A5089845134- Hydrogels: synthesis, properties, applications
- Drug Solubulity and Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Drug Delivery Systems
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Advanced Sensor and Energy Harvesting Materials
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Protein purification and stability
- Epilepsy research and treatment
- Analytical Chemistry and Chromatography
- Nonlinear Dynamics and Pattern Formation
- Analytical Chemistry and Sensors
- Polymer Surface Interaction Studies
- Rheology and Fluid Dynamics Studies
- Block Copolymer Self-Assembly
- Electrowetting and Microfluidic Technologies
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Diabetes Management and Research
University of Minnesota
2016-2025
Mayo Clinic
2023
University of Minnesota System
2003-2022
University of O'Higgins
2022
HealthPartners
2019
Minneapolis Institute of Arts
2019
Pharmac
2000-2017
Montana State University
2006
Centro Nacional de Microelectrónica
2004
Twin Cities Orthopedics
2004
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTpH-dependent equilibrium swelling properties of hydrophobic polyelectrolyte copolymer gelsRonald A. Siegel and Bruce FirestoneCite this: Macromolecules 1988, 21, 11, 3254–3259Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ma00189a021https://doi.org/10.1021/ma00189a021research-articleACS PublicationsRequest reuse permissionsArticle...
The exploitation of biological macromolecules, such as nucleic acids, for the fabrication advanced materials is a promising area research. Although greater variety structural and functional uses can be envisioned protein-based materials, systematic approaches their construction have yet to emerge. Consistent with theoretical models polymer macrocyclization, we demonstrated that, in presence dimeric methotrexate (bisMTX), wild-type Escherichia coli dihydrofolate reductase (DHFR) molecules...
We describe a PCR-based method for the generation of plasmid multimers that can be directly transformed into Bacillus subtilis with very high efficiency. This technique is particularly useful large libraries randomly mutagenized genes, which are required optimization enzymes by directed evolution. subjected gene coding protease subtilisin to six consecutive rounds PCR at three different levels mutagenicity. The resulting 18 populations were cloned using our multimerization protocol, and...
This paper reports on the fabrication and test of a hydrogel-actuated microvalve that responds to changes in concentration specific chemical species an external liquid environment. The consists thin hydrogel, sandwiched between stiff porous membrane flexible silicone rubber diaphragm. Swelling deswelling which results from diffusion through is accompanied by deflection diaphragm hence closure opening valve intake orifice. A phenylboronic-acid-based hydrogel was used construct smart glucose...
Abstract The aqueous kinetic swelling properties of a class cross‐linked hydrophobic polyamine copolymer gels based on n ‐alkyl esters methacrylic acid ( AMA) and N,N ‐dimethylaminoethyl methacrylate (DMA) have been studied as function solution ionic composition (pH, strength, buffer content), gel composition, temperature. Water uptake in these are driven by ionization the DMA amine groups, which overcomes tendency to exclude water unionized state. Sorption kinetics initially glassy disks...
In this paper, we report on the design and characterization of a new hydrogel-based implantable wireless glucose sensor. The basic device structure is passive [inductor/capacitor (LC)] micromachined resonator coupled to stimuli-sensitive hydrogel, which confined between stiff nanoporous membrane thin glass diaphragm. As molecules pass through membrane, hydrogel swells deflects flexible diaphragm, movable plate variable capacitor in totally integrated LC resonator. corresponding change...
Abstract Pressure‐sensitive adhesives (PSAs) are finding increasing applications in various areas of industry and medicine. PSAs a special class viscoelastic polymers that form strong adhesive joints with substrates varying chemical nature under application light external bonding pressures (1–10 Pa) over short periods time (1–5 s). To be PSA, polymer should possess both high fluidity applied pressure, to good contact, cohesive strength elasticity, which necessary for resistance debonding...
Summary A subgroup of patients with drug‐resistant epilepsy have seizure clusters, which are a part the continuum emergencies that includes prolonged episodes and status epilepticus. When patient or caregiver can identify beginning cluster, condition is amenable to certain treatments, an approach known as rescue therapy. Intravenous drug administration offers fastest onset action, but this route usually not option because most clusters occur outside medical facility. Alternate routes been...