A5063891394- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Drug Transport and Resistance Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical studies and practices
- Traumatic Brain Injury and Neurovascular Disturbances
- Folate and B Vitamins Research
- Diabetes Management and Research
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Neonatal and fetal brain pathology
- Child Abuse and Related Trauma
- Sulfur Compounds in Biology
- Pain Mechanisms and Treatments
- Child Abuse and Trauma
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury Research
- Metabolism and Genetic Disorders
- Stroke Rehabilitation and Recovery
- Mitochondrial Function and Pathology
- Diabetes Treatment and Management
- Adenosine and Purinergic Signaling
University of Minnesota
2014-2024
Twin Cities Orthopedics
2023-2024
University of Michigan
2021
Medical University of South Carolina
2019-2021
Massachusetts General Hospital
2021
The Ohio State University Wexner Medical Center
2021
Mayo Clinic
2021
Amgen (United States)
2021
University of California, Davis
2021
HealthPartners
2019
Thirty-one patients with atypical non-cardiac chest pain which had persisted despite negative medical investigation were treated in a controlled trial of cognitive-behavioural therapy. The average duration was 4.7 years. Patients randomized to either immediate treatment or as control assessment only. Treatment involved teaching how anticipate and symptoms, modification inappropriate health beliefs. number sessions given 7.2. There significant reductions pain. limitations disruption daily...
Objective This study aimed to determine if the antioxidant N-acetylcysteine (NAC) is able alter peripheral and central redox capabilities in patients with Parkinson disease (PD) or Gaucher (GD). Methods The included nondemented adult subjects: 3 PD, GD, healthy controls. Baseline brain glutathione (GSH) concentrations were measured using 7-T magnetic resonance spectroscopy (MRS). blood reduced-to-oxidized GSH ratios determined for each subject. Brain then during at specified time points...
Abstract Parkinson's disease (PD) is associated with oxidative stress and decreased nigral glutathione (GSH), suggesting that therapies boost GSH may have a disease‐modifying effect. Intravenous administration of high dose N‐acetylcysteine (NAC), well‐known antioxidant precursor, increases blood brain in individuals PD Gaucher healthy controls. To characterize the pharmacokinetics repeated oral doses NAC their effect on measures, we conducted 4‐week open‐label prospective study (n = 5)...
Abstract Objective This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment status epilepticus (SE) and test the association doses with response second‐line agents in patients enrolled Established Status Epilepticus Treatment Trial (ESETT). Methods Patients refractory an adequate dose benzodiazepines for SE were ESETT. Choice benzodiazepine, given prior administration agent, route administration, setting, patient weight characterized. These compared...
We examined the effect of a single exercise session on protein and mRNA expression monocarboxylate transporters MCT1 MCT4 in rat soleus (SOL), red (RG) white gastrocnemius (WG) muscles. Muscle samples were obtained at rest before 2 h treadmill (21 m min −1 , 15% grade) immediately after exercise, as well 5, 10 24 exercise. During bout, proteins RG (+60%) WG (+56%) increased ( P < 0.05). was further thereafter, with peak increments occurring (+157%), (+193%) SOL (+179%) Twenty‐four hours...
Summary A subgroup of patients with drug‐resistant epilepsy have seizure clusters, which are a part the continuum emergencies that includes prolonged episodes and status epilepticus. When patient or caregiver can identify beginning cluster, condition is amenable to certain treatments, an approach known as rescue therapy. Intravenous drug administration offers fastest onset action, but this route usually not option because most clusters occur outside medical facility. Alternate routes been...
The effect of progesterone and estrogen treatment on the expression function P-glycoprotein (P-gp) was evaluated in JAR cells a P-gp overexpressing cell line, NCI-ADR-RES. Western blot analysis real-time Q-PCR were used to evaluate protein MDR1 mRNA respectively following incubation with (P4) and/or beta-estradiol (E2). Cellular uptake studies substrates, saquinavir paclitaxel, performed function. Treatment either E2 or P4 resulted significant increase levels NCI-ADR-RES at concentrations...
Abstract Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. Preliminary data have shown lower brain adenosine triphosphate (ATP) levels disease versus age‐matched healthy controls. Ursodeoxycholic acid (UDCA) may improve impaired mitochondrial function. Our objective was to evaluate UDCA tolerability, pharmacokinetics, and its effect on bioenergetics individuals with An open‐label, prospective, multiple‐ascending‐dose study oral 5 completed. A blood safety...
Sodium selenate (SS) activates protein phosphatase 2 (PP2A) and reduces phosphorylated tau (pTAU) late post-traumatic seizures after lateral fluid percussion injury (LFPI). In EpiBioS4Rx Project 2, a multi-center international study for targets, biomarkers, treatments, we tested the target relevance modification by SS of pTAU forms PP2A in LFPI model, at two sites: Einstein Melbourne. Experiment 1, adult male rats were assigned to sham (both sites) naïve controls (Einstein). Motor function...
Abstract Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain (TBI) to identify early plasma biomarkers predicting injury, post‐traumatic seizures or neuromotor functional recovery (neuroscores), considering effect levetiracetam, which is commonly given after severe TBI. Methods Adult male Sprague–Dawley rats underwent left parietal LFPI, received levetiracetam (200 mg/kg bolus, 200 mg/kg/day subcutaneously for 7 days [7d]) vehicle...
Current treatment of human status epilepticus (SE) relies on drugs developed for chronic epilepsy. Many potent compounds have been discovered in animal models SE. But they may never be useful epilepsy and thus not available use. Naturally occurring canine SE become a translational platform evaluating these eventual use trials. A pilot study levetiracetam demonstrated 56% response rate compared to 10% placebo. Based results we obtained an NIH R-21 further evaluate as developing new approaches treating
Our objective was to characterize baclofen pharmacokinetics and safety given orally intravenously. Twelve healthy subjects were enrolled in a randomized, open-label, crossover study received single doses of baclofen: 3 or 5 mg intravenously 10 taken with 48-hour washout. Blood samples for analysis collected pre-dose at regular intervals up 24 hours post-dose. Clinical response assessed by sedation scores, ataxia, nystagmus. Mean absolute bioavailability oral 74%. Dose-adjusted areas under...
Abnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor the progression of neurodegenerative diseases such as Parkinson’s disease (PD). Recent advancements in field magnetic resonance (MR) based metabolic imaging provide state-of-the-art technologies for non-invasively probing cerebral under various brain conditions. In this proof-of-principle clinical study, we employed quantitative 31P MR spectroscopy (MRS) techniques determine...
Abstract Subdural haemorrhage (SDH) in infants arises most commonly from non‐accidental head injury (NAHI) shaking. Patients present with a varied severity of illness and variety symptoms signs. Data on long‐term outcome the survivors are not widely reported. The aim this paper is to describe physical educational outcomes children <2 years diagnosed formulate guidelines follow‐up. 65 subdural CT/MRI/postmortem were extracted hospital community notes education reports. Kings Outcome Scale...
There are a limited number of marketed intravenous antiepileptic drugs (AEDs) available to treat status epilepticus (SE). All were first developed for chronic therapy epilepsy, not specifically SE. Epilepsy and canine SE (CSE) occur naturally in dogs, with prevalence, presentation, percentage refractory cases similar human epilepsy. The objective this study was determine if CSE treated fosphenytoin (FOS) results responder rate as people.A randomized clinical trial performed dogs CSE. Dogs...
Abstract Background Abrupt discontinuation of baclofen can result in a potentially severe withdrawal syndrome. The current treatment for is inadequate, resulting critical need to develop an alternative method prevent or treat this Objective To evaluate the safety profile and pharmacokinetics oral (PO) investigational intravenous (IV) formulations at clinically relevant doses. Design Randomized, open‐label, dose‐escalation, crossover study. Setting Contract Research Organization (CRO)....