than 18 years old epilepsy referred for MRI, including whole volumetric sequence. The size was 231. Risk ascertained from interviews and reviews medical records. Factors age onset, seizure years, family history, status epilepticus, intellectual disability, febrile convulsions. MRI data obtained 44 normal childhood...
To investigate whether using transcranial magnetic stimulation (TMS) to derive if measures of cortical excitability changes can distinguish between various adolescent/adult-onset generalized epilepsy syndromes at different phases the disorder.One hundred thirty-seven patients with divided into juvenile myoclonic epilepsy, absence and tonic-clonic seizures only were studied. The cohorts further drug naive-new onset, refractory, seizure-free groups. Motor threshold (MT) paired pulse TMS short...
Abstract Introduction The current study examined the contributions of comprehensive neuropsychological assessment and volumetric selected mesial temporal subregions on structural magnetic resonance imaging (MRI) to identify patients with amnestic mild cognitive impairment (aMCI) probable Alzheimer's disease (AD) dementia in a memory clinic cohort. Methods Comprehensive automated entorhinal, transentorhinal, hippocampal volume measurements were conducted 40 healthy controls, 38 subjective...
<b><i>Objective:</i></b> To examine the clinical, electrographic, and quantitative MRI differences between frontal lobe (FLE) mesial temporal epilepsy (MTLE) in children. <b><i>Methods:</i></b> The population included children who underwent video-EEG monitoring 1995 2000 were classified as either FLE (n = 39) or MTLE 17) according to criteria of International League Against Epilepsy. Clinical, EEG, data (including cortical volumes) compared two syndromes a control group 42)....
Approximately 30% of patients admitted for video-EEG monitoring have psychogenic nonepileptic seizures (PNES). Differentiation "convulsive" PNES from convulsive can be difficult. The EEG often displays rhythmic movement artifact that may resemble seizure activity and confound the interpretation. We sought to determine whether time-frequency mapping during reveals a pattern differs epileptic seizures.EEGs 15 consecutive with PNESs were studied by using NEUROSCAN compared seizures. Fast...
Summary Purpose Transcranial magnetic stimulation ( TMS ) was used to characterize measurable changes of cortical excitability in patients who were undergoing medical and surgical management temporal lobe epilepsy TLE investigate whether these alterations depended on timing achieving seizure control throughout the course illness method management. Methods Eighty‐five with divided into (1) drug naive–new onset, (2) early medically refractor, (3) late refractory, (4) seizure‐free antiepileptic...