A5101472280- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Traumatic Brain Injury Research
- Pharmacological Effects and Toxicity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Cerebrospinal fluid and hydrocephalus
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
- Menopause: Health Impacts and Treatments
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Fetal and Pediatric Neurological Disorders
Monash University
2018-2025
Alfred Health
2023-2025
The Royal Melbourne Hospital
2016-2023
The University of Melbourne
2016-2023
The Alfred Hospital
2019-2022
There are no treatments in clinical practice known to mitigate the neurobiological processes that convert a healthy brain into an epileptic one, phenomenon as epileptogenesis. Downregulation of protein phosphatase 2A, causes hyperphosphorylation tau, is implicated neurodegenerative diseases commonly associated with epilepsy, such Alzheimer's disease and traumatic injury. Here we used 2A activator sodium selenate investigate role three different rat models epileptogenesis: amygdala kindling,...
Abstract Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely tied to pathophysiology disorder, with hypofunction N -methyl- d -aspartate receptors (NMDAr) implicated as having a crucial role. Prepulse inhibition (PPI) is behavioural measure sensorimotor gating disrupted schizophrenia. We tested ability for antipsychotic drugs diverse pharmacological actions (1) ameliorate NMDAr antagonist-induced disruptions and (2)...
Abstract Traumatic brain injury (TBI) presents a major global health concern, characterized by variety of negative long term neurological outcomes. Current diagnostic tools lack the sensitivity to fully capture complex pathophysiology TBI and predict long-term consequences, underscoring need for robust methods biomarker detection. This study, conducted within multicenter Epilepsy Bioinformatics Study Antiepileptogenic Therapy (EpiBioS4Rx) framework, used standardized lateral fluid-percussion...
NMDAr antagonists induce disturbances to gamma frequency oscillations, including increasing ongoing activity and reducing evoked oscillations. We sought investigate the role parvalbumin (PV+) neurons CaMKIIα+ pyramidal cells in antagonist-induced oscillatory relate these common behavioural consequences of drugs by selectively deleting obligatory GluN1 subunit from mice. Adult mice (total n = 99) with deleted PV interneurons (PV:GluN1 KO) or (CaMKIIα:GluN1 KO), WT littermates, were used....
Abstract Objective Many people with epilepsy experience comorbid anxiety and depression, antidepressants remain a primary treatment for this. Emerging evidence suggests that these agents may modulate epileptogenesis to influence disease severity. Here, we assessed how the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine impacts epileptogenic, behavioral, pathological sequelae following status epilepticus. Methods Male Wistar rats received kainic acid induce epilepticus...
Schizophrenia is a complex psychiatric disorder with heterogeneous aetiology involving genetic and environmental factors. Deficiencies in both brain-derived neurotrophic factor (BDNF) NMDA receptor function have been implicated the may play causal synergistic roles. Perturbations regulation of electrophysiological signals, including high-frequency (γ: 30-80 Hz β: 20-30 Hz) neuronal oscillations, are also associated disorder. This study investigated influence BDNF deficiency hypofunction on...
Background: Abnormalities in neural oscillations that occur the gamma frequency range (30–80 Hz) may underlie cognitive deficits schizophrenia. Both impairments and oscillatory disturbances can be induced healthy people rodents by administration of N-methyl-D-aspartate receptor (NMDAr) antagonists. Aims: We studied relationships between impairment abnormalities following NMDAr antagonism, attempted to reverse with metabotropic glutamate type 2/3 (mGluR ) agonist LY379268. Methods: C57/Bl6...
Project 1 of the Preclinical Multicenter Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) consortium aims to identify preclinical biomarkers antiepileptogenic therapies following traumatic brain injury (TBI). The international participating centers in Finland, Australia, and United States have made a concerted effort ensure protocol harmonization. Here, we evaluate success harmonization process by assessing timing, coverage, performance between study sites.
Post-traumatic epilepsy (PTE) occurs in some patients following moderate/severe traumatic brain injury (TBI). While there are no approved therapies to prevent epileptogenesis, levetiracetam (LEV) is commonly given for seizure prophylaxis due its good safety profile. This led us study LEV as part of the Epilepsy Bioinformatics Study Antiepileptogenic Therapy (EpiBioS4Rx) Project. The objective this work characterize pharmacokinetics (PK) and uptake naïve control rats lateral fluid percussion...
Abstract Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and ketamine cause psychosis‐like symptoms in healthy humans, exacerbate schizophrenia people with the disorder, disrupt a range of schizophrenia‐relevant behaviors rodents, including hyperlocomotion. This is negated mice lacking GluN2D subunit NMDAR, suggesting mediates hyperlocomotor effects these drugs. However, role mediating other NMDAR antagonist‐induced behavioral disturbances, both sexes, unclear....
This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model posttraumatic (PTE) across three sites.
The 5xFAD mouse model of Alzheimer disease (AD) recapitulates amyloid-beta (Aβ) deposition and pronounced seizure susceptibility observed in patients with AD. Forty-hertz audiovisual stimulation is a noninvasive technique that entrains gamma neural oscillations can reduce Aβ pathology modulate glial expression AD models. We hypothesized 40-Hz sensory would improve mice this be associated reduction plaques modulation phenotypes.
Schizophrenia is a complex neuropsychiatric disorder characterized by psychoses, socioaffective disturbances, and cognitive deficits. The phosphodiesterase enzyme phospholipase C-β1 has been reported to be reduced in postmortem tissue of schizophrenia patients. Dysregulation neuronal oscillations, particularly those the higher frequency range such as beta (12–30 Hz) gamma (30–80 Hz), are also associated with this disorder. We investigated influence gene deletion on cortical oscillatory...