A5046538575- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Selenium in Biological Systems
- Neural dynamics and brain function
- Nanoparticles: synthesis and applications
- Metabolomics and Mass Spectrometry Studies
- Cassava research and cyanide
- Genomics and Chromatin Dynamics
- Food Security and Health in Diverse Populations
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Pediatric health and respiratory diseases
- Bioinformatics and Genomic Networks
- Electrokinetic Soil Remediation Techniques
- Amino Acid Enzymes and Metabolism
- Neurological Disorders and Treatments
- Chromosomal and Genetic Variations
- Food Waste Reduction and Sustainability
- Tryptophan and brain disorders
- Environmental remediation with nanomaterials
- Immunodeficiency and Autoimmune Disorders
- Biochemical effects in animals
The University of Melbourne
2021-2024
The Royal Melbourne Hospital
2021-2024
Yerevan State University
2024
Monash University
2022-2024
Sechenov University
2021
California Institute of Technology
2019
Penn State Milton S. Hershey Medical Center
2017
Agriculture productivity is severely hampered by salinity stress in many parts of the world, including Ararat Plain Armenia. The need for food security growing worldwide, and new strategies are essential to meet this challenge. In context Plain, paper examines potential utility promising role biogenic nanoparticles (NPs) biochar reducing stress, boosting crop resilience, guaranteeing sustainable production. This involves mechanisms underlying as well properties synthesis biochar, their...
How do neurons encode long-term memories? Bilateral imaging of neuronal activity in the mouse hippocampus reveals that, from one day to next, ~40% change their responsiveness cues, but thereafter only 1% cells per day. Despite these changes, responses are resilient a lack exposure previously completed task or lesions. Unlike individual neurons, which after few days, groups with inter- and intrahemispheric synchronous show stable for several weeks. The likelihood that neuron maintains its...
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed evaluate for disease modifying effects sodium selenate treatment in chronically epileptic rat post-status epilepticus (SE) model drug-resistant TLE. Wistar rats underwent kainic acid-induced SE or sham. Ten-weeks post-SE, animals received selenate, levetiracetam, vehicle subcutaneousinfusion...
Absence epilepsy syndromes are part of the genetic generalized epilepsies, pathogenesis which remains poorly understood, although a polygenic architecture is presumed. Current focus on single molecule or gene identification to elucidate epileptogenic drivers unable fully capture complex dysfunctional interactions occurring at genetic/proteomic/metabolomic level. Here, we employ multi-omic, network-based approach characterize molecular signature associated with absence epilepsy-like phenotype...
Linker DNA conformational variability has been proposed to direct nucleosome array folding into more or less compact chromatin fibers but experimental evidence for such models are lacking. Here, we tested this hypothesis by designing arrays with A-tracts at specific locations in the linkers induce inward (AT-IN) and outward (AT-OUT) bending of linker DNA. Using electron microscopy analytical centrifugation techniques, observed spontaneous AT-IN highly structures, comparable those induced...
Background: There is increased prevalence of epilepsy in patients with Alzheimer's disease (AD). Although shared pathological and clinical features have been identified, the underlying pathophysiology cause-effect relationships are poorly understood. We aimed to identify commonly dysregulated groups genes between these two disorders. Methods: Using publicly available transcriptomic data from hippocampal tissue temporal lobe (TLE), late onset AD non-AD controls, we constructed gene...
Individuals with Alzheimer's disease (AD) have a heightened risk of epilepsy. However, the underlying mechanisms are not well-understood.
Abstract Memories can persist for decades but how they are stably encoded in individual and groups of neurons is not known. To investigate a familiar environment CA1 over time we implanted bilateral microendoscopes transgenic mice to image the activity pyramidal hippocampus weeks. Most (90 %) active every day, however, response specific cues changes across days. Approximately 40 % place cells lose fields between two days; on timescales longer than days neuronal pattern at rate 1 each...
The 5xFAD mouse model of Alzheimer disease (AD) recapitulates amyloid-beta (Aβ) deposition and pronounced seizure susceptibility observed in patients with AD. Forty-hertz audiovisual stimulation is a noninvasive technique that entrains gamma neural oscillations can reduce Aβ pathology modulate glial expression AD models. We hypothesized 40-Hz sensory would improve mice this be associated reduction plaques modulation phenotypes.
Abstract There are no pharmacological disease-modifying treatments that can mitigate the seizures and comorbidities associated with established chronic temporal lobe epilepsy (TLE). This study evaluated effect of sodium selenate in post-status epilepticus (SE) rat model drug resistant TLE. Wistar rats underwent kainic acid-induced SE or sham. Ten-weeks post-SE, were randomly assigned to receive either selenate, levetiracetam, vehicle continuously for 4 weeks. To evaluate effects treatments,...
The article discusses the features of emergence and development so-called opportunistic infections that occur in children with weakened immunity.
 Such are often caused by non-tuberculosis mycobacteria, fungi, herpesviruses, such can also develop who treated immunobiological drugs. Since these serious rapidly developing diseases, diagnosis should be made at earliest stages disease based on clinical phenomena described literature anamnesis data indicating presence infections. earlier an...