A5087367713- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Thermoregulation and physiological responses
- Glioma Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Thermal Regulation in Medicine
- Mitochondrial Function and Pathology
- Climate Change and Health Impacts
- Neuroscience and Neural Engineering
- Traumatic Brain Injury Research
Nathan Kline Institute for Psychiatric Research
2021-2025
New York State Office of Mental Health
2021-2025
New York University
2021-2025
Albert Einstein College of Medicine
2018-2023
NYU Langone Health
2021-2023
University of Ioannina
2017-2021
Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this problem, we slightly modified previous methods and show are common frequent in both male female mice. We employed continuous wideband video-EEG monitoring from 4 recording sites best demonstrate the seizures. found many more convulsive than most studies have reported. Mortality was low. Analysis at 2–4 10–12 wks...
Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's disease (AD) and preclinical models. The brain regions where IIS largest not known but important because such data would suggest sites that contribute to generation. Because hippocampus cortex exhibit altered excitability AD models, we asked which areas dominate the during along cortical-CA1-dentate gyrus (DG) dorso-ventral axis. medial septal (MS) cholinergic neurons overactive when typically occur,...
To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) thus are not unique to epilepsy.
Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach reduces seizure frequency in mouse model of TLE. However, whether seizures could be stopped timing inhibition just as begins unclear. Furthermore, would reduce the cortical motor manifestations not clear. Finally, interictal EEG abnormalities TLE...
Sodium selenate (SS) activates protein phosphatase 2 (PP2A) and reduces phosphorylated tau (pTAU) late post-traumatic seizures after lateral fluid percussion injury (LFPI). In EpiBioS4Rx Project 2, a multi-center international study for targets, biomarkers, treatments, we tested the target relevance modification by SS of pTAU forms PP2A in LFPI model, at two sites: Einstein Melbourne. Experiment 1, adult male rats were assigned to sham (both sites) naïve controls (Einstein). Motor function...
A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant seizures associated with mesial sclerosis, in which there is extensive cell loss the hippocampal CA1 and CA3 subfields, a relative sparing dentate gyrus granule cells CA2 pyramidal neurons (PNs). role for seizure generation was suggested based on findings reduction synaptic inhibition (Williamson Spencer, 1994) presence interictal-like spike activity resected tissue from TLE (Wittner et al., 2009). We...
Post-traumatic epilepsy (PTE) occurs in some patients following moderate/severe traumatic brain injury (TBI). While there are no approved therapies to prevent epileptogenesis, levetiracetam (LEV) is commonly given for seizure prophylaxis due its good safety profile. This led us study LEV as part of the Epilepsy Bioinformatics Study Antiepileptogenic Therapy (EpiBioS4Rx) Project. The objective this work characterize pharmacokinetics (PK) and uptake naïve control rats lateral fluid percussion...
Epilepsy is a chronic neurological disorder characterized by the rapid occurrence of epileptic seizures affecting approximately 70 million people worldwide. The quality life with epilepsy (PWE) challenged series comorbidities that might include neurologic and neuropsychiatric disorders (cognitive decline, depression, anxiety, schizophrenia, autism) as well metabolic, cardiovascular respiratory diseases. Neurobehavioral other share reciprocal complex relationship epileptogenesis ictogenesis...
ABSTRACT Objective To test the hypothesis that high frequency oscillations (HFOs) between 250 and 500Hz occur in mouse models of Alzheimer’s disease (AD) thus are not unique to epilepsy. Methods Experiments were conducted three AD: Tg2576 mice simulate a form familial AD, presenilin 2 knock-out (PS2KO) mice, Ts65Dn model Down’s syndrome. We recorded HFOs using wideband (0.1-500Hz, 2kHz) intra-hippocampal cortical surface EEG at 1month until 24months-old during wakefulness, slow wave sleep...
Abstract Background Clinical and preclinical evidence suggest that abnormal electrical activity strongly impacts outcomes in Alzheimer's disease (AD). Indeed, AD patients with interictal spikes (IIS) show faster cognitive decline than those without IIS. Furthermore, seizures have been suggested to accelerate progression. Here we asked whether high‐frequency oscillations (HFOs), which for the last 20 years considered a promising electrophysiological biomarker epilepsy, also occur models....
ABSTRACT Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this problem, we slightly modified previous methods and show are common frequent in both male female mice. We employed continuous wideband video-EEG monitoring from 4 recording sites best demonstrate the seizures. found many more convulsive than most studies have reported. Mortality was low. Analysis at 2-4 10-12 wks...
Interictal spikes (IIS) occur in 3 mouse lines with Alzheimer's disease featuresIIS all were most frequent during rapid eye movement (REM) sleepThe dentate gyrus showed larger IIS and earlier current sources vs. CA1 or cortexChemogenetic silencing of medial septum (MS) cholinergic neurons reduced REMMS did not change REM latency, duration, number bouts theta power.Interictal are a common type abnormal electrical activity (AD) preclinical models. The brain regions where largest known but...
#### Objective To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) thus are not unique to epilepsy. Methods Experiments were conducted three AD: Tg2576 mice simulate a form familial AD, presenilin 2 knock-out (PS2KO) mice, Ts65Dn model Down's syndrome. We recorded HFOs using wideband (0.1–500 Hz, kHz) intra-hippocampal cortical surface electroencephalography (EEG) at 1 month until 24 months age during...
ABSTRACT Interictal spikes (IIS) and seizures are well-documented in Alzheimer’s disease (AD). IIS typically outnumber seizures, supporting their role as a prominent EEG biomarker AD. In preclinical models, we showed that high frequency oscillations (HFOs>250Hz) also occur, but it is currently unknown how HFOs compare to IIS. Therefore, asked whether the incidence of differed if they differentially affected by behavioral state. We used three mouse lines simulate aspects AD: Tg2576,...
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative illness characterized by progressive accumulation of amyloid beta (Aβ) and neurofibrillary tangles, with cognitive impairment altered neural activity. Hyperexcitability in the early stages AD contribute to Aβ impairment, aggravating progression AD. However, hyperexcitability origin not clear. This study aimed test whether mossy cells (MCs), an excitatory cell hippocampal dentate gyrus, show increased excitability at network...
ABSTRACT Convulsive status epilepticus (SE) in immature life is often associated with lasting neurobiological changes. We provoked SE by pentylenetetrazole postnatal day 20 rat pups and examined communication modalities between the temporal hippocampus medial entorhinal cortex (mEC) vitro . After a minimum of 40 days post-SE, we prepared combined hippocampal - slices from conditioned naïve (N) adult rats recorded 4-aminopyridine-induced spontaneous epileptiform interictal-like discharges...