A5010223119- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Gastrointestinal motility and disorders
- Stress Responses and Cortisol
- Microscopic Colitis
- Mental Health and Psychiatry
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Traumatic Brain Injury Research
- Musculoskeletal pain and rehabilitation
- Music Therapy and Health
- Neuroendocrine regulation and behavior
- Health, psychology, and well-being
- Stoma care and complications
- Noise Effects and Management
- Bipolar Disorder and Treatment
- Memory and Neural Mechanisms
- Complementary and Alternative Medicine Studies
- Anesthesia and Neurotoxicity Research
- Air Quality and Health Impacts
- Ion channel regulation and function
- Psychosomatic Disorders and Their Treatments
- Eosinophilic Esophagitis
- Electromagnetic Fields and Biological Effects
The University of Melbourne
2014-2024
The Royal Melbourne Hospital
2010-2024
St Vincent's Hospital
2012-2021
Royal College of Physicians
2019
St Vincent's Health
2008-2016
St. Vincent's Birmingham
2006-2016
Saint Vincent's Catholic Medical Center
2016
Swinburne University of Technology
2013
Imperial College London
2013
Murdoch Children's Research Institute
2010
The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr) antagonists, induce cognitive impairment aggravate schizophrenia symptoms. In conscious rats, they produce an abnormal behavior associated with a peculiar brain state characterized by increased synchronization in ongoing gamma (30-80 Hz) oscillations the frontoparietal (sensorimotor) electrocorticogram (ECoG). This study investigated whether NMDAr antagonists-induced aberrant are correlated locomotion dependent...
To test the hypothesis that neuropsychiatric symptomatology is predictive of success seizure control in patients newly treated with antiepileptic drugs (AEDs), and this value adds to provided by other clinical, imaging, genomic factors a multivariate model.One hundred seventy epilepsy completed A-B Neuropsychological Assessment Scale (ABNAS) before commencing AED therapy were prospectively followed up for 12 months. Patients classified as nonresponsive if they had at least 1 not explained...
Summary Purpose: Early life stress has enduring behavioral and neuroendocrine effects, particularly in hippocampus amygdala. This may be relevant to mesial temporal lobe epilepsy (MTLE) that arises from these structures. In rats, we tested the hypothesis early postnatal stress, form of maternal separation (MS), creates vulnerability limbic epileptogenesis adult life. Methods: On days 2–14, exposed male female nonepileptic rats either MS for 180 min/day, or handling (EH) brief (15 min/day)....
Mood disturbances, including depression and anxiety disorders, are common disabling long-term sequelae of traumatic brain injury (TBI). These psychiatric conditions have generally been considered psychosocial consequences the trauma, but neurobiological alterations causes also implicated. Using a rat model TBI (lateral fluid-percussion injury), this longitudinal study seeks to assess depression-like behaviors following experimental TBI. Male Wistar rats (n = 20) received severe...
A single non-anaesthetic dose of ketamine, a non-competitive NMDA receptor (NMDAR) antagonist with hallucinogenic properties, induces cognitive impairment and psychosis, aggravates schizophrenia symptoms in patients. In conscious rats an equivalent ketamine key features animal models acute including hyperlocomotor activity, deficits prepulse inhibition gating auditory evoked potentials, concomitantly increases the power ongoing spontaneously occurring gamma (30-80 Hz) oscillations neocortex....
Background Exposure to early postnatal stress is known hasten the progression of kindling epileptogenesis in adult rats. Despite significance this for understanding mesial temporal lobe epilepsy (MTLE) and its associated psychopathology, research findings regarding underlying mechanisms are sparse. Of several possibilities, one important candidate mechanism life 'programming' hypothalamic-pituitary-adrenal (HPA) axis by stress. Elevated corticosterone (CORT) turn has consequences...
Abstract In a population‐based case‐control study of 416 incident gliomas in adults carried out Melbourne, Australia, between 1987 and 1991, 409 age‐sex‐matched pairs (243 male 166 female) had adequate data available to examine associations the dietary intake N ‐nitroso compounds, precursors, other nutrients including inhibitors, risk glioma. Dietary intakes were based on reported frequency consumption 59 food items. Increased odds ratio (OR) observed males who consumed high levels bacon,...
Summary: Purpose: Depression is common in temporal lobe epilepsy (TLE) and after lobectomy, its etiology obscure. In nonepileptic depression (including associated with other neurologic disorders), a consistent PET imaging finding frontal hypometabolism. Many TLE patients have hypometabolism involving regions. Thus data available from routine clinical assessments an surgery unit, we tested the hypothesis that pattern of hypometabolism, particularly lobe, may be seen surgery. Methods: We...
Previous work has identified elevated prevalence rates for psychiatric disorders in individuals with medically refractory focal epilepsy, particularly temporal lobe epilepsy. Many studies were undertaken before the advent of video electroencephalogram monitoring (VEM) and magnetic resonance imaging (MRI).To investigate which characteristics epilepsy syndromes are associated presence depression or psychosis.Three hundred nineteen admitted VEM seen over an 11-year period. The lifetime history...
A population-based case-control study of 416 histologically diagnosed, incident gliomas in adults was carried out Melbourne, Australia, to determine whether past medical, family or reproductive histories are risk factors for developing glioma. total 422 controls were selected from the Australian electoral roll and matched cases age, sex post code residence. An increased glioma observed among first-born individuals OR (95% CI) 2.0 (1.4–29). It is possible that this effect due residual...
BACKGROUND: Occupational hygiene panels are increasingly being used to rate retrospective occupational exposures chemicals in community-based studies. This study aimed assess the validity, reliability and feasibility of using such an expert panel a brain tumour case-control study. METHODS: A five experts was recruited exposure 21 for 298 job descriptions investigate level agreement. Validity assessed by comparing ratings 49 jobs with objective quantitative data which existed these jobs....
PURPOSE: The aims of this research were to explore associations among elective versus emergency surgery, type ostomy (permanent vs temporary), illness perceptions and coping style, anxiety, depression, health-related quality life in persons with Crohn's disease. A further aim was determine the extent current past use psychological care psychotropic medications. SUBJECTS AND SETTING: sample comprised 31 (17 men 14 women; mean age 45 years) disease an from 2 large teaching hospitals Melbourne,...
The possible association between prior infection with the protozoan Toxoplasma gondii and development of brain tumours was investigated as part two Australian population-based case-control studies adult tumours. One study, based in Adelaide, South Australia, collected blood from 73 subjects glioma, 53 meningioma 348 controls. other Melbourne, Victoria, 44 glioma 67 All had been verified histologically. IgG antibodies to T. were measured using Enzyme Linked Immunosorbent Assay (ELISA)...